|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An integrated theoretical fouling model for convective heating surfaces in coal-fired boilers显示文摘 | Pan Yadi Si Fengqi Xu Zhigao | | 0，，02： | 1 |
| 2 | Scheduling multi-tenant cloud workflow tasks with resource reliability显示文摘Resource reliability is crucial in scheduling workflow instances for different tenants.Both cloud resource reliability and precedence constraints in workflows bring about great challenges for these kinds of scheduling problems.In this paper,we construct a hybrid resource reliability model which is adaptively evaluated in every time window.The objective is to optimize the QoS(quality of service)for tenants which is measured by the introduced AISE(all instance success entropy)index.A scheduling algorithmic framework is proposed for the studied workflows which consider cloud resource reliability.Deadline and budget division(BD)methods are presented to divide deadlines and budgets of instances into those of tasks.A tenant sequence method is developed to determine the order of tenants.A task allocation strategy is investigated to schedule tasks that are ready to appropriate available resources.Parameters and algorithm component candidates are statistically calibrated over a comprehensive set of random instances using the analysis of variance technique.The performance of the proposed algorithm is also evaluated in practical instances. | Xiaoping LI Dongyuan PAN Yadi WANG Ruben RUIZ | 2022 | Science China(Information Sciences)2022，65，9： | 0 |
| 3 | Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)显示文摘A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease(NAFLD),coupled with hepatitis and insulin resistance.Yet the details of the underlying mechanisms are not fully understood.Here,we unraveled that the expression of the transcription factor Zbtb18 is markedly decreased in the livers of both patients and murine models of NAFLD.Hepatic Zbtb18 knockout promoted NAFLD features like impaired energy expenditure and fatty acid oxidation(FAO),and induced insulin resistance.Conversely,hepatic Zbtb18 overexpression alleviated hepato-steatosis,insulin resistance,and hyperglycemia in mice fed on a high-fat diet(HFD)or in diabetic mice.Notably,in vitro and in vivo mechanistic studies revealed that Zbtb18 transcriptional activation of Farnesoid X receptor(FXR)mediated FAO and Clathrin Heavy Chain(CLTC)protein hinders NLRP3 inflammasome activity.This key mechanism by which hepatocyte’s Zbtb18 expression alleviates NAFLD and consequent liver fibrosis was further verified by FXR’s deletion and forced expression in mice and cultured mouse primary hepatocytes(MPHs).Moreover,CLTC deletion significantly abrogated the hepatic Zbtb18 overexpression-driven inhibition of NLRP3 inflammasome activity in macrophages.Altogether,Zbtb18 transcriptionally activates the FXR-mediated FAO and CLTC expression,which inhibits NLRP3 inflammasome’s activity alleviating inflammatory stress and insulin resistance,representing an attractive remedy for hepatic steatosis and fibrosis. | Lei Zhang Jiabing Chen Xiaoying Yang Chuangpeng Shen Jiawen Huang Dong Zhang Naihua Liu Chaonan Liu Yadi Zhong Yingjian Chen Kaijia Tang Jingyi Guo Tianqi Cui Siwei Duan Jiayu Li Shangyi Huang Huafeng Pan Huabing Zhang Xiaoqiang Tang Yongsheng Chang Yong Gao | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
| 4 | ATP Mimics pH-Dependent Dual Peroxidase-Catalase Activities Driving H_(2)O_(2) Decomposition显示文摘Adenosine triphosphate(ATP)is produced mainly in the mitochondrion,and its primary task is to function as a ubiquitous energy currency to meet the cellular metabolic demands in biological systems.Thus far,its potential role as performing enzymatic functions has not been elucidated. | Ying Shi Menghuan Tang Chaoqun Sun Yadi Pan Li Liu Yijuan Long Huzhi Zheng | 2019 | CCS Chemistry2019，1，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员