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| 1 | A comparison between intravenous and peritoneal route on liver targeted uptake and expression of plasmid delivered by Glyco-poly-L-lysine显示文摘AIM To compare the effects of intravenous routeand peritoneal route on liver targeted uptake andexpression of plasmid delivered by galactose-terminal glyco-poly-L-lysine(G-PLL).METHODS The plasmid pTM/MMP-1 which couldbe expressed in eukaryotic cells was bound to G-PLL,and was then transferred into Wistar rats byintravenous and intraperitoneal injection.Theexpression and distribution of the plasmid wereobserved at different time periods by in situhybridization and immunohistochemistry.RESULTS The plasmid could be expressedsignificantly within 24 h after being transferred invivo by both intravenous and intraperitonealroutes.One week later the expression began todecrease,and could still be observed three weekslater.Although both the intravenous andintraperitoneal route could target-specificallydeliver the plasmid to the liver,the effect of theformer was better as compared to that of the latter.CONCLUSION Intravenous route is better for livertargeted uptake and expression of G-PLL-boundplasmids than the peritoneal route. | Yang CQ Wang JY Fang GT Liu JJ Guo JS | 2000 | World Journal of Gastroenterology2000，6，4： | 4 |
| 2 | Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver显示文摘AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat liver.METHODS After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by intravenousroute.At different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and immunohistochemistry.RESULTS The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three weeks.Both liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the liver.CONCLUSION G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver. | Yang, CQ Wang, JY He, BM Liu, JJ Guo, JS | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 3 | Tolerance of epicardial coronary endothelial and smooth muscle to hyperkalemia显示文摘 | Yang CQ Wilson GJ | 1994 | Ann Thorac Surg1994，57，： | 1 |
| 4 | Multi - Band Wavelet for Fusing SPOT Panchromatic and Multispectral Images显示文摘 | SHI WZ ZHU CQ YANG XM | 2003 | Photogrammetric Engineering and Remote Sensing2003，69，5： | 1 |
| 5 | Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity 显示文摘 | Hui LR Wu CQ Yang BH | 2008 | Toxicology and Applied Pharmacology2008，232，： | 1 |
| 6 | Depolaring cardiac arrest and EDHF-mediated hyperpolarization and relaxation in coronary arteries:the effect and mechanism显示文摘 | He GW Yang CQ | 1997 | J Thorac Cardiovasc Surg1997，113，5： | 1 |
| 7 | Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease显示文摘 | Wang SL Wang ZR Yang CQ | 2012 | Exp Ther Med2012，4，6： | 1 |
| 8 | Cytoreductive surgery and hyper- thermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase 111 randomized clinical trial 显示文摘 | Yang X J Huang CQ Suo T | 2011 | Ann Surg Oncol2011，18，6： | 1 |
| 9 | Superiority of hyperpolarizing to depolarizing cardioplegia in protection of corconary endothelial function显示文摘 | HE GW YANG CQ | 1997 | J Thorac Cardiovasc Surg1997，114，： | 1 |
| 10 | Effects of RP58866 on transmem- brahe K eurrents in mammalian ventrieular myoeytes 显示文摘 | Yang BF Li GR Xu CQ | 1999 | Acta Pp- harmacol Sin1999，20，： | 1 |
| 11 | Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients 显示文摘 | Pang YH Zheng CQ Yang XZ | 2007 | Cell Immunol2007，248，2： | 1 |
| 12 | Dietary Patterns Modulate the Risk of Non -Alcoholic Fatty Liver Disease in Chinese Adults 显示文摘 | Yang CQ Shu L Wang S | 2015 | Nutrients2015，7，6： | 1 |
| 13 | Vesicular glutamate transporter- 3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats 显示文摘 | Yang CQ Wei YY Leng YX | 2012 | Dig Dis Sci2012，57，： | 1 |
| 14 | Tolerance of epicardial coronary endothelium an smooth muscle to hyperkalemia显示文摘 | Yang CQ Wilson GJ | 1994 | Ann Thorac Surg1994，57，： | 1 |
| 15 | Smooth muscle and endothelial function of arterial grafts for coronary artery bypass surgery 显示文摘 | He GW Yang Q Yang CQ | 2002 | Clin Exp Pharmacol Physiol2002，29，8： | 1 |
| 16 | Inhabition of vasoconstriction by potassium channel opene aprikalim in human conduit arteries显示文摘 | He GW Yang CQ | 1997 | Br J Clin Pharmacol11997，44，4： | 1 |
| 17 | Influence of flueonamle on the pharmacokinetics of omeprazole in healthy volonteers显示文摘 | Kang BC Yang CQ Cho HK | 2002 | Biopharm Drug Dispoe2002，23，2： | 1 |
| 18 | Use of verapamil and nitroglycerin solution in prepartion of radial artery for coronary grafting显示文摘 | Yang CQ | 1996 | Ann Thorac Sury1996，61，： | 1 |
| 19 | An Example-based Mapping Method显示文摘 | Yang Y Chute Cq | 1994 | In ACM Transation on Information Systems1994，，7： | 1 |
| 20 | Daily temperature and mortality:a study of distributed lag non-linear effect and effect modification in Guangzhou显示文摘 | Yang J Ou CQ Ding Y | 2012 | Environ Health2012，11，： | 1 |
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