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10篇 您的检索式：作者名="Yakisich"

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		题名	作者	年代	出处	被引量
	1	Early inhibition of DNA synthesis in developing rat cerebral cortex by purine analogues olomoucine and roscovitine 显示文摘	Yakisich JS Siden A Vargas Ⅵ	1998	Biochem Biophys Res Commun1998，243，：	1
	2	Disulfiram Is a Potent in Vitro Inhibitor of DNA Topoisomerases显示文摘	J.Sebastian Yakisich ?ke Sidén Peter Eneroth Mabel Cruz	2001	Biochemical and Biophysical Research Communications2001，，2：	1
	3	Rapid inhibition of ongoing DNA synthesis in human glioma tissue by genistein 显示文摘	Yakisich J S Ohlsson T Lindblom I	2009	Oncol Rep2009，22，3：	1
	4	Natural Products Targeting Autophagy via the PI3K/Akt/mTOR Pathway as Anticancer Agents显示文摘	SUN H WANG Z YAKISICH J S	2012	Anticancer Agents Med Chem2012，13，7：	1
	5	Deletion of the Tetrahymena thermophila rDNA replication fork barrier region disrupts macronuclear rDNA excision and creates a fragile site in the micronuclear genome 显示文摘	Yakisich JS Kapler GM	2006	Nucleic Acids Res2006，34，2：	1
	6	Natural Products Targeting Autophagy via the PI3K1 AktimTOR Pathway as Anticancer Agents显示文摘	Sun H Wang Z Yakisich J S	2013	Anticancer Agents Med Chern2013，13，7：	1
	7	Natural products targeting autophagy via the PI3K/Akt/mTOR pathway as anticancer agents显示文摘	Sun H Wang Z Yakisich JS	2013	Anticancer Agents Med Chem2013，13，7：	1
	8	Natural Products Targeting Autophagy via the PI3K/Akt/m TOR pathway as anticancer agents显示文摘	Sun H Wang Z Yakisich JS	2012	Anticancer Agents Med Chem2012，13，7：	1
	9	The effect of phosphoinositide 3-kinase inhibitors on programmed nuclear degradation in Tetrahymena and fate of surviving nuclei 显示文摘	YAKISICH J S KAPLER G M	2004	Ceil Death Differ2004，11，：	1
	10	Alternative models of cancer stem cells: The stemness phenotype model, 10 years later显示文摘The classical cancer stem cell(CSCs)theory proposed the existence of a rare but constant subpopulation of CSCs.In this model cancer cells are organized hierarchically and are responsible for tumor resistance and tumor relapse.Thus,eliminating CSCs will eventually lead to cure of cancer.This simplistic model has been challenged by experimental data.In 2010 we proposed a novel and controversial alternative model of CSC biology(the Stemness Phenotype Model,SPM).The SPM proposed a non-hierarchical model of cancer biology in which there is no specific subpopulation of CSCs in tumors.Instead,cancer cells are highly plastic in term of stemness and CSCs and non-CSCs can interconvert into each other depending on the microenvironment.This model predicts the existence of cancer cells ranging from a pure CSC phenotype to pure non-CSC phenotype and that survival of a single cell can originate a new tumor.During the past 10 years,a plethora of experimental evidence in a variety of cancer types has shown that cancer cells are indeed extremely plastic and able to interconvert into cells with different stemness phenotype.In this review we will(1)briefly describe the cumulative evidence from our laboratory and others supporting the SPM;(2)the implications of the SPM in translational oncology;and(3)discuss potential strategies to develop more effective therapeutic regimens for cancer treatment.	Vivek Kaushik Yogesh Kulkarni Kumar Felix Neelam Azad Anand Krishnan V Iyer Juan Sebastian Yakisich	2021	World Journal of Stem Cells2021，13，7：	0

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