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| 1 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Essential oils extraction from Anoectochilus roxburghii using supercritical c,xrbon dioxide and their antioxidant activity显示文摘 | QINGSONG SHAO YANMING DENG HONGBO LIU | 2014 | Industrial Crops and Products2014，，60： | 1 |
| 3 | The chromosome-level genome of double-petal phenotype jasmine provides insights into the biosynthesis of floral scent显示文摘Jasmine(Jasminum sambac Aiton)is a well-known cultivated plant species for its fragrant flowers used in the perfume industry and cosmetics.However,the genetic basis of its floral scent is largely unknown.In this study,using PacBio,Illumina,10×Genomics and highthroughput chromosome conformation capture(Hi-C)sequencing technologies,a high-quality chromosome-level reference genome for J.sambac was obtained,exploiting a double-petal phenotype cultivar‘Shuangbanmoli’(JSSB).The results showed that the final assembled genome of JSSB is 580.33 Mb in size(contig N50=1.05 Mb;scaffold N50=45.07 Mb)with a total of 39618 predicted protein-coding genes.Our analyses revealed that the JSSB genome has undergone an ancient whole-genome duplication(WGD)event at 91.68 million years ago(Mya).It was estimated that J.sambac diverged from the lineage leading to Olea europaea and Osmanthus fragrans about 28.8 Mya.On the basis of a combination of genomic,transcriptomic and metabolomic analyses,a range of floral scent volatiles and genes were identified involved in the benzenoid/phenylpropanoid and terpenoid biosynthesis pathways.The results provide new insights into the molecular mechanism of its fragrance biosynthesis in jasmine. | Xiangyu Qi Huadi Wang Shuyun Liu Shuangshuang Chen Jing Feng Huijie Chen Ziyi Qin Quanming Chen Ikram Blilou Yanming Deng | 2024 | Horticultural Plant Journal2024，10，1： | 1 |
| 4 | Interspecific hybrids between Dendranthema morifolium (Ramat.) Kitamura and D. nankingense (Nakai) Tzvel. achieved using ovary rescue and their cold tolerance characteristics显示文摘 | Xi Cheng Sumei Chen Fadi Chen Weimin Fang Yanming Deng Linfang She | 2010 | Euphytica2010，，1： | 1 |
| 5 | Production and characterisation of the intergeneric hybrids between Dendranthema morifolium and Artemisia vulgaris exhibiting enhanced resistance to chrysanthemum aphid (Macrosiphoniella sanbourni)显示文摘 | Yanming Deng Sumei Chen Aimin Lu Fadi Chen Fangping Tang Zhiyong Guan Nianjun Teng | 2010 | Planta2010，，3： | 1 |
| 6 | Solar-driven high-temperature steam generation at ambient pressure显示文摘This paper demonstrates a facile solar steam generator for the generation of high-temperature steam at ambient pressure. The steam generator consists of a coiled copper tube(CCT) that serves as both solar collector and vapor heater. Both the inner and outer surfaces of the CCT are coated with black superhydrophobic copper oxide layer to improve the solar absorption, and such superhydrophobic layer prevents the condensation and clogging of water vapor during the heating process. Solar vapor is generated at the inlet of CCT through interfacial evaporation and subsequently heated inside the CCT as the vapor travels from the inlet to the outlet. By employing this approach, steam temperature that exceeds 100℃ under 1-sun illumination is demonstrated. Furthermore,steam temperature could reach as high as 250℃ under 10-sun illumination at ambient pressure. Successful sterilization experiment was also performed in this work to demonstrate the potential application of the high temperature steam generated. Such demonstrated approach helps open up the potential usage of solar-driven interfacial evaporation in applications that involve high-temperature steam, including medical sterilization,chemical manufacturing and food processing. | Xinyu Wang Yanming Liu Rui Feng Yao Zhang Chao Chang Benwei Fu Tian Luan Peng Tao Wen Shang Jianbo Wu Chengyi Song Tao Deng | 2019 | Progress in Natural Science:Materials International2019，29，1： | 0 |
| 7 | Circuit-Specific Control of Blood Pressure by PNMT‑Expressing Nucleus Tractus Solitarii Neurons显示文摘The nucleus tractus solitarii(NTS)is one of the morphologically and functionally defined centers that engage in the autonomic regulation of cardiovascular activity.Phenotypically-characterized NTS neurons have been implicated in the differential regulation of blood pressure(BP).Here,we investigated whether phenylethanolamine N-methyltransferase(PNMT)-expressing NTS(NTS^(PNMT))neurons contribute to the control of BP.We demonstrate that photostimulation of NTS^(PNMT)neurons has variable effects on BP.A depressor response was produced during optogenetic stimulation of NTS^(PNMT)neurons projecting to the paraventricular nucleus of the hypothalamus,lateral parabrachial nucleus,and caudal ventrolateral medulla.Conversely,photostimulation of NTS^(PNMT)neurons projecting to the rostral ventrolateral medulla produced a robust pressor response and bradycardia.In addition,genetic ablation of both NTS^(PNMT)neurons and those projecting to the rostral ventrolateral medulla impaired the arterial baroreflex.Overall,we revealed the neuronal phenotype-and circuit-specific mechanisms underlying the contribution of NTS^(PNMT)neurons to the regulation of BP. | Shirui Jun Xianhong Ou Luo Shi Hongxiao Yu Tianjiao Deng Jinting Chen Xiaojun Nie Yinchao Hao Yishuo Shi Wei Liu Yanming Tian Sheng Wang Fang Yuan | 2023 | Neuroscience Bulletin2023，39，8： | 0 |
| 8 | Proton‑Prompted Ligand Exchange to Achieve High‑Efficiency CsPbI_(3)Quantum Dot Light‑Emitting Diodes显示文摘CsPbI_(3)perovskite quantum dots(QDs)are ideal materials for the next generation of red light-emitting diodes.However,the low phase stability of CsPbI_(3)QDs and long-chain insulating capping ligands hinder the improvement of device performance.Traditional in-situ ligand replacement and ligand exchange after synthesis were often difficult to control.Here,we proposed a new ligand exchange strategy using a proton-prompted insitu exchange of short 5-aminopentanoic acid ligands with long-chain oleic acid and oleylamine ligands to obtain stable small-size CsPbI_(3)QDs.This exchange strategy maintained the size and morphology of CsPbI_(3)QDs and improved the optical properties and the conductivity of CsPbI_(3)QDs films.As a result,high-efficiency red QD-based light-emitting diodes with an emission wavelength of 645 nm demonstrated a record maximum external quantum efficiency of 24.45%and an operational half-life of 10.79 h. | Yanming Li Ming Deng Xuanyu Zhang Lei Qian Chaoyu Xiang | 2024 | Nano-Micro Letters2024，16，6： | 0 |
