| 1 | Exploring the potential impact of nutritionally actionable genetic polymorphisms on idiopathic male infertility:a review of current evidence显示文摘Infertility affects about 15%of the world's population.In 40%-50%of infertile couples,a male factor underlies the problem,but in about 50%of these cases,the etiology of male infertility remains unexplained.Some clinical data show that lifestyle interventions may contribute to male reproductive health.Cessation of unhealthy habits is suggested for preserving male fertility;there is growing evidence that most preexisting comorbidities,such as obesity and metabolic syndrome,are highly likely to have an impact on male fertility.The analysis of genetic polymorphisms implicated in metabolic activity represents one of the most exciting areas in the study of genetic causes of male infertility.Although these polymorphisms are not directly connected with male infertility,they may have a role in specific conditions associated with it,that is,metabolic disorders and oxidative stress pathway genes that are potentially associated with an increased risk of male infertility due to DNA and cell membrane damage.Some studies have examined the impact of individual genetic differences and gene-diet interactions on male infertility,but their results have not been synthesized.We review the current research to identify genetic variants that could be tested to improve the chances of conceiving spontaneously through personalized diet and/or oral vitamin and mineral supplementation,by examining the science of genetic modifiers of dietary factors that affect nutritional status and male fertility. | Sinda Mahbouli Charlotte Dupont Yaelle Elfassy Eric Lameignere Rachel Levy | 2021 | Asian Journal of Andrology2021，23，5： | 1 |
| 3 | Expression of adipokines in seminal fluid of men of normal weight显示文摘Dear Editor,Infertility affects about 48.5 million couples worldwide,and a male disorder is estimated to be a causative or contributing factor in 20%-50%of cases.^1 Notably,increasing data support the view that obese men are at higher risk of fertility disorders.^2 As is known,obesity is defined by an excess of white adipose tissue,currently recognized as being able to secrete many endocrinologically active molecules called adipokines. | Alice Bongrani Yaelle Elfassy Jean Sebastien Brun Christelle Rame Namya Mellouk Soraya Fellahi Jean Philippe Bastard Rachel Levy Claudine Vasseur Pascal Froment Joelle Dupont | 2019 | Asian Journal of Andrology2019，21，5： | 1 |
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