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| 1 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 2 | Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents显示文摘AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF treatment.METHODS:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected retrospectively.They failed to show response or were intolerant to conventional treatments,including steroids or immunomodulators.Screening measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were identified.RESULTS:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used adalimumab.Before anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of patients.Thirty patients(8%)had LTBI.Sixteen cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF treatment.LTBI(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk factors.CONCLUSION:Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD.The considerable burden of TB and marked immunosuppression might be attributed to this risk. | Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong Kook Lee Dong Wook Lee Sung Kook Kim Tae Oh Kim Jonghun Lee Hyung Wook Kim Sam Ryong Jee Seun Ja Park Hyun Jin Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 5 |
| 3 | Bevacizumab as a second- or later-line of treatment for metastatic colorectal cancer显示文摘AIM: To determine the efficacy of bevacizumab in patients with metastatic colorectal cancer (MCRC) who have failed prior chemotherapy without bevacizumab. METHODS: Between March 2002 and June 2010, 40 patients in South Korea with MCRC who were treated with bevacizumab plus chemotherapy as a second or later-line treatment were analyzed retrospectively for their overall response rate (ORR), overall survival (OS), and progression-free survival (PFS). The tumor responses were assessed using the RECIST (Response Evaluation Criteria in Solid Tumors) guidelines. RESULTS: All of the patients had progressed under prior chemotherapy without bevacizumab. Three patients (7.5%) exhibited an ORR, twenty one patients (52.5%) exhibited stable disease (SD), and fifteen patients (37.5%) exhibited disease progression. The median duration of the OS and PFS were 14.0 and 6.13 mo respectively. The median OSs were 16.60, 14.07 and 13.00 mo for second-line, third-line and fourth- or later-line treatments, respectively. The median PFSs were 7.23, 7.30 and 3.87 mo for the second-line, third-line and fourth- or later-line treatments, respectively. CONCLUSION: In patients with MCRC, bevacizumab combined chemotherapy may be beneficial during second- or later-line treatment. | Lee Chun Park Ho Sup Lee Seong Hoon Shin Seun Ja Park Moo In Park Sung Yong Oh Hyuk Chan Kwon Jin ho Baek Young Jin Choi Myoung Joo Kang Yang Soo Kim | 2012 | World Journal of Gastroenterology2012，18，10： | 3 |
| 4 | Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn's disease显示文摘AIM To evaluate the risk factors for postoperative recurrence after primary bowel resection in a cohort of Korean Crohn's disease(CD) patients.METHODS This study included 260 patients with no history of previous bowel surgery who underwent primary surgery for CD between January 2000 and December 2010 at Asan Medical Center(Seoul, South Korea). The median follow-up period was 101 mo.RESULTS During the follow-up period, 66 patients(25.4%) underwent a second operation for disease recurrence.At 1, 5 and 10 years after the first operation, the cumulative rate of surgical recurrence was 1.1%, 8.3% and 35.9% and clinical recurrence occurred in 1.2%, 23.6% and 68.1%, respectively. In multivariate analysis, undergoing an emergency operation was a significant risk factor for surgical recurrence-free survival(SRFS) [HR = 2.431, 95%CI: 1.394-4.240, P = 0.002], as were the presence of perianal disease after the first operation(HR = 1.715, 95%CI: 1.005-2.926, P = 0.048) and history of smoking(HR = 1.798, 95%CI: 1.088-2.969, P = 0.022). The postoperative use of antitumor necrosis factor(TNF) agents reduced SRFS risk(HR = 0.521, 95%CI: 0.300-0.904, P = 0.02).CONCLUSION History of smoking, postoperative perianal disease and undergoing an emergency operation were independent risk factors for surgical recurrence. Using anti-TNF agents may reduce surgical recurrence. | Kwan Mo Yang Chang Sik Yu Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Sang Hyoung Park Byong Duk Ye Suk-Kyun Yang Jin Cheon Kim | 2017 | World Journal of Gastroenterology2017，23，38： | 3 |
