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| 1 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 2 | Isolation and characterization of bipotent liver progenitor cells from adult mouse显示文摘 | Li WL Su J Yao YC Tao XR Yan YB Yu HY Wang XM Li JX Yang YJ Lau JT HuYP | 2006 | 中国生物学文摘2006，20，5： | 26 |
| 3 | Effects of radical cholecystectomy on nutritional and immune status in patients with gallbladder carcinoma显示文摘INTRODUCTION Carcinoma of the gallbladder is the most commonneoplasm in biliary tract,and its incidence has beenrising in recent years.The rate of correct diagnosisin early gallbladder carcinoma has been raised afterthe wide use of CT,ultrasound scans and frozensection examination.Now radical cholecystectomyis advocated as the best management for patientswith early gallbladder carcinoma.In the | Jiao XY Shi JS Wang JS Yang YJ He P | 2000 | World Journal of Gastroenterology2000，6，3： | 6 |
| 4 | Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages显示文摘 | Liu,YJ Lu,SH Xu,B Yang,RC Ren,Q Liu,B Lu,M Yan,FY Han,ZB Han,ZC | 2005 | 中国生物学文摘2005，19，3： | 2 |
| 5 | Pyroelectric spectrum in Pb(Zr,Sn,Ti)O3 antiferroelectric- ferroelectric ceramics显示文摘The pyroelectric effect of phase transition induced with temperature in Nb-modified Pb(Zr,Sn,Ti)O3 antiferroelectric-ferroelectric ceramics is studied. Experimental results reveal that the phase transitions are accompanied with marked pyroelectric peaks, there exists the close relation between the type of phase transition and the shape of pyroelectric peak. Because of the variations of phase transition, various pyroelectric spectra result. The pyroelectric spectrum can display the polarization effect and some inferior phase transitions with temperature variations, such as antiferroelectric AFEA-AFEB or ferroelectric FEL-FEH transition, which are not detected by the conventional dielectric measurement. | Feng, YJ Xu, Z Yang, TQ Yao, X | 2000 | Chinese Science Bulletin2000，45，13： | 2 |
| 6 | Step Sintering of Microwave Heating and MicrowavePlasma Heating for Alumina Ceramics显示文摘The invention of microwave induced plasma during microwave heating makes it possible to confine plasma inside a crucible, in the pressure range of 1.33 Pa to 0.5 MPa, and above 900℃.In this study, the step sintering of microwave heating and microwave plasma heating (SSMP)was proposed. In this process, microwave heating and plasma heating was ingeniously combined in one chamber, and vacuum was unnecessary for microwave induced plasma. In the first step, the microwave energy directly heated alumina ceramics to a given temperature. above which microwave will mainly ionize the gas and sustain a plasma. Then the plasma further heated alumina ceramics to the final temperature to finish sintering. Maintaining the advantages of microwave heating and plasma heating, this step sintering approach will overcome the limitation of both processes for processing ceramics. and it will be suitable for sintering all kinds of ceramics in | Zhang, JS Cao, L Yang, YJ Diao, YX Shen, XX | 1999 | Journal of Materials Science & Technology1999，15，5： | 2 |
| 7 | Proliferation of neural stem cells correlates with Wnt-3 protein in hypoxlcischemic neonate rats after hyperbaric oxygen therapy 显示文摘 | Wang XL Yang YJ Xie M | 2007 | Neuroreport2007，18，16： | 1 |
| 8 | Different effects of post-conditioning on myocardial no-reflow in the normal and hypercholesterolemic mini-swines显示文摘 | Zhao JL Yang YJ You SJ | 2007 | Microvasc Res2007，73，2： | 1 |
| 9 | Effects of intracoronary autologous bone marrow cells on left ventricular function in acute myocardial infarction: a systematic review and recta- analysis for randomized controlled trials显示文摘 | Kang S Yang YJ Li CJ | 2008 | Coron Artery Dis2008，19，5： | 1 |
| 10 | Oral immunization of haemagguluti- nin I-IS expressed in plant endoplasmic reticulum with adjuvant sap- onin protects mice against highly pathogenic avian influenza A virus infection 显示文摘 | Lee G Na YJ Yang BG | 2015 | Plant Biotechnology Journal2015，13，1： | 1 |
| 11 | Mechanistic investigation of immunosuppression in patients with condyloma acuminata显示文摘 | Shi YJ Yang J Yang W | 2013 | Mol Med Rep2013，8，2： | 1 |
| 12 | Adjuvant capecitabine and oxalipla- tin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Bang YJ Kim YW Yang HK | 2012 | Lancet2012，379，9813： | 1 |
| 13 | Improved genome annotation for Zymomonasmobilis 显示文摘 | Yang S Pappas KM Hauser LJ Land ML Chen GL Hurst GB PanC Kouvelis VN Typas MA Pelletier DA Klinqeman DM Chanq YJ Samatova NF Brown SD | 2009 | Nat Biotechnol2009，27，10： | 1 |
| 14 | Role of interleukin- 18 in acute lung inflammation induced by gut ischemia reperfusion 显示文摘 | Yang YJ Shen Y Chen SH | 2005 | World J Gastroenterol2005，11，29： | 1 |
| 15 | Different Effects of Tirofiban and Aspirin plus Clopidogrel on Myocardial No-Reflow in a Mini-swine Model of Acute Myocardial Infarction and Reperfusion 显示文摘 | Yang YJ Zhao JL You SJ | 2006 | Heart2006，92，8： | 1 |
| 16 | Quantification of plasma hTERT DNA in hepatoeellular carcinoma patients by quantitative fluorescent polymerase chain reaction显示文摘 | Yang YJ Chen H Huang P | 2011 | Clin Invest Med2011，34，4： | 1 |
| 17 | Tongxinluo decreases ap- optosis of mesenchymal stem cells concentration-depend- ently under hypoxia and serum deprivation conditions through the AMPK/eNOS pathway显示文摘 | Li N Yang YJ Cui HH | 2014 | J Cardiovasc Phar- macol2014，63，3： | 1 |
| 18 | Autoantibodies against phospholipase A2 receptor in Korean patients with membranous nephropathy显示文摘 | Oh YJ Yang SH Kim DK | 2013 | PloS One2013，8，62： | 1 |
| 19 | Refined frontalis fascial sling with proper lid crease Formation for blepharopoptosis 显示文摘 | Chen TH Yang YJ Chen YR | 1997 | Plast Re- constr Sung1997，99，1： | 1 |
| 20 | Hyperbaric oxygen induces endogenous neural stem cells to proliferate and differentiate in hypoxic - ischemic brain damage in neonatal rats显示文摘 | Yang YJ Wang XL Yu XH | 2008 | Undersea Hyperb Med2008，35，2： | 1 |
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