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您的检索式：作者名="Yang Junkun"
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| 1 | Antimicrobial peptide LL-37 forms complex with bacterial DNA to facilitate blood translocation of bacterial DNA and aggravate ulcerative colitis显示文摘Bacterial DNA(bacDNA) is frequently found in serum of patient with ulcerative colitis(UC) and Crohn's disease, even blood bacterial culture is negative. How bacDNA evades immune elimination and is translocated into blood remain unclear. Here, we showed that bacDNA avoids elimination and disables bacteriakilling function of antimicrobial peptide LL-37(Cramp in mice) by forming complex with LL-37, which is inducible after culture with bacteria or bacterial products. Elevated LL-37-bacDNA complex was found in plasma and lesions of patients with UC. LL-37-bacDNA promoted inflammation by inducing Th1, Th2 and Th17 differentiation and activating toll-like receptor-9(TLR9). The complex also increased paracellular permeability, which possibly combines its inflammatory effects to promote local damage and bacDNA translocation into blood. Cramp-bacDNA aggravated mouse colitis severity while interference with the complex ameliorated the disease. The study identifies that inflammatogenic bacDNA utilizes LL-37 as a vehicle for blood translocation and to evade immune elimination. Additionally, bacteria may make a milieu by releasing bacDNA to utilize and resist host antimicrobial peptides as a ‘trojan horse'. | Zilei Duan Yaqun Fang Yang Sun Ning Luan Xue Chen Mengrou Chen Yajun Han Yizhu Yin James Mwangi Junkun Niu Kunhua Wang Yinglei Miao Zhiye Zhang Ren Lai | 2018 | Science Bulletin2018，63，20： | 4 |
| 2 | Energy recovery on petro-chemical complexes through heat integration显示文摘 | Feng Xiao Pu Jing Yang Junkun | 2011 | Applied En-ergy2011，88，5： | 1 |
| 3 | Early detection of joint degeneration in the subtalar and talonavicular joints secondary to ankle instability in a mouse model显示文摘Background:Many patients with ankle sprain have secondary subtalar and talonavicular injuries,which have a great impact on their life and body.Purpose::This study aimed to investigate the biomechanical impact of ankle instability on the subtalar joint(STJ)and talonavicular joint(TNJ)using a mouse model to enhance the clinical understanding of early stage secondary joint degeneration.Methods:Twenty four 8-week old male C57BL/6 J mice were randomly allocated to three groups.Both the calcaneofibular ligament(CFL)and anterior talofibular ligament(ATFL)of the left ankle were cut off in the CFLþATFL group to simulate severe ankle instability while only the CFL was excised in the CFL group to mimic moderate ankle instability.No operation was done in SHAM group to simulate the normal ankle.Then histological analysis,atomic force microscopy(AFM)–based nanoindentation tests and inspection by scanning electron microscopy(SEM)were used to assess the degree of joint degeneration in the tibiotalar joint(TTJ),STJ and TNJ of three groups.Results:A significant increase of histological score for both CFL and CFLþATFL group was demonstrated in the TTJ,compared with the SHAM group.While in the STJ and TNJ,the histological score only increased for CFLþATFL group.AFM-based nanoindentation results demonstrated significant differences in elastic modulus between all groups in the TTJ,while for the STJ and TNJ,only the comparison between the CFLþATFL group and SHAM group was considered statistically significant.The SEM presented signs of cracking and disintegration within the subchondral bone(SCB)interface in the CFLþATFL group only.Conclusions:The findings indicate that severe ankle instability resulted in early degeneration of the STJ and TNJ in a mouse model,which may provide referential values for clinical practice. | Zhi Chen Ting Liang Junkun Li Chao Gao Fan He Zongping Luo Huilin Yang Hongtao Zhang Jia Yu | 2021 | Medicine in Novel Technology and Devices2021，，3： | 0 |
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