|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | KAII, a putative marker for metastatic potential in human breast cancer 显示文摘 | Yang X Welch DR Philips KK | 1997 | Cancer Lett1997，119，2： | 1 |
| 3 | ITS sequence analysis used for molecular identification of the Bupleurum species from northwestern China显示文摘 | Yang ZY Chao Z Huo KK | | 0，，： | 1 |
| 4 | Agricultural application and environmental degradation of photo- biodegradable polyethylene mulching films 显示文摘 | Wang YZ Yang KK Wang XL | 2004 | Journal of Polymers and the Environment2004，12，1： | 1 |
| 5 | Papillary carcinoma arising from thyroglossal duct cyst with thyroid and lateral neck metastasis显示文摘 | Yang SI Park KK Kim JH | 2013 | Int J Surg Case Rep2013，4，8： | 1 |
| 6 | Mammalian Mstl and Mst2 kinases play essential roles in organ size control and tumor suppression显示文摘 | Song H Mak KK Topol L Yun K Hu J Garrett L Chen Y Park O Chang J Simpson RM Wang CY Gao B Jiang J Yang Y | 2010 | Proc Natl Acad Sci U S A2010，107，4： | 1 |
| 7 | Association between reproductive and hormonal factors and age-related maculopathy in postmenopausal women显示文摘 | Snow KK Cote J Yang W | 2002 | Am J Ophthalmol2002，134，： | 1 |
| 8 | Vascular effects of synthetic or natural progestagen combined with conjugated equine estro gen in healthy postmenopausal women显示文摘 | Koh KK Jin DK Yang SH | 2001 | Circulation2001，103，15： | 1 |
| 9 | Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells显示文摘 | Yang X Sheares KK Davie N | 2002 | Am J Respir Cell Mol Biol2002，27，6： | 1 |
| 10 | Surface heterogeneity of modified active carbons 显示文摘 | Yang KK Wang XL Wang YZ A | 2007 | Industrial and Engineering Chemistry2007，13，4： | 1 |
| 11 | Presence of antibiotic resistant commensal bacteria in samples from agricultural,city,and national park environments evaluated by standard culture and real-time PCR methods 显示文摘 | Yang H Byelashov OA Geornaras I Goodridge LD Nightingale KK Belk KE Smith GC Sofos JN | 2010 | Can J Microbiol2010，56，9： | 1 |
| 12 | Macrophage inhibitory cy- tokine-1 activates AKT and ERK-1/2 via the transactiva- tion of ErbB2 in human breast and gastric cancer cells显示文摘 | Kim KK Lee JJ Yang Y | 2008 | Carcinogenesis2008，29，4： | 1 |
| 13 | Poly(p-DIOXANONE) and its copolymers 显示文摘 | Yang KK Wang XL Wang YZ | 2002 | Polymer Reviews2002，42，3： | 1 |
| 14 | Glutathione S- transferasemicrol regulates vascular smooth muscle cell proliferation, migration, and oxidative stress显示文摘 | Yang Y Parsons KK Chi L | 2009 | Hypertension2009，54，6： | 1 |
| 15 | Reliability of the lung to-head ratio as a predictor of outcome in fetuses with isolated left congenital diaphragmatic hernia at gestation outside 24-26 weeks显示文摘 | Yang SH Nobuhara KK Keller RL | 2007 | Am J Obstet Gynecol2007，197，： | 1 |
| 16 | Thyroid metastasis from breast carci- noma accompanied by papillary thyroid carcinoma 显示文摘 | Yang SI Park KK Kim JH | 2014 | Case Rep Oncol2014，7，： | 1 |
| 17 | Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a poten- tial monoamine oxidase inhibitor 显示文摘 | Zhi KK Yang ZD Shi DF | 2014 | Fitoterapia2014，98，： | 1 |
| 18 | Macrophage inhibitory cy- tokine-1 activates AKT and ERK-1/2 via the transactiva- tion of ErbB2 in human breast and gastric cancer cells显示文摘 | Kim KK Lee J J Yang Y | 2008 | Carcinogenesis2008，29，4： | 1 |
| 19 | Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells显示文摘 | Kim KK Lee JJ Yang Y | 2008 | Carcinogenesis2008，29，4： | 1 |
| 20 | KAI1, a putative marker for metastasic potential in human breast cancer 显示文摘 | YANG X Welch DR PHILLIPS KK | 1997 | Cancer Lett1997，119，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员