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| 1 | Effect of vernalization on tuberization and flowering in the Tibetan turnip is associated with changes in the expression of FLC homologues显示文摘The turnip(Brassica rapa var. rapa) is a biennial crop that is planted in late summer/early fall and forms fleshy tubers for food in temperate regions. The harvested tubers then overwinter and are planted again the next spring for flowering and seeds. FLOWERING LOCUS C(FLC) is a MADS-box transcription factor that acts as a major repressor of floral transition by suppressing the flowering promoters FT and SOC1. Here we show that vernalization effectively represses tuber formation and promotes flowering in Tibetan turnip. We functionally characterized four FLC homologues(BrrFLC1,FLC2, FLC3, and FLC5), and found that BrrFLC2 and BrrFLC1 play a major role in repressing flowering in turnip and in transgenic Arabidopsis. In contrast, tuber formation was correlated with BrrFLC1 expression in the hypocotyl and was repressed under cold treatment following the quantitative downregulation of BrrFLC1. Grafting experiments of non-vernalized and vernalized turnips revealed that vernalization independently suppressed tuberization in the tuber or hypocotyl of the rootstock or scion, which occurred in parallel with the reduction in BrrFLC1 activity. Together, our results demonstrate that the Tibetan turnip is highly responsive to cold exposure, which is associated with the expression levels of BrrFLC genes. | Yan Zheng Landi Luo Yuanyuan Liu Yunqiang Yang Chuntao Wang Xiangxiang Kong Yongping Yang | 2018 | Plant Diversity2018，40，2： | 7 |
| 2 | Drag Reduction in the Mouthpart of a Honeybee Facilitated by Galea Ridges for Nectar-Dipping Strategy显示文摘 | Chuchu Li Jianing Wu Yunqiang Yang Rengao Zhu Shaoze Yan | 2015 | Journal of Bionic Engineering2015，12，1： | 4 |
| 3 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 4 | Genome-wide analysis indicates diverse physiological roles of the turnip (Brassica rapa var. rapa) oligopeptide transporters gene family显示文摘Oligopeptide transporters(OPTs) encode integral membrane-localized proteins and have a broad range of substrate transport capabilities. Here, 28 BrrOPT genes were identified in the turnip. Phylogenetic analyses revealed two well-supported clades in the OPT family, containing 15 BrrOPTs and 13 BrrYSLs.The exon/intron structure of OPT clade are conserved but the yellow stripe-like(YSL) clade was different.The exon/intron of the YSL clade possesses structural differences, whereas the YSL class motifs structure are conserved. The OPT genes are distributed unevenly among the chromosomes of the turnip genome.Phylogenetic and chromosomal distribution analyses revealed that the expansion of the OPT gene family is mainly attributable to segmental duplication. For the expression profiles at different developmental stages, a comprehensive analysis provided insights into the possible functional divergence among members of the paralog OPT gene family. Different expression levels under a variety of ion deficiencies also indicated that the OPT family underwent functional divergence during long-term evolution.Furthermore. BrrOPT8.1, BrrYSL1.2, BrrYSL1.3, BrrYSL6 and BrrYSL9 responded to Fe(Ⅱ) treatments and BrrYSL7 responded to calcium treatments, BrrYSL6 responded to multiple treatments in root, suggesting that turnip OPTs may be involved in mediating cross-talk among different ion deficiencies. Our data provide important information for further functional dissection of BrrOPTs, especially in transporting metal ions and nutrient deficiency stress adaptation. | Yanan Pu Danni Yang Xin Yin Qiuli Wang Qian Chen Yunqiang Yang Yongping Yang | 2018 | Plant Diversity2018，40，2： | 3 |
| 5 | The Honeybee's Protrusible Glossa is a Compliant Mechanism显示文摘 | Yunqiang Yang Jianing Wu Rengao Zhu Chuchu Li Shaoze Yan | 2017 | Journal of Bionic Engineering2017，14，4： | 3 |
