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| 1 | Management of non-variceal upper gastrointestinal tract hemorrhage:Controversies and areas of uncertainty显示文摘Upper gastrointestinal tract hemorrhage(UGIH) remains a common presentation requiring urgent evaluation and treatment.Accurate assessment,appropriate intervention and apt clinical skills are needed for proper management from time of presentation to discharge.The advent of pharmacologic acid suppression,endoscopic hemostatic techniques,and recognition of Helicobacter pylori as an etiologic agent in peptic ulcer disease(PUD) has revolutionized the treatment of UGIH.Despite this,acute UGIH still carries considerable rates of morbidity and mortality.This review aims to discuss current areas of uncertainty and controversy in the management of UGIH.Neoadjuvant proton pump inhibitor(PPI) therapy has become standard empiric treatment for UGIH given that PUD is the leading cause of non-variceal UGIH,and PPIs are extremely effective at promoting ulcer healing.However,neoadjuvant PPI administration has not been shown to affect hard clinical outcomes such as rebleeding or mortality.The optimal timing of upper endoscopy in UGIH is often debated.Upon completion of volume resuscitation and hemodynamic stabilization,upper endoscopy should be performed within 24 h in all patients with evidence of UGIH for both diagnostic and therapeutic purposes.With rising healthcare cost paramount in today's medical landscape,the ability to appropriately triage UGIH patients is of increasing value.Upper endoscopy in conjunction with the clinical scenario allows for accurate decision making concerning early discharge home in low-risk lesions or admission for further monitoring and treatment in higher-risk lesions.Concomitant pharmacotherapy with non-steroidal anti-inflammatory drugs(NSAIDs) and antiplatelet agents,such as clopidogrel,has a major impact on the etiology,severity,and potential treatment of UGIH.Long-term PPI use in patients taking chronic NSAIDs or clopidogrel is discussed thoroughly in this review. | Eric P Trawick Patrick S Yachimski | 2012 | World Journal of Gastroenterology2012，18，11： | 19 |
| 2 | Evidence-based endoscopic management of Barrett's esophagus显示文摘 | Yachimski P Hur C | 2014 | Gastroenterol Rep (Oxf)2014，，： | 1 |
| 3 | Proton pump inhibitors for prophylaxis of nosocomial upper gastrointestinal tract bleeding, effect of standard guidelines on prescribing practice显示文摘 | Yachimski P Farrell E Hunt D | 2010 | Arch Intern Med2010，170，9： | 1 |
| 4 | Proton pump inhibitors for prophylaxis of nosocomial upper gastrointestinal tract bleeding: effect of standard-ized guidelines on prescribing practice显示文摘 | Yachimski PS Farrell EA Hunt DP | 2010 | Arch In-tern Med2010，170，9： | 1 |
| 5 | Gastrointestinal bleeding in the elderly显示文摘 | Yachimski P S Friedman L S | 2008 | Nat Clin Pratt Gastroenterol Hepatol2008，5，1： | 1 |
| 6 | Gastrointestinal bleeding in the elderly显示文摘 | Yachimski PS Friedman LS | 2008 | Nat Clin Pract Gastuoenterol Hepatol2008，5，2： | 1 |
| 7 | Mediastinal cryptococcal abscess diagnosed by EUS-FNA 显示文摘 | Yachimski P Forcione D Faquin W | 2007 | Gastrointest Endosc2007，66，5： | 1 |
| 8 | Upper endoscopy in patients with acute myocardial infarction and upper gastrointestinal bleeding: results of a decision analysis 显示文摘 | YACHIMSKI P HUR C | 2009 | Dig Dis Sci2009，54，4： | 1 |
| 9 | Proton pump inhibitors for prophylaxis of nosocomial upper gastrointestinal lract bleeding, effect of standardized guidelines on prescribing prae tice显示文摘 | Yachimski P Farrell E Hunt D etal | 2011 | Arch Intern Med2011，170，77： | 1 |
| 10 | Upper endoscopy in patienls with acutemyocardial infarction and upper gastrointestinal bleeding: results ofa decision analysis 显示文摘 | Yachimski P Hur C | 2009 | Dig Dis Sci2009，54，： | 1 |
| 11 | Gastrointestinal bleeding in the elderly 显示文摘 | Yachimski PS Friedman LS | 2008 | Nat Clin Pract Gastroenterol Hepatol2008，5，2： | 1 |
| 12 | Subsquamous Intestinal Metaplasia: Implications for Endoscopic Management of Barrett’s Esophagus显示文摘 | Patrick Yachimski Gary W. Falk | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 1 |
| 13 | Update on hepatitis B and C coinfection in HIV显示文摘 | Patrick Yachimski MD Raymond T. Chung MD | 2005 | Current Infectious Disease Reports2005，，4： | 1 |
| 14 | Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging显示文摘 | Melissa J. Suter Benjamin J. Vakoc Patrick S. Yachimski Milen Shishkov Gregory Y. Lauwers Mari Mino-Kenudson Brett E. Bouma Norman S. Nishioka Guillermo J. Tearney | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 15 | Patient predictors of esophageal stricture development after photodynamic therapy 显示文摘 | Yachimski P Puricelli WP Nishioka NS | 2008 | Clin Gastroenterol Hepatol2008，6，3： | 1 |
| 16 | Upper Endoscopy in Patients with Acute Myocardial Infarction and Upper Gastrointestinal Bleeding: Results of a Decision Analysis显示文摘 | Patrick Yachimski Chin Hur | 2009 | Digestive Diseases and Sciences2009，，4： | 1 |
| 17 | Gastrointestinal bleeding in the elderly显示文摘 | Yachimski PS Friedman LS | 2008 | Nat Clin Pract Gastroenterol Hepatol2008，5，2： | 1 |
| 18 | Proton pump inhibitors given before endoscopy for upper gastrointestinal bleeding do not improve survival,rebleeding or need for surgery显示文摘 | Yachimski P | 2011 | Evid Based Med2011，16，1： | 1 |
| 19 | Upper endoscopy in patients with acute myocardial infarction and upper gastrointestinal bleeding: results of a decision analysis 显示文摘 | YACHIMSKI P HUR C | 2009 | Dig Dis Sci2009，54，4： | 1 |
| 20 | Upper endoscopy in patients with acute myocardial infarction and upper gastrointestinal bleeding:results of a decision analysis显示文摘 | Patrick Yachimski Chin Hut | | 0，，04： | 1 |
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