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| 1 | 伴有假子宫内膜样小管的卵巢Sertoli-Leydig细胞肿瘤(假子宫内膜样Sertoli-Leydig细胞肿瘤)显示文摘 | McCluggage W G Young R H 黄文斌(摘译) | 2007 | 临床与实验病理学杂志2007，23，3： | 8 |
| 2 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 3 | 斯图加特市图书馆显示文摘此项目选址在市中心一个略带坡度的区域,位于斯图加特欧洲区总规划图划定区域的中心地带。这个位于城市盆地内的区域南起斯图加特火车总站,北至北部边境的海尔布隆大街。建成之后,位于Mailander Platz的斯图加特市图书馆由于其独有的设计与规模将会带动周边的发展,未来新的市中心将在此形成规模。它全新的面貌,以浅灰色清水混凝土结构的外墙和边长达45米的立方体磨砂玻璃砖特点呈现,无不向人们宣告了它的存在。 | Eun Young Yi Stefan Müller Günther Marsch 谢作标 | 2013 | 现代装饰2013，，2： | 3 |
| 4 | The oxidative dehydrogenation of ethane over catalysts containing mixed oxides of molybdenum and vanadium显示文摘 | Thorsteinson E M Wilson T P Young F G | 1978 | J Catal1978，52，： | 2 |
| 5 | Methylation of TIMP3 in esophageal squamous cell carcinoma显示文摘AIM: To measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China.METHODS: Cancer cell lines were treated with or without the demethylating reagent 5-aza-2’-deoxycytidine. Methylation of the TIMP3 promoter was assessed in three regions by melt curve analysis and its expression was assessed by real-time RT-PCR. Tumors and proximal resection margins were obtained from 64 patients with esophageal squamous cell carcinoma from a region of high incidence in China. Methylation was assessed by melt curve analysis and expression by immunohistochemistry.RESULTS: Methylation in one of the three promoter regions assessed correlated with gene silencing in esophageal cell lines. A degree of methylation of TIMP3 was found in only four esophageal squamous cell carcinomas, and partial loss of TIMP3 protein expression in just one.CONCLUSION: Methylation and loss of expression of TIMP3 occurs infrequently in esophageal squamous cell carcinoma in a region of high incidence in China. | Eric Smith Neville J De Young Zi-Qiang Tian Maria Caruso Andrew R Ruszkiewicz Jun-Feng Liu Glyn G Jamieson Paul A Drew | 2008 | World Journal of Gastroenterology2008，14，2： | 2 |
| 6 | A qualitative study of specialistnurse support for stroke patients and care-givers athome显示文摘 | Dowswell G Lawler J Young J | 1997 | Clin Rehabi1997，11，4： | 1 |
| 7 | Phospholipid - stabilized nanoparticles of cyclosporine A by rapid expansion from supercritical to aqueous solution显示文摘 | YOUNG T J JOHNSTON K P PACE G W | 2004 | AAPS Pharm Sci Tech2004，5，1： | 1 |
| 8 | Early proterozoic climates and plate motions inferred from major element chemistry of lutites显示文摘 | Nesbitt H W Young G M | 1982 | Nature1982，299，： | 1 |
| 9 | Topical treatment for vaginal candidiasis (thrush) in pregnancy显示文摘 | Young G L Jewell D | 2001 | Cochrane Database Syst Rev2001，4，00： | 1 |
| 10 | Two-state option pricing: binomial models revisited 显示文摘 | JABBOUR G M KRAMIN M V YOUNG S D | 2001 | Journal of Futures Markets2001，21，11： | 1 |
| 11 | A new model of the oceanic e- vaporation duct显示文摘 | BABIN S M YOUNG G S CARTON J A | 1997 | J Appl Meteor1997，36，3： | 1 |
| 12 | Petrogenesis of sediments in the absence of chemical weathering: effects of abrasion and sorting on bulk composition and mineralogy显示文摘 | NESBITT H W YOUNG G M | 1996 | Sedimentology1996，43，： | 1 |
| 13 | Syntheses and properties of low-level melamine modified urea-melamine formaldehyde resin显示文摘 | Young No B Kim M G | 2004 | Journal of Applied Polymer Science2004，93，6： | 1 |
| 14 | Fatty acid genotypes of Virginia-type peanut cultivars显示文摘 | Isleib T G Young C T Knauft D A | 1996 | Crop Sci1996，36，3： | 1 |
| 15 | Aberrant expression of cyclin A and cyclin B1 proteins in oral carcinoma显示文摘 | Kushner J Bradley G Young B | 1999 | JOral Pathol Med1999，28，2： | 1 |
| 16 | Application of a Microbial Selective-Plugging Process at the North Burbank Unit:Prepilot Tests显示文摘 | Jenneman G E Moffitt P D Young G R | 1994 | SPE 27 8271994，，： | 1 |
| 17 | Distribution and possible reproductive role of a gonadotropinreleasing hormone-like peptide in the pond snail, Helisoma trivolvis显示文摘 | YOUNG K G ZALITACH R CHANG J P | 1997 | Soc Neurosci Abstr1997，23，： | 1 |
| 18 | The course of geriatric depression with' reversible dementia':a controlled study显示文摘 | ALEXOPOULOS G MEYERS B S YOUNG R C | 1993 | Am J Psychiatry1993，150，11： | 1 |
| 19 | Increased plasma leptin/fat ration in patients with chronic renal failure:a cause of malnutrition显示文摘 | Young GA Woodrow G Kendall S | 1997 | Nephrol Dial Transplant1997，12，11： | 1 |
| 20 | Ependymoma of the ovary: report of three eases显示文摘 | Kleinman G M Young R H Seully R E | 1984 | Hum Pathol1984，15，7： | 1 |
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