| 6 | Multidimensional and quantitative interlinking approach for Linked Geospatial Data显示文摘Linked Data is known as one of the best solutions for multisource and heterogeneous web data integration and discovery in this era of Big Data.However,data interlinking,which is the most valuable contribution of Linked Data,remains incomplete and inaccurate.This study proposes a multidimensional and quantitative interlinking approach for Linked Data in the geospatial domain.According to the characteristics and roles of geospatial data in data discovery,eight elementary data characteristics are adopted as data interlinking types.These elementary characteristics are further combined to form compound and overall data interlinking types.Each data interlinking type possesses one specific predicate to indicate the actual relationship of Linked Data and uses data similarity to represent the correlation degree quantitatively.Therefore,geospatial data interlinking can be expressed by a directed edge associated with a relation predicate and a similarity value.The approach transforms existing simple and qualitative geospatial data interlinking into complete and quantitative interlinking and promotes the establishment of high-quality and trusted Linked Geospatial Data.The approach is applied to build data intra-links in the Chinese National Earth System Scientific Data Sharing Network(NSTI-GEO)and data-links in NSTI-GEO with the Chinese Meteorological Data Network and National Population and Health Scientific Data Sharing Platform. | Yunqiang Zhu A-Xing Zhu Jia Song Jie Yang Min Feng Kai Sun Jingqu Zhang Zhiwei Hou Hongwei Zhao | 2017 | International Journal of Digital Earth2017，10，9： | 2 |
| 7 | Comparative proteomics analyses of intraspecific differences in the response of Stipa purpurea to drought显示文摘Stipa purpurea is widely distributed along a large precipitation gradient on the Tibetan Plateau.This implies that S.purpurea from different populations may have different responses to drought stress.To explore this we compared the morphological and physiological changes of S.purpurea seedlings cultivated from seeds from Gar County and Nagqu County after 7 and 14 days of drought stress and subsequent rewatering.The results showed that S.purpurea plants from the more arid Gar area were more tolerant to drought stress than that from Nagqu.To investigate the potential mechanisms underlying this difference,we used i TRAQ quantitative proteomics technology to analyze protein dynamics in S.purpurea samples treated with 7 days of drought stress and subsequent re-watering.The results indicated that,during the process of drought and re-watering treatments,there were differentially expressed proteins in either or both S.purpurea populations.These differential proteins were divided into 24 functional categories that were mainly associated with stress response,the antioxidant system,photosynthesis,carbohydrate metabolism,and post-translational modifications.According to these results,we concluded that the molecular basis of stronger drought resistance likely lies in the specific up-regulation or higher expression of many proteins involved in stress response,the antioxidant system,post-translational modification and osmotic regulation in S.purpurea from Gar County compared with that from Nagqu.This study improves our understanding of the intraspecific differences in drought resistance within S.purpurea populations,which helps to understand the distribution of S.purpurea along the moisture gradient,as well as the effect of climate change on this species. | Xiong Li Yunqiang Yang Shihai Yang Xudong Sun Xin Yin Youjie Zhao Yongping Yang | 2016 | 植物分类与资源学报2016，38，2： | 2 |
