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| 1 | Expression of Interleukin-11 and Interleukin-11 receptor a in human colorectal adenocarcinoma; Immunohistochemical analyses and correlation with clinicopathological factors显示文摘AIM: There is strong evidence that interleukin-11 (IL-11) is involved in the regulation of tumor progression, cellular growth and differentiation. Recently, interleukin-11 receptor (IL-11R) has been detected on some cancer cells. In this study, we investigated the expression of IL-11 and IL-11R in colorectal adenocarcinoma. METHODS: To elucidate the involvement of IL-11 and IL-11Ra in human intestinal adenocarcinomas, we examined 115 cases of surgically resected human colonic adenocarcinoma and 11 cases of adenoma by immuno-histochemistry and Western blotting. RESULTS: Among 115 cases of adenocarcinoma, 100 cases (87.0%) showed positive staining in the cytoplasm of carcinoma cells for the IL-11, and 87 cases (75.6%) were positive for the IL-11Ra. Six cases (54.5%) and four cases (36.4%) of 11 adenomas were positive for IL-11 and IL-11Ra, respectively. The expression of IL-11Ra correlated with the histological differentiation (P=0.033503), the depth of tumor invasion (P=0.006395), Dukes' classification (P= 0.015648) and lymphatic invasion (P=0.003865). However, the expression of IL-11Ra was not correlated with the venous invasion and the presence of lymph node metastasis. The expression of IL-11 was not correlated with any clinicopathological factors. In Western blot analysis, two human colorectal carcinoma cell lines and four tissues of surgically resected human carcinoma expressed both IL-11 and IL-11Ra proteins. CONCLUSION: IL-11 and IL-11Ra are highly expressed in human colorectal adenocarcinoma and the IL-11Ra expression is correlated with clinicopathological factors. These findings suggest that the expression of IL-11Ra is an important factor for the invasion of human colorectal adenocarcinoma. | Kazuyuki Yamazumi Toshiyuki Nakayama Takafumi Kusaba Chun Yang Wen Ayumi Yoshizaki Yuichi Yakata Takeshi Nagayasu Ichiro Sekine | 2006 | World Journal of Gastroenterology2006，12，2： | 7 |
| 2 | Expression of pSTAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis 显示文摘 | Yakata Y Nakayama T Yoshizaki A | 2007 | Int J Oncol2007，30，2： | 1 |
| 3 | Expression of p-STAT3 in human gastric carcinoma: significant correlatian in turnout inva- sion and prognosis 显示文摘 | Yakata Y Nakayama T Yoshizaki A | 2007 | Int J Oncol2007，30，2： | 1 |
| 4 | Expression of p-STAT3 in human gastric carcinoma:significant correlation in tumour invasion and prognosis显示文摘 | Yakata Y Nakayama T Yoshizaki A | 2007 | Int J Oncol2007，30，2： | 1 |
| 5 | Expression of p-STAT3 in human gastric carcinoma: significant cor- relation in tumour invasion and prognosis 显示文摘 | Yakata Y Nakayama T Yoshizaki A | 2007 | Int J On- col2007，30，2： | 1 |
| 6 | Aquaporin-11 containing a divergent NPA motif has normal water channel activity显示文摘 | Hiroaki Y Ishibashi K | 2007 | Biochim Biophys Acta2007，1768，3： | 1 |
| 7 | Aquaprin-Ⅱ containing a divergent NPA motif has normal water channel activity 显示文摘 | Yakata K Hiroaki Y Ishibashi K | 2007 | Biochim Biophys Acta2007，1768，68： | 1 |
| 8 | Expression of p-ST A TI in human gastric carcinoma: significant correlation in tumour invasion and prognosis显示文摘 | Yakata Y Nakayama T Y oshizaki A | 2007 | IntJ Oncol2007，30，2： | 1 |
| 9 | Expression of PSTAT3 in human gastric carcinoma correlation in tumor invasion and prognosis 显示文摘 | Yakata Y Nakajama T Yoshizaki A | 2007 | Tint J Oncol2007，30，2： | 1 |
| 10 | Use of polymeras chain reaction monitor minimal residual disease in acute lymphoblastic leukemia patients显示文摘 | Yakata S Hansen-Hagge TE Ludwig WD | 1991 | Blood1991，77，4： | 1 |
| 11 | Aquaprin-11 Containing a Divergent NPA Motif Has Normal Water Channel Activity显示文摘 | Yakata K Hiroaki Y Ishibashi K | 2007 | Biochim Biophys Acta2007，1768，： | 1 |
| 12 | Expression of p-STAT3 in human gastric carcinomas:significant correlation in tumor invasion and prognosis显示文摘 | Yakata Y Nakayama T Yoshizaki A | 2007 | Int J Oncol2007，30，3： | 1 |
| 13 | Expression of p-STAT3 in human gastric carcinoma: Significant correlationin tumour invasion and prognosis显示文摘 | Yuichi Yakata Toshiyuki Nakayama Ayumi Yoshizaki Takafumi Kusaba Kenichiro Inoue Ichiro Sekine | 2007 | International Journal of Oncology2007，，： | 1 |
| 14 | Aquaporin-11 containing a divergent NPA motif has normal water channel activity显示文摘 | Yakata K | 2007 | Biochim Biophys Acta2007，1768，3： | 1 |
| 15 | Expression of p- STAT3 in human gastric carcinomas:significant correlation in tumor invasion and prognosis显示文摘 | Yakata Y Nakayama T Yoshizaki A | 2007 | Int J Oneol2007，30，3： | 1 |
| 16 | Extensive osteolysis of the mandible following devitalization of a tooth by arsenic trioxide显示文摘 | Yakata H Azumi T Kawasaki T | 1985 | J Oral Maxillofac Surg1985，43，： | 1 |
| 17 | Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis显示文摘 | Yakata Y Nakayama T Yoshizaki A | 2007 | Int J Oncol2007，30，2： | 1 |
| 18 | Expression of p-STAT3 in human gastric carcinoma:significant correlation in tumour invasion and prognosis显示文摘 | YAKATA Y NAKAYAMA T YOSHIZAKI A | 2007 | Int J Oncol2007，30，2： | 1 |
| 19 | Determination of urinary cortisol and 6 beta-hydroxycortisol by high performance liquid chromatography显示文摘 | Nakamura J Yakata M | 1985 | Clin Chim Acta1985，149，23： | 1 |
| 20 | Aquaporin- 11 containing a divergent NPA motif has normal water channel activity Biochim显示文摘 | Yakata K Hiroaki Y Ishibashi K | 2007 | Biophys Aeta2007，1768，3： | 1 |
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