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| 1 | 上海地区1998-2002年川崎病流行病学特征显示文摘目的对上海地区川崎病发病情况进行调查,了解中国发达地区川崎病的流行病学特征。方法参照日本流行病学调查方案,制作统一调查表和诊断指南,调查对象为1998年1月1日至2002年12月31日上海地区50家有儿科临床服务的二级及二级以上医院收治的所有川崎病病例。结果调查表回收率100%。将18例不符合诊断标准要求者剔除后,对768例川崎病病例进行分析。上海地区5岁以下儿童川崎病发病率呈逐年增高趋势,1998年为16.79/10万,1999 年为25.65/10万,2000年为28.16/10万,2001年为28.05/10万,2002年为36.76/10万。男女性别比为1.83:1;发病年龄为1个月至18.8岁(中位数1.8岁),发病年龄高峰为9.6个月;全年均可发病,但以春夏之交较多见。主要症状表现为发热持续5 d以上者最为常见(99.3%),其后依次为口唇、口腔黏膜损害(83.5%)、指(趾)端脱皮(82.9%)、皮疹(81.0%)、结膜充血(78.4%)、颈部淋巴结肿大(69.3%)、肢端充血硬肿(48.1%)和肛周脱皮(45.2%)。心血管损害发生率为25. 4%,以冠状动脉扩张最为常见(68%);其次为冠状动脉瘤(10%)。急性期病死率为0.26%,死因为冠状动脉瘤破裂和急性心力衰竭。再发率为1.82%。结论上海地区川崎病发病率明显低于日本,但高于西方国家。发病率呈逐年增高趋势,性别分布和心血管损害与其他报道相似。发病季节分布与北京地区的报道相似,但与其他报道不同。 | 黄国英 马晓静 黄敏 陈树宝 黄美蓉 邱定忠 过仲珍 蒋瑾瑾 周晓迅 于清 桂永浩 宁寿葆 张拓红 杜忠东 Hiroshi Yanagawa Tomisaku Kawasaki | 2006 | 中国循证儿科杂志2006，1，1： | 62 |
| 2 | A prospective randomized trial of lafutidine vs rabeprazole on post-ESD gastric ulcers显示文摘AIM:To compare the effects of rabeprazole and lafutidine on post-endoscopic submucosal dissection(ESD) gastric ulcers.METHODS:Patients with gastric tumors indicated for ESD were prospectively studied.After ESD,all patients were treated with intravenous omeprazole for the first 3 d.Patients were then randomly assigned to oral lafutidine or rabeprazole.Ulcer size,ulcer size reduction rate,and ulcer stage were evaluated 4 wk later.Occurrence of complication was monitored throughout the 4-wk period.RESULTS:Sixty five patients were enrolled in the study,and 60 patients were subjected to the final analysis.In the lafutidine group(30 lesions in 29 patients),initial and 4-wk post-ESD ulcer sizes were 33.3 ± 9.2 and 10.5 ± 4.8 mm,respectively.In the rabeprazole group(34 lesions in 31 patients),the values were 34.7 ± 11.3 and 11.8 ± 6.7 mm,respectively.Ulcer size reduction rates in lafutidine and rabeprazole groups were 32.3% and 33.5%,respectively(P=0.974).Ulcer stage 4 wk post-ESD did not differ significantly between the two groups(P=0.868).Two cases in the rabeprazole group and no cases in the lafutidine group developed ulcer bleeding during the oral dose period,although the difference of bleeding rate between the two groups was not statistically significant(P=0.157).CONCLUSION:Lafutidine and rabeprazole have equivalent therapeutic effects on post-ESD gastric ulcers. | Tomohiko Richard Ohya Hiroki Endo Kei Kawagoe Tatsuro Yanagawa Katsuhiro Hanawa Ken Ohata Masako Asayama Kantaro Hisatomi Takuma Teratani Toshiaki Gunji Hajime Sato Nobuyuki Matsuhashi | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 7 |
| 3 | Fibrinogen degradation product levels on arrival for trauma patients requiring a transfusion even without head injury显示文摘BACKGROUND: There have been few reports on the clinical significance of the fibrinogen degradation product(FDP) level in trauma patients with and without head injury. We retrospectively analyzed trauma patients with or without head injury to investigate the clinical signifi cance of the FDP level.METHODS: From April 2013 to June 2015, a medical chart review was retrospectively performed for all patients with trauma. The exclusion criteria included patients who did not receive a transfusion. The patients were divided into two groups: a FDP>100 group, which included patients who had an FDP level on arrival over 100 ng/m L, and a FDP≤100 group.RESULTS: The ratio of open fractures and the prothrombin ratio in the FDP>100 group were significantly smaller than those observed in the FDP≤100 group. The average age, ratio of blunt injury, Injury Severity Score(ISS), volume of transfusion and mortality ratio in the FDP>100 group were signifi cantly greater than those in the FDP≤100 group. There was a weakly positive correlation between the FDP level and ISS(R=0.35, P=0.002), but it was not associated with the transfusion volume. The results of an analysis excluding patients with head injury showed a similar tendency.CONCLUSION: The FDP levels may be a useful biochemical parameter for the initial evaluation of the severity of trauma and mortality even in blunt traumatized patients without head injury or with stable vital signs. | Youichi Yanagawa Kouhci Ishikawa Kci Jitsuiki Toshihiko Yoshizawa Yasumasa Oodc Kazuhiko Omori Hiromichi Ohsaka | 2017 | World Journal of Emergency Medicine2017，8，2： | 4 |