| 8 | Estimating Fraction of Photosynthetically Active Radiation of Corn with Vegetation Indices and Neural Network from Hyperspectral Data显示文摘The fraction of photosynthetically active radiation(FPAR) is a key variable in the assessment of vegetation productivity and land ecosystem carbon cycles.Based on ground-measured corn hyperspectral reflectance and FPAR data over Northeast China,the correlations between corn-canopy FPAR and hyperspectral reflectance were analyzed,and the FPAR estimation performances using vegetation index(VI) and neural network(NN) methods with different two-band-combination hyperspectral reflectance were investigated.The results indicated that the corncanopy FPAR retained almost a constant value in an entire day.The negative correlations between FPAR and visible and shortwave infrared reflectance(SWIR) bands are stronger than the positive correlations between FPAR and near-infrared band reflectance(NIR).For the six VIs,the normalized difference vegetation index(NDVI) and simple ratio(SR) performed best for estimating corn FPAR(the maximum R2 of 0.8849 and 0.8852,respectively).However,the NN method esti-mated results(the maximum R2 is 0.9417) were obviously better than all of the VIs.For NN method,the two-band combinations showing the best corn FPAR estimation performances were from the NIR and visible bands;for VIs,however,they were from the SWIR and NIR bands.As for both the methods,the SWIR band performed exceptionally well for corn FPAR estimation.This may be attributable to the fact that the reflectance of the SWIR band were strongly controlled by leaf water content,which is a key component of corn photosynthesis and greatly affects the absorption of photosynthetically active radiation(APAR),and makes further impact on corn-canopy FPAR. | YANG Fei ZHU Yunqiang ZHANG Jiahua YAO Zuofang | 2012 | Chinese Geographical Science2012，22，1： | 2 |
| 9 | A new mutant transcript generated in Znf230 exon 2 knockout mice reveals a potential exon structure in the targeting vector sequence显示文摘睾丸基因 Znf230 可以根据以前的报告在哺乳动物的精子发生起一个作用。删除 5 重要 exons 堵住蛋白质的形成是在基因大美人实验的一个平淡的方法。调查 Znf230 基因的生理的功能,有破坏 exon 的变异的老鼠 2 Znf230 在这研究被产生。结果显示出那,变异的 Znf230 鼠标是肥沃、显示出的正常身体,泌尿生殖器的机关,睾丸重量,和 spermatid 数字,但是后代的崽尺寸与不清楚的原因减少了。Hematoxylin 并且曙红染色证明变异的老鼠的阴囊的织物是未经触动的。反向的 transcriptase 聚合酶链反应分析证明二个新奇变异的抄本出现在变异的老鼠:短一包括 exon-1 和 exon-3 到 -6, 出人意料地从充当新 exon 的 pPNT 向量包含一个部分序列的长的 2。长抄本的生物信息的分析表明它可能与一样编码 24-kDa N 终端变异的蛋白质是的 182 氨基酸在 C 终点的野类型的 Znf230,显示 C3HC4 类型戒指手指的潜在的功能的区域在变异的蛋白质是未经触动的。西方的污点和 immunohistochemistry 分析也暗示 Znf230 的这个 N 终端变化可能不破坏野类型的 Znf230 在精子发生起了的可能的作用。在摘要,在指向的向量顺序的潜在的 exon 结构在指向 Znf230 基因的表示包含了并且扰乱了这个指向基因的实验的策略。 | Yunqiang Liu Dachang Tao Sunkai Ma Ying Kuang Dan SU Hao Zhang Yuan Yang Yongxin Ma Sizhong Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 1 |
| 10 | Development and implementation of a real-time see-through-wall radar system based on FPGA显示文摘 | Yang Yunqiang Fathy A E | 2009 | IEEE Transactions on Geoscience and Remote Sensing2009，47，5： | 1 |
| 11 | Speciation analysis of selenium in rice samples by using capillary electrophoresis-inductively coupled plasma mass spectrometry显示文摘 | Yunqiang Zhao Jinping Zheng Mingwei Yang | 2011 | Talanta2011，84，： | 1 |
| 12 | Operculum of a Water Snail is a Hydrodynamic Lubrication Sheet显示文摘 | Xiaoyan Xu Jianing Wu Yunqiang Yang Rengao Zhu Shaoze Yan | 2018 | Journal of Bionic Engineering2018，15，3： | 1 |
| 13 | Development of an Ultra Wideband Vivaldi Antenna Array显示文摘 | Yang Yunqiang Zhang Cemin Lin Song | 2005 | IEEE Antennas and Propagation Society International Symposium2005，1，7： | 1 |
| 14 | Time-resolved measurements of electron number density and collision frequency for fluorescent lamp plasma using microwave diagnostics显示文摘 | Howlader M K Yang Yunqiang Roth J R | 2005 | IEEE Trans on Plasma Science2005，33，3： | 1 |
| 15 | Speciation analysis of selenium in rice samples by using capillary electrophoresis-inductively coupled plasma mass spectrometry显示文摘 | YunQiang Zhao JinPing Zheng MingWei Yang GuiDi Yang YongNing Wu FengFu Fu | 2011 | Talanta2011，，3： | 1 |
| 16 | Development and imple- mentation of a real lime see-through-wall radar system based on FPGA显示文摘 | Yang Yunqiang Falhy A E | 2009 | IEEE Transactions on Geoscienee and Remote Sensing2009，47，5： | 1 |
