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| 1 | ^11C-PIBPET和^18F-FDGPET显像诊断阿尔茨海默病与遗忘型轻度认知损害的临床价值显示文摘目的应用11C-PIB PET和18F-FDG PET显像研究阿尔茨海默病和遗忘型轻度认知损害患者β-淀粉样蛋白(Aβ)沉积与葡萄糖代谢之间的关系,联合载脂蛋白E(ApoE)基因型进一步探讨遗忘型轻度认知损害与阿尔茨海默病的相关性。方法利用PET显像对阿尔茨海默病(14例)、遗忘型轻度认知损害(10例)和正常对照者(5例)脑组织Aβ沉积和葡萄糖代谢变化进行分析,采用聚合酶链反应-限制性片段长度多态性方法对ApoE基因型进行分析。结果阿尔茨海默病组患者11C-PIB标准化摄取比值在下顶叶、颞叶外侧、额叶、后扣带回皮质和楔前叶、枕叶和纹状体均高于正常对照组(P<0.05);遗忘型轻度认知损害组患者脑组织11C-PIB结合水平呈双峰形。11C-PIB+aMCI亚组与阿尔茨海默病组、11C-PIB-aMCI亚组与正常对照组之间11C-PIB标准化摄取比值差异均无统计学意义(P>0.05)。18F-FDG PET显像显示,3/5例11C-PIB+aMCI亚组患者双侧顶叶、颞叶和楔前叶代谢减低,其中2例ApoEε4等位基因携带者随访期间进展至阿尔茨海默病;3/5例11C-PIB-aMCI亚组患者双侧额叶和前扣带回代谢减低。结论11C-PIB PET显像是筛查具有阿尔茨海默病病理特点的遗忘型轻度认知损害患者的有效工具。具有阿尔茨海默病病理特征的遗忘型轻度认知损害患者可伴有顶叶、颞叶外侧皮质和楔前叶代谢减低,其中ApoEε4等位基因携带者更易进展至阿尔茨海默病痴呆。 | Shi Zhihong Wang Ying Liu Shuai Liu Shuling Z hou Yuying Wang Jinhuan Cai Li Gao Shuo Ji Yong | 2014 | 中国现代神经疾病杂志2014，14，3： | 8 |
| 2 | Multilinear Singular and Fractional Integrals显示文摘In this paper, we treat a class of non-standard commutators with higher order remaindersin the Lipschitz spaces and give (L^p, L^q), (H^p, L^q) boundedness and the boundedness in the Triebel-Lizorkin spaces. Our results give simplified proofs of the recent works by Chen, and extend his result. | Yong DING Shan Zhen LU Kz YABUTA | 2006 | Acta Mathematica Sinica,English Series2006，22，2： | 8 |
| 3 | Free volume and water vapor permeability of dense segmented polyurethane membrane显示文摘 | Mondal S Hu J L Yong Z | 2006 | Journal of Membrane Science2006，280，： | 1 |
| 4 | The characteristics and stability of a dielectric elastomer spherical shell with a thick wall显示文摘 | He X Z Yong H D Zhou Y H | 2011 | Smart Material and Structures2011，20，05： | 1 |
| 5 | An efficient and user-frlendly method forthe synthesis of hexagonal-phaseNaYF4:Yb, Er/Tm nanocrystals with- controllable shape and upconversionfluorescence 显示文摘 | Zhengquan L Yong Z | 2008 | Nanotechnolo- gy2008，19，34： | 1 |
| 6 | An analytical model for the kinetics of strain-induced precipitation in titanium micro- alloyed steels显示文摘 | WANG Z Q YONG Q L SUN X J | 2012 | ISIJ Int2012，52，： | 1 |
| 7 | Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-1 显示文摘 | Kanzaki M Yong Q Z Mashima H | 1999 | Nature Cell Biology1999，1，3： | 1 |
| 8 | Hydroxyapatite chitin materals as potential tissue engineered bone substitutes显示文摘 | Ge Z Baguenard S Yong L | 2004 | Biomaterials2004，25，6： | 1 |
| 9 | Catalpol attenuates MPTF re- duced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neuro- trophic factor in striatum 显示文摘 | Xu G Xiong Z Yong Y | 2010 | Neuroscience2010，167，1： | 1 |
| 10 | DIVA:A Visualization System for Exploring Documents Databases for Technology Forecasting显示文摘 | S Morris C Yong Z Wu | 2002 | Computers & Industrial Engineering2002，43，4： | 1 |
| 11 | A sufficient condition for a planar graph to be class 1显示文摘 | WEI F W YONG Z C | 2007 | Theoretical Computer Sci2007，385，13： | 1 |
| 12 | 显示文摘 | Yong Z Mata V Rodrigues A E | 2002 | Separation and Purification Technology2002，26，： | 1 |
| 13 | Modeling the slag layer in solid fuel gasification and combustion-formulation and sensitivity analysis显示文摘 | Yong S Z Gazzino M Ghoniem A | 2012 | Fuel2012，92，1： | 1 |
| 14 | Oxy - fuel combustionof pulverized coal: Characterization,fundamentals stabilizationand CFD modeling显示文摘 | Chen L Yong S Z Ghoniem A F | 2012 | Progress in Energy and Combustion Sci-ence2012，38，2： | 1 |
| 15 | MicroRNA-1 downregu- lation by propranolol in a rat model of myocardial infarction : a new mechanism for ischaemic cardioprotection 显示文摘 | YAN J L YONG Z HONG L S | 2009 | Cardio- vasc Res2009，84，3： | 1 |
| 16 | Novel target type flowmeter based on fl differential fiber Bragg grating sensor 显示文摘 | Yong Z Kun C Jian Y | 2005 | Measurement2005，38，： | 1 |
| 17 | Oxy-fuel combustion of pulverized coal: characterization, fundamentals, stabilization and CFD modeling 显示文摘 | Chen L Yong S Z Ghoniem A F | 2012 | Progress in Energy and Combustion Science2012，38，2： | 1 |
| 18 | Contamination of persistent organic pollutant(POPs) and relevant management in China显示文摘 | TIE W YONG L HONG Z | 2005 | Environment International2005，31，6： | 1 |
| 19 | High-capacity hydrogen stor age in lithium and sodium amidoboranes显示文摘 | Xiong Z Yong C K Wu G | 2007 | Nature Materials2007，7，2： | 1 |
| 20 | Assessment of the NationalEco-Industrial Park Standard for Promoting IndustrialSymbiosis in China显示文摘 | Yong G Pan Z C-té R P | 2009 | Journal of Industrial Ecology2009，13，1： | 1 |
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