| 4 | Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function显示文摘Enteroviral 感染能导致扩大心肌症(DCM ) ,它是世界范围的心血管的死亡的一个主要原因。然而,病原的机制充分没被阐明。浆液反应因素(SRF ) 是控制许多目标基因的表示的一个心脏充实抄写管理者,包括涉及可收缩的仪器和立即的早反应的那些,以及 microRNAs 那沉默心脏的规章的因素的表示。在心的 SRF 的大美人导致心脏的可收缩的基因表示的 downregulation 和 DCM 的开发。这研究的目标是在导致 enterovirus 的心脏的机能障碍和前进理解 SRF 的角色到 DCM。这里,我们报导 SRF 被劈开跟随老鼠心和有教养的 cardiomyocytes 的 enteroviral 感染。这劈开被心脏特定的可收缩、规章的基因的损害心脏的功能和 downregulation 伴随。由印射的抗体 epitope 和指导地点的 mutagenesis 的进一步的调查证明那 SRF 劈开通过编码病毒的朊酶 2A 的行动发生在它的 transactivation 领域的区域。而且,我们证明 SRF 的那劈开分裂它从 DNA 有约束力的领域的 transactivation 领域,导致调停 SRF 的基因 transactivation 的混乱。除了功能的 SRF 的损失,最后,我们报导 SRF 劈开产品的 N 终端碎片能也充当一个主导否定的抄写因素,它多半为 DNA 绑定与本国的 SRF 竞争。我们的结果建议病毒感染由损害心功能的机制并且可以提供新治疗学的策略改善 DCM 的心肌的损坏和前进。 | Jerry Wong Jingchun Zhang Bobby Yanagawa Zongshu Luo Xiangsheng Yang Jiang Chang Bruce McManus Honglin Luo | 2012 | Cell Research2012，22，2： | 3 |
| 5 | The influence of manipulations to alter ambient GABA concentrations on the hypnotic and immobilizing actions produced by sevoflurane, propofol, and midazolam显示文摘 | Koichi Nishikawa Kazuhiro Kubo Hideaki Obata Yuchio Yanagawa Shigeru Saito | 2011 | Neuropharmacology2011，，： | 2 |
| 6 | 为与窒息肠塞痛联系的肠的局部缺血的察觉的动态 CT 的动脉的阶段的用途显示文摘 AIM:To clarify the usefulness of arterial phase scans in contrast computed tomography (CT) imaging of stran-gulation ileus in order to make an early diagnosis. METHODS:A comparative examination was carried out with respect to the CT value of the intestinal tract wall in each scanning phase, the CT value of the content in the intestinal tract, and the CT value of ascites fluid in the portal vein phase for a group in which ischemia was observed (Group Ⅰ) and a group in which ischemia was not observed (Group N) based on the pathological findings or intra-surgical findings. Moreover, a comparative examination was carried out in Group Ⅰ subjects for each scanning phase with respect to average differences in the CT values of the intestinal tract wall where ischemia was suspected and in the intestinal tract wall in non-ischemic areas. RESULTS:There were 15 subjects in Group Ⅰ and 30 subjects in Group N. The CT value of the intestinal tract wall was 41.8 ± 11.2 Hounsfield Unit (HU) in Group Ⅰ and 69.6 ± 18.4 HU in Group N in the arterial phase, with the CT value of the ischemic bowel wall being significantly lower in Group Ⅰ. In the portal vein phase, the CT value of the ischemic bowel wall was 60.6 ± 14.6 HU in Group Ⅰ and 80.7 ± 17.7 HU in Group N, with the CT value of the ischemic bowel wall being significantly lower in Group Ⅰ; however, no significant differences were observed in the equilibrium phase. The CT value of the solution in the intestine was 18.6 ± 9.5 HU in Group Ⅰ and 10.4 ± 5.1 HU in Group N, being signifi-cantly higher in Group Ⅰ. No significant differences were observed in the CT value of the accumulation of ascites fluid. The average difference in the CT values between the ischemic bowel wall and the non-ischemic bowel wall for each subject in Group Ⅰ was 33.7 ± 20.1 HU in the arterial phase, being significantly larger compared to the other two phases. CONCLUSION:This is a retrospective study using a small number of subjects; however, it suggests that there is a possibility that CT scanning in the arterial phase is useful for the early diagnosis of strangulation ileus. | Gaku Ohira Kiyohiko Shuto Tsuguaki Kono Takayuki Tohma Hisashi Gunji Kazuo Narushima Shunsuke Imanishi Takeshi Fujishiro Tohru Tochigi Toshiharu Hanaoka Hideaki Miyauchi Naoyuki Hanari Hisahiro Matsubara Noriyuki Yanagawa | 2012 | World Journal of Radiology2012，4，11： | 2 |