| 17 | Simultaneous enhancement of strength and ductility in friction stir processed 2205 duplex stainless steel with a bimodal structure:experiments and crystal plasticity modeling显示文摘Achieving excellent strength-ductility synergy is a long-lasting research theme for structural materials.However,attempts to enhance strength usually induce a loss of ductility,i.e.,the strength-ductility trade-off.In the present study,the strength-ductility trade-off in duplex stainless steel(DSS)was overcome by developing a bimodal structure using friction stir processing(FSP).The ultimate tensile strength and elongation were improved by 140%and 109%,respectively,compared with those of the asreceived materials.Plastic deformation and concurrent dynamic recrystallization(DRX)during FSP were responsible for the formation of bimodal structure.Incompatible deformation resulted in the accumulation of dislocations at the phase boundaries,which triggered interpenetrating nucleation between the austenite and ferrite phases during DRX,leading to a bimodal structure.The in situ mechanical responses of the bimodal structure during tensile deformation were investigated by crystal plasticity finite element modeling(CPFEM).The stress field distribution obtained from CPFEM revealed that the simultaneous enhancement of strength and ductility in a bimodal structure could be attributed to the formation of a unique dispersion-strengthened system with the austenite and ferrite phases.It is indicated that the present design of alternating fine austenite and coarse ferrite layers is a promising strategy for optimizing the mechanical properties of DSSs. | Yanying Hu Zexin Fang Yongbing Peng Weiqi Yang Xianfeng Ma Jinglong Li Yunqiang Zhao Biao Wang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 0 |
| 18 | Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation显示文摘During the pathogenesis of type 1 diabetes(T1D) and type 2 diabetes(T2D), pancreatic islets, especially the β cells, face significant challenges. These insulin-producing cells adopt a regeneration strategy to compensate for the shortage of insulin, but the exact mechanism needs to be defined. High-fat diet(HFD) and streptozotocin(STZ) treatment are well-established models to study islet damage in T2D and T1D respectively. Therefore, we applied these two diabetic mouse models, triggered at different ages, to pursue the cell fate transition of isletβ cells. Cre-LoxP systems were used to generate islet cell type-specific(α, β, or δ) green fluorescent protein(GFP)-labeled mice for genetic lineage tracing, thereinto β-cell GFP-labeled mice were tamoxifen induced. Single-cell RNA sequencing(scRNA-seq) was used to investigate the evolutionary trajectories and molecular mechanisms of the GFP-labeled β cells in STZ-treated mice. STZ-induced diabetes caused extensive dedifferentiation of β cells and some of which transdifferentiated into α or δ cells in both youth-and adulthood-initiated mice while this phenomenon was barely observed in HFD models. β cells in HFD mice were expanded via self-replication rather than via transdifferentiation from α or δ cells, in contrast, α or δ cells were induced to transdifferentiate into β cells in STZ-treated mice(both youthand adulthood-initiated). In addition to the re-dedifferentiation of β cells, it is also highly likely that these “α or δ” cells transdifferentiated from pre-existing β cells could also re-trans-differentiate into insulin-producing β cells and be beneficial to islet recovery. The analysis of ScRNA-seq revealed that several pathways including mitochondrial function, chromatin modification, and remodeling are crucial in the dynamic transition of β cells. Our findings shed light on how islet β cells overcome the deficit of insulin and the molecular mechanism of islet recovery in T1D and T2D pathogenesis. | Qi Fu Yu Qian Hemin Jiang Yunqiang He Hao Dai Yang Chen Zhiqing Xia Yucheng Liang Yuncai Zhou Rui Gao Shuai Zheng Hui Lv Min Sun Kuanfeng Xu Tao Yang | 2024 | Science China(Life Sciences)2024，67，3： | 0 |
