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| 1 | Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer显示文摘Myeloid-derived suppressor cells(MDSCs)are a heterogenic population of immature myeloid cells with immunosuppressive effects,which undergo massive expansion during tumor progression.These cells not only support immune escape directly but also promote tumor invasion via various non-immunological activities.Besides,this group of cells are proved to impair the efficiency of current antitumor strategies such as chemotherapy,radiotherapy,and immunotherapy.Therefore,MDSCs are considered as potential therapeutic targets for cancer therapy.Treatment strategies targeting MDSCs have shown promising outcomes in both preclinical studies and clinical trials when administrated alone,or in combination with other anticancer therapies.In this review,we shed new light on recent advances in the biological characteristics and immunosuppressive functions of MDSCs.We also hope to propose an overview of current MDSCs-targeting therapies so as to provide new ideas for cancer treatment. | Kai Li Houhui Shi Benxia Zhang Xuejin Ou Qizhi Ma Yue Chen Pei Shu Dan Li Yongsheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 2 |
| 2 | Tracking control of a gyroscopically stabilized robot 显示文摘 | YONGSHENG OU YANGSHENG XU | 2004 | International Journal of Robotics and Automation2004，19，3： | 1 |
| 3 | Obstacle avoidance in human-robot cooperative transportation with force constraint显示文摘Dear editor,Robots are often conceived as human-like machines that can interact with humans naturally and safely. Human-robot interaction means that robots can communicate with people,understand their needs, and act accordingly [1]. This interaction is critical when two people are needed to finish a task cooperatively. | Ying ZHANG Chenguang YANG Sheng XU Yongsheng OU | 2023 | Science China(Information Sciences)2023，66，1： | 1 |
| 4 | Line tracking control of a gyroscopically stabilized robot 显示文摘 | Ou Yongsheng Xn Yangsheng | 2004 | Intematlonal Journal of Robotics and Automation2004，19，7： | 1 |
| 5 | Gyroscopically stabilized robot: balance and tracking 显示文摘 | Ou Yongsheng Xu Yangheng | 2004 | International Journal of Advanced Robotic Systems2004，1，1： | 1 |
| 6 | A self-stabilised walking gait for humanoid robots based on the essential model with internal states显示文摘Walking stability is one of the key issues for humanoid robots.A self-stabilised walking gait for a full dynamic model of humanoid robots is proposed.For simplified models,that is,the linear inverted pendulum model and variable-length inverted pendulum model,self-stabilisation of walking gait can be obtained if virtual constraints are properly defined.This result is extended to the full dynamic model of humanoid robots by using an essential dynamic model,which is developed based on the zero dynamics concept.With the proposed method,a robust stable walking for a humanoid robot is achieved by adjusting the step timing and landing position of the swing foot automatically,following its intrinsic dynamic characteristics.This exempts the robot from the time-consuming high-level control approaches,especially when a full dynamic model is applied.How different walking patterns/features(i.e.,the swing foot motion,the vertical centre of mass motion,the switching manifold configuration,etc.)affect the stability of the walking gait is analysed.Simulations are conducted on robots Romeo and TALOS to support the results. | Qiuyue Luo Christine Chevallereau Yongsheng Ou Jianxin Pang Victor De-León-Gómez Yannick Aoustin | 2022 | IET Cyber-Systems and Robotics2022，4，4： | 0 |
| 7 | Impulsive dynamics and stabilization of a single wheel robot显示文摘The impulsive motion of a dynamically stabilized robot—Gyrover, which is a single-wheel gyroscopically stabilized robot is studied. A method based on the D’Alembert-Lagrange principle is proposed to develop the impulsive dynamic model of the single wheel robot. This method that can be used to find ways to investigate a single wheel mobile robot rolling on a rough terrain is tested using the experimental platform Gyrover. The conditions of falling over without actuators are addressed. Simulations that validate the analysis are provided as well. | Ou Yongsheng Wu Xinyu Xu Yangsheng | 2011 | Engineering Sciences2011，9，1： | 0 |
| 8 | A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis显示文摘Pleural and peritoneal metastasis accompanied by malignant pleural effusion(MPE)or malignant ascites(MA)is frequent in patients with advanced solid tumors that originate from the lung,breast,gastrointestinal tract and ovary.Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities.However,malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction.Here,we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA,which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment.Interestingly,we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells.Based on this feature,a novel PD-L1-targeting chimeric switch receptor(PD-L1.BB CSR)was designed,which can bind to PD-L1,switching the inhibitory signal into an additional 4-1BB signal.When co-expressed with a 2nd-generation CAR,PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment,causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models.Further investigations revealed elevated expressions of T-cell activation,proliferation,and cytotoxicity-related genes,and we confirmed that PD-L1 scFv and 4-1BB intracellular domain,the two important components of PD-L1.BB CSR,were both necessary for the functional improvements of CAR-T cells.Overall,our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells.Based on this study,a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis(NCT04684459). | Qizhi Ma Xia He Benxia Zhang Fuchun Guo Xuejin Ou Qiyu Yang Pei Shu Yue Chen Kai Li Ge Gao Yajuan Zhu Diyuan Qin Jie Tang Xiaoyu Li Meng Jing Jian Zhao Zeming Mo Ning Liu Yao Zeng Kexun Zhou Mingyang Feng Weiting Liao Wanting Lei Qiu Li Dan Li Yongsheng Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
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