| 5 | Disruption of the retinoblastoma pathway by small interfering RNA and ectopic expression of the catalytic subunit of telomerase lead to immortalization of human ovarian surface epithelial cells显示文摘 | Yang G Rosen DG Colacino JA | 2007 | Oncogene2007，26，10： | 1 |
| 6 | Acetylcholine pro-motes the proliferation and collagen gene expressionof myofibroblastic hepatic stellate cells显示文摘 | Oben JA Yang S Lin H | 2003 | BiochemBiophys Res Commun2003，300，： | 1 |
| 7 | Effect of Chungkookiang supplementation on obesity and atherosclerotic indices in overweight/obese subjects: 12-week, randomized, doubleblind, placebo- controlled clinical trial显示文摘 | Back HI Kim SR Yang JA | 2011 | J Med Food2011，14，53： | 1 |
| 8 | Norepinephrine andneuropeptide Y promote proliferation and collagengene expression of hepatic myofibroblastic stellatecells显示文摘 | Oben JA Yang S Lin H | 2003 | Biochem Biophys Res Commun2003，302，： | 1 |
| 9 | Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice显示文摘 | Oben JA Roskams T Yang S | 2003 | Biochem Biophys Res Commun2003，308，2： | 1 |
| 10 | Cold-inducible RNA binding proteinis required for the expression of adhesion molecules and embryonic cellmovement in Xenopus laevis显示文摘 | Peng Y Yang PH Tanner JA | 2006 | Biochem Biophys Res Commun2006，344，1： | 1 |
| 11 | An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy显示文摘 | Yang CS Khawly JA Hainsworth DP | | 0，，： | 1 |
| 12 | GI262570, a peroxisome proliferator-activated receptor {gamma} agonist, changes electrolytes and water reabsorption from the distal nephron in rats显示文摘 | Chen L Yang B MeNuhy JA | 2005 | J Pharmacol Exp Ther2005，312，2： | 1 |
| 13 | Lethal injuries and timeto death in a level I trauma center 显示文摘 | Acosta JA Yang JC Winchell RJ | 1998 | J Am Coll Surg1998，186，5： | 1 |
| 14 | CD117,CK20,TTF-1 and DNA topoisomerase II antigen expression in small cell tumors显示文摘 | Yang DT Holden JA Florell SR | 2004 | J Cutan Pathol2004，31，3： | 1 |
| 15 | Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells 显示文摘 | Oben JA Yang S Lin H | 2003 | Biochem Biophys Res Commun2003，300，1： | 1 |
| 16 | Alphal-antitrypsin deficiency allele carriers among lung cancer patients显示文摘 | Wentzlaff KA Katzmann JA | 1999 | Cancer Epidemiol Bionmark Prev1999，8，4： | 1 |
| 17 | Comparing whole body (18)F - 2 - deoxyglucose positron emission tomography and technetium - 99m methylene diphosphonate bone scan to detect bone metas- tases in patients with breast cancer 显示文摘 | Yang SN Liang JA Lin FJ | 2002 | J Cancer Res Clin On- col2002，128，： | 1 |
| 18 | Spectrum of toxic hepatitis following intentional paraquat ingestion: analysis of 187 cases显示文摘 | Chin‐Jung Yang Ja‐Liang Lin Dan‐Tzu Lin‐Tan Cheng‐Hao Weng Ching‐Wei Hsu Shen‐Yang Lee Shwu‐Hua Lee Chia‐Ming Chang Wey‐Ran Lin Tzung‐Hai Yen | 2012 | Liver Int2012，，9： | 1 |
| 19 | A phase I study of anti-kinase insert domaincontainingreceptor antibody,IMC-1C11,in patientswith liver metastases from colorectal carcinoma显示文摘 | Posey JA Ng TC Yang B | 2003 | Clin Cancer Res2003，9，： | 1 |
| 20 | Preparation of activated carbons from walnut shells via vacuum chemical activation and their application for methylene blue removal 显示文摘 | Yang JA Qiu KQ | 2010 | Chem Eng J2010，165，1： | 1 |
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