| 19 | Differences in pseudogene evolution contributed to the contrasting flavors of turnip and Chiifu, two Brassica rapa subspecies显示文摘Pseudogenes are important resources for investigation of genome evolution and genomic diversity because they are nonfunctional but have regulatory effects that influence plant adaptation and diversification.However,few systematic comparative analyses of pseudogenes in closely related species have been conducted.Here,we present a turnip(Brassica rapa ssp.rapa)genome sequence and characterize pseudogenes among diploid Brassica species/subspecies.The results revealed that the number of pseudogenes was greatest in Brassica oleracea(CC genome),followed by B.rapa(AA genome)and then Brassica nigra(BB genome),implying that pseudogene differences emerged after species differentiation.In Brassica AA genomes,pseudogenes were distributed asymmetrically on chromosomes because of numerous chromosomal insertions/rearrangements,which contributed to the diversity among subspecies.Pseudogene differences among subspecies were reflected in the flavor-related glucosinolate(GSL)pathway.Specifically,turnip had the highest content of pungent substances,probably because of expansion of the methylthioalkylmalate synthase-encoding gene family in turnips;these genes were converted into pseudogenes in B.rapa ssp.pekinensis(Chiifu).RNA interference-based silencing of the gene encoding 2-oxoglutarate-dependent dioxygenase 2,which is also associated with flavor and anticancer substances in the GSL pathway,resulted in increased abundance of anticancer compounds and decreased pungency of turnip and Chiifu.These findings revealed that pseudogene differences between turnip and Chiifu influenced the evolution of flavor-associated GSL metabolism-related genes,ultimately resulting in the different flavors of turnip and Chiifu. | Xin Yin Danni Yang Youjie Zhao Xingyu Yang Zhili Zhou Xudong Sun Xiangxiang Kong Xiong Li Guangyan Wang Yuanwen Duan Yunqiang Yang Yongping Yang | 2023 | Plant Communications2023，4，1： | 0 |
| 20 | Effects of Nectar Property on Compensated Dipping Behavior of Honey Bees with Damaged Tongues显示文摘In nature,bees with damaged tongues are adapted to have a feat in collecting nectariferous sources in a large spectrum of concentrations(19%-69%)or viscosities(10^(-3)Pa·s to 10^(-1)Pa·s);however,eff ects of nectar property on compensated dipping behavior remain elusive.Combining the bee tongue anatomy,high-speed videography,and mathematical models,we investigate responses of honey bees with damaged tongues to fluidic sources in various properties.We find that,bees with 80%damaged tongues are deprived of feeding capability and remarkably,the dipping frequency increases from 4.24 Hz to 5.08 Hz while ingesting 25%sugar water when the tongue loses 0-30%in length,while declines from 5.08 to 3.86 Hz in case of 30%damaged tongue when sucrose concentration increases from 25%to 45%.We employ the energetic compensation rate and energetic utilization rate to evaluate eff ectiveness of the compensation from the perspective of energetic regulation.The mathematical model indicates that the energetic compensation rate turns higher in bees with less damaged tongues for ingesting dilute sugar water,demonstrating its capability of functional compensation for combined factors.Also,the tongue-damaged bees achieve the highest energetic utilization rate when ingesting~30%sugar water.Beyond biology,the findings may shed lights on biomimetic materials and technologies that aim to compensate for geometrical degradations without regeneration. | Jingrui Wang Yu Sun Wei Zhang Yunqiang Yang Shaoze Yan Jianing Wu | 2021 | Journal of Bionic Engineering2021，18，5： | 0 |
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