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| 1 | Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium显示文摘Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 (Bmp2) in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 (P0), followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2 gene is removed from Sp7+ (Osterix+) cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC (Nfic), periostin and α-SMA+ cells. Third, there is a failure to produce vascular endothelial growth factor A (VEGF-A) in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOSp7-Cre-EGFP . Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOSp7-Cre-EGFP . These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation. | Audrey Rakian Wu-Chen Yang Jelica Gluhak-Heinrich Yong Cui Marie A Harris Demitri Villarreal Jerry Q Feng Mary MacDougall Stephen E Harris | 2013 | International Journal of Oral Science2013，5，2： | 14 |
| 2 | Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate显示文摘 | Jiezhao Zheng Zhujun Li Rui Tian Youming Lu Xiangyu Guo Yong-hui Jiang Xiao-Jiang Li Yong Q Zhang | 2017 | Cell Research2017，27，10： | 11 |
| 3 | The genetic heterozygosity and fitness of tetraploid embryos and embryonic stem cells are crucial parameters influencing survival of mice derived from embryonic stem cells by tetraploid embryo aggregation显示文摘 | Li X Wei W Yong J Jia Q Yu Y Di K | 2006 | 中国生物学文摘2006，20，7： | 3 |
| 4 | Simulating the worn surface in a wearprocess 显示文摘 | Yong Ao Q Jane Wang Penny Chen | 2002 | Wear2002，252，12： | 1 |
| 5 | An analytical model for the kinetics of strain-induced precipitation in titanium micro- alloyed steels显示文摘 | WANG Z Q YONG Q L SUN X J | 2012 | ISIJ Int2012，52，： | 1 |
| 6 | Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-1 显示文摘 | Kanzaki M Yong Q Z Mashima H | 1999 | Nature Cell Biology1999，1，3： | 1 |
| 7 | Three-stage hydrolysis to enhance enzymatic saccharification of steam-exploded corn stover显示文摘 | YANG J ZHANG X P YONG Q | 2010 | Bioresour Teeh2010，101，13： | 1 |
| 8 | Mucinous tubular and spin-dle cell carcinoma and solid variant papillary renal cell carci-noma: a clinicopathologic comparative analysis of four caseswith similar molecular genetics datum 显示文摘 | Zhang Y Yong X Wu Q | 2014 | Diagn Pathol?2014，9，： | 1 |
| 9 | Reversible underwater Iosslcss oil droplet transportation显示文摘 | YONG J YANG Q CHEN F | 2015 | Advanced Materials In- terfhces2015，2，14： | 1 |
| 10 | Three-stage enzymatic hydrolysis of steam-exploded corn stover at high substrate concentration 显示文摘 | YANG J ZHANG X P YONG Q | 2011 | Bioresour Tech2011，102，7： | 1 |
| 11 | On selection of repeated unit cell model and application of unified periodic boundary conditions in micro - mechanical analysis of composites 显示文摘 | Xia Z H Zhou C W Yong Q L | 2006 | International Journal of Solid & Structure2006，43，2： | 1 |
| 12 | Development of a Monoclonal Antibody-Based ELISA to Detect Escherichia coli O157 : H7 显示文摘 | Feng M Yong Q Wang W | 2012 | Food and Agricultural Immunology2012，33，1： | 1 |
| 13 | Enviroment-sensitive hydrogels for drugdeli very 显示文摘 | YONG Q KINAM P | 2001 | Adv Drug Delivery Rev2001，53，11： | 1 |
| 14 | Intralesional injection of adiposederivedstem cells reduces hypertrophic scarring in a rabbit earmodel显示文摘 | Zhang Q Liu LN Yong Q | 2015 | Stem Cell Res Ther2015，6，： | 1 |
| 15 | Instantaneous torque estimation in sensorless direct-torque-controlled brushless DC motors 显示文摘 | Liu Yong Zhu Z Q Howe D | 2006 | IEEE Transactions on Industry Applications2006，42，5： | 1 |
| 16 | Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs显示文摘 | LIU Y L JING J H YONG Q H | 2008 | British Journal of Nutrition2008，100，： | 1 |
| 17 | Direct torque control of brushless DC drives with reduced torque ripple显示文摘 | LIU Yong ZHU Z Q HOWE D | 2005 | IEEE Trans on Ind Appl2005，41，2： | 1 |
| 18 | Delay-dependent H control of linear discrete-time systems with an interval-like time-varying delay显示文摘 | Yong H E WU M HAN Q L | 2008 | Int J Syst Sci2008，39，4： | 1 |
| 19 | Analysis of Project Delivery Systems in Chinese Construction Industry with Data Envelopment Analysis(DEA)显示文摘 | YONG Q C HUANQING L WENXUE L | 2010 | Engineering Construction and Architechmal Management2010，17，6： | 1 |
| 20 | Mechanical properties and microstructural evolution of TiN coatings alloyed with A1 and Si显示文摘 | CHEN Li DU Yong WANG S Q WANG A J XU H H | 2009 | Materials Science and Engineering A2009，509，： | 1 |
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