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| 1 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 2 | Brain metabolite changes in subcortical regions after exposure to cuprizone for 6 weeks:potential implications for schizophrenia显示文摘 | Yan G Xuan YH Dai ZZ | 2015 | Neurochem Res2015，40，： | 1 |
| 3 | Genome-wide analysis of regulatory proteases sequences identified through bioinformatics data mining in Taenia solium显示文摘 | Yan HB Lou ZZ Li L | 2014 | BMC Genomics2014，4，15： | 1 |
| 4 | Human coronavirus NL63 in hospitalized children with respiratory infection: a 2-year study from Chongqing, China 显示文摘 | Xin C Yong ZZ Yan L | 2012 | Indian Pediatr2012，49，10： | 1 |
| 5 | A Class of Ratio Estimators of A Finite Population Mean Using Two Auxiliary Variables显示文摘 | Lu Jl Yan Zz | 2014 | Plos One2014，9，2： | 1 |
| 6 | The structure of a glycoside hydrolase family 81 endo-β-1,3-glucanase显示文摘 | Zhou P Chen ZZ Yan QJ | 2013 | Acta Crystallographica Section D: Biological Crystallography2013，69，10： | 1 |
| 7 | Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults, a large-scale, randomised, double-blind placebo- controlled, phase 3 trial 显示文摘 | Zhu FC Zhang J Zhang XF Zhou C Wang ZZ Huang SJ Wang H Yang CL Jiang HM Cai JP Wang YJ Ai X Hu YM Tang Q Yao X Yan Q Xian YL Wu T Li YM Miao J Ng MH Shih JW Xia NS | 2010 | Lancet2010，376，： | 1 |
| 8 | Isolation and identification of subgingival anaerobic bacteria in periodontitis patients显示文摘 | Yan J Chen LL Zhu ZZ | 1993 | J Zhejiang Med Uni1993，22，： | 1 |
| 9 | Genome-wide analysis of regulatory proteases sequences identified through bioinformatics data mining in Taenia solium显示文摘 | Yan HB Lou ZZ Li L | 2014 | BMC genomics2014，15，： | 1 |
| 10 | Effects of Al on the splenic immune function and NE in rats显示文摘 | Chong W Jing L Yan ZZ | 2013 | Food Chem Toxicol2013，62，： | 1 |
| 11 | Real-time mosaicing for multiple live video streams 显示文摘 | Wanigasekara NR ZENG YQ YAN ZZ | 2003 | Journal of Image and Graphics2003，，： | 1 |
| 12 | Brain-derived neurotro- phic factor signaling mediates the antidepressant-like effect of the total flavonoids of alpiniae oxyphyllae fruc- tus in chronic unpredictable mild stress mice 显示文摘 | Yan T Wu B Liao ZZ | 2016 | Phy- totherapy Research2016，30，9： | 1 |
| 13 | An alternative technique of sensitive questions survey显示文摘 | Yan ZZ Nie ZK | 2005 | Chinese Journal of Applied Probability and Statistics2005，21，3： | 1 |
| 14 | Beneficial effect of taurine on testicular ischemia-reperfusion injury in rats显示文摘 | Wei SM Yan ZZ Zhou J | 2007 | Urology2007，70，6： | 1 |
| 15 | The Arabidopsis PAPltranscription factor plays an important role in the enrichment ofphenolic acids in Salvia miltiorrhiza显示文摘 | Zhang Y Yan YP Wang ZZ | 2010 | Agric Food Chem2010，581，12： | 1 |
| 16 | Iptakalim protects against ischemic injury by improving neurovascular unit function in the mouse brain 显示文摘 | Ji J Yan H Chen ZZ | 2015 | Clin Exp Pharmacol Physiol2015，42，： | 1 |
| 17 | Human coronavirus NL63 in hospitalized children with respiratory infection: a 2-year study from Chongqing, China显示文摘 | Xin C Yong ZZ Yan L | 2012 | Indian Pediatr2012，49，10： | 1 |
| 18 | Association between tumor necrosis faetor-ct 308G/A gene polymorphism and silicosis susceptibility: A Meta-Analysis显示文摘 | Li ZZ Xue J Yan SP | 2013 | PLOS ONE2013，8，76： | 1 |
| 19 | Role of cAMP-responsive element modulator-tau (CREMtau) in ipsilateral testicular injury after unilateral testicular torsion-detorsion显示文摘 | Wei SM Yan ZZ Zhou J | | 0，，06： | 1 |
| 20 | Separation of Cobalt from Iron by Chloride Hydrolysis at Elevated Temperature显示文摘The hydrolysis rate of Co-bearing ferrous chloride at elevated temperature and the conditionsof separation of Co from Fe have been investigated. The hydrolysis process is comprised of theinterfacial chemical reaction and the intra-grain diffusion. At the stage under the control of theinterfacial chemical reaction, the apparent rate constant k equals to 198.79exp(-80.57/RT). Theeffects of the temperature, the partial pressure ratio of water vapor and the reaction time on theCo recovery and the separation of Co from Fe are examined. The optimum hydrolysis conditionsare determined. | Ma, KY Zhu, ZZ Yan, CY | 1997 | Journal of Materials Science & Technology1997，13，5： | 0 |
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