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| 1 | BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts显示文摘Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation.Osteocytes or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,respectively.Bone morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of osteoclastogenesis.However,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains unclear.In the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in osteoblasts.In vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult mice.Although global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult phase.Atoh8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow cells.Atoh8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ratio.Moreover,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression ratio.These results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption. | Yuhei Yahiro Shingo Maeda Masato Morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono Noboru Taniguchi | 2020 | Bone Research2020，8，3： | 6 |
| 2 | 癌症病人心目中好护士的质性研究显示文摘目的了解癌症病人心目中好护士的形象。方法对25位癌症病人进行深入访谈,现场录音,按现象学研究的方法整理分析资料。结果好护士是经常与病人沟通、关心病人、态度好、技术好、有责任心的护士。结论将爱心和专业技术相结合才是病人心目中的好护士。 | 王海芳 Michiko Yahiro 彭美慈 薛小玲 | 2007 | 护士进修杂志2007，22，1： | 6 |
| 3 | Electrical properties and reducibilities of ceria-rare earth oxide system and their application to solid oxide fuel cell 显示文摘 | Hedinori Yahiro Koichi Eguchi Hiromichi Arai | 1989 | Solid State Ionics1989，36，： | 2 |
| 4 | Effect of calcination temperature on the catalytic activity of copper supported on γ-alumina for the water-gas-shift reaction显示文摘 | YAHIRO H NAKAYA K YAMAMOTA K SAILI K YAMAURA H | 2006 | Catal Commun2006，7，4： | 1 |
| 5 | Photocatalytic Partial Oxidation of Alpha-methylstyrene over Ti O2Supported on Zeolites显示文摘 | Yahiro H Miyamoto T Watanabe N | 2007 | Catalysis Today2007，120，2： | 1 |
| 6 | Serum and urine markers of bone metabolism during the year after hip fracture 显示文摘 | Yu -Yahiro JA Michael RH Dubin NH | 2001 | J Am Geriatr Soc2001，49，： | 1 |
| 7 | Influence of sulfur dioxide on catalytic removal of nitric oxide over copper ion-exchanged ZSM-5 zeolite显示文摘 | Iwamoto M Yahiro H Shundo S | 1991 | Applied Catalysis1991，69，1： | 1 |
| 8 | Recoverable degradation phenomena of quantum efficiency in organic EL devices显示文摘 | Yahiro M Zou D Tsutsui T | 2000 | Synth Met2000，，： | 1 |
| 9 | Cu-ZSM-5 zeolite as highly active catalyst for removal of nitrogen monoxide from emission of diesel engines显示文摘 | Sato S Yu-u Y Yahiro H | 1991 | Applied Catalysis1991，70，1： | 1 |
| 10 | Removal of Nitrogen Monoxide on Copper Ion - exchanged Zeolite by Pressure Swing Adsorption 显示文摘 | HIDENORI Yahiro NORTAKE Mizuno | 1993 | Langmuir1993，9，： | 1 |
| 11 | Copper ion-exchanged zeolite catalysts in deNOx reaction显示文摘 | Yahiro H Iwamoto M | 2001 | Applied Catalysis A:Gene-ral2001，222，12： | 1 |
| 12 | Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA显示文摘 | Yahiro K Satoh M Nakano M | 2012 | J Biol Chem2012，287，31： | 1 |
| 13 | Cu-ZSM-5 zeolite as highly active catalyst for removal of nitrogen monoxide from emission of diesel engines显示文摘 | Sato S Yu Y Yahiro H | 1991 | Applied Catalysis1991，70，1： | 1 |
| 14 | 显示文摘 | Yahiro H Shundo S | 1991 | Appl Catal1991，69，： | 1 |
| 15 | Nitration of alkanes with nitric acid by vanadium-substituted polyoxometalates显示文摘 | Shinachi S Yahiro H Yamaguchi K | 2004 | Chemistry-A European Journal2004，10，24： | 1 |
| 16 | C kit is required for cardiomyocyte terminal differentiation显示文摘 | Li M Naqvi N Yahiro E | | 0，，06： | 1 |
| 17 | Development of coiling temperature control system on hot strip mill显示文摘 | Kazuhire yahiro jujiro yamasaki | 1991 | Kawasaki Steel Technical Report1991，24，4： | 1 |
| 18 | Cu - ZSM - 5 zeolite as highly active catalysts for removal of nitrogen monoxide from emission of diesel engines显示文摘 | Sato S Yu Y Yahiro H | 1991 | Appl Catal1991，70，1： | 1 |
| 19 | Mechanism of the cardioprotective effect of inhibition of the renin-angiotensin system on ischemia/reperfusion-induced myocardial injury显示文摘 | Wang LX Ideishi M Yahiro E | 2001 | Hypertens Res2001，24，2： | 1 |
| 20 | Study on factors controlling catalytic activity for low-temperature water-gas-shift reaction on Cu-based catalysts显示文摘 | Sagata K Imazu N Yahiro H | 2013 | Catalysis Today2013，201，： | 1 |
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