| 7 | Angiosarcoma of the scalp diagnosed by the presence of neck inflammation:a case report显示文摘Angiosarcoma is an uncommon malignancy,which spread out from the endothelial cells of vessels.Scalp angiosarcoma with cervical lymph node metastasis is particularly rare.This article describes a rare case of angiosarcoma of the scalp,presenting as neck inflammation.Imaging procedures such as computed tomography(CT),magnetic resonance image(MRI) and ultrasonography(US) were not sufficient to diagnose this case.A needle biopsy provided an effective and accurate diagnosis of cervical lymph node metastasis.Additional observation and physical examination was required to diagnose the origin of the primary cancerous lesion.Once the angiosarcoma diagnosis was confirmed histologically,sequential weekly and monthly docetaxel(DTX) treatment was effective in preventing reoccurrence.Nonetheless,the optimization of angiosarcoma treatment remains a future goal.Although patients generally describe pain and swelling at the primary lesion site,this patient complained only of painful neck inflammation,without any indication of pain or swelling of the scalp.A revised diagnostic protocol should note that cervical lymph node metastasis of unknown primary origin may result from angiosarcoma of the scalp. | Rei Karube Hiroyoshi Sasaki Keiji Shinozuka Yasuhiro Fujisawa Toru Yanagawa Kenji Yamagata Kojiro Onizawa Fujio Otsuka Hiroki Bukawa | 2012 | International Journal of Oral Science2012，4，3： | 2 |
| 8 | Etiology and clinical study of community-acquired pneumonia in 157 hospitalized children显示文摘 | Takeshi Tajima Eiichi Nakayama Yasuo Kondo Fumie Hirai Hiroaki Ito Taketoshi Iitsuka Mei Momomura Hirokazu Kutsuma Yuri Kodaka Naomi Funaki Yukishige Yanagawa Kimiko Ubukata | 2006 | Journal of Infection and Chemotherapy2006，，6： | 2 |
| 9 | CTLA - 4 gene polymorphism associated with Graves 'disease in a Caucasian population 显示文摘 | Yanagawa T Hidaka Y Guimaraes V | 1995 | Clin Endocrinol Metab1995，80，1： | 1 |
| 10 | Relationship between aging and vitamin E 显示文摘 | Takasaki M Yanagawa K Shinozaki K | 2002 | Nippon Ronen Igakkai Zasshi2002，39，5： | 1 |
| 11 | Serum levels of interleukin 6 in patients with lung cancer显示文摘 | Yanagawa H Sone S Takahashi Y | 1995 | Br J Cancer1995，71，5： | 1 |
| 12 | Results oftenation wide epidemiologic survey of Kawasaki diseasein 1995 and 1996 in Japan显示文摘 | Yanagawa H Nakamura Y Yashiro M | 1998 | Pediatrics1998，102，6： | 1 |
| 13 | Linear and nonlinear optical properties of sol-gel-derived Au nanometer-particle-doped alumina显示文摘 | Hosoya Y Suga T Yanagawa T | 1997 | JAppl Phys1997，81，： | 1 |
| 14 | Cell-cycle-cultured rice cells 显示文摘 | Takase T Yanagawa Y Komatsy S | 2003 | Journal of Plant Research2003，116，： | 1 |
| 15 | Orange fruit colour in Capsicum due to deletion of capsanthin-capsombin synthesis gene显示文摘 | Lang Y Q Yanagawa S Sasanuma T et ol | 2004 | Breeding Science2004，54，： | 1 |
| 16 | Incidence survey of kawasaki disease in 1997 and 1998 in Japan显示文摘 | Yanagawa H Nakamura Y Yashiro M | | 0，，： | 1 |
| 17 | A comparative study on photcatalytic hydrogen transfer and catalytic hydrogenation of norbornadiene and quadricyclane catalyzed by显示文摘 | Akioka T Inoue Y Yanagawa A | 2003 | Journal of Molecular Catalysis A:Chemical2003，202，： | 1 |
| 18 | The classification ofanatomic variations in the perigastric vessels by dual-phaseCT to reduce intraoperative bleeding during laparoscopicgastrectomy 显示文摘 | Natsume T Shuto K Yanagawa N | 2011 | Surg Endosc2011，25，： | 1 |
| 19 | Joint strength and interfacial microstructure between Sn-Ag-Cu and Sn-Zn-Bi solders and Cu substrate显示文摘 | Akio Yanagawa Hiroto | 2004 | Science and Technology of Advanced Materials2004，5，： | 1 |
| 20 | Prostaglandin El ismore effective,when incorporated in lipid microspheres for treat-ment of peripheral vascular disease显示文摘 | Mizushima Y Yanagawa A Hoshik | 1996 | J Pharm pharmucol1996，35，3： | 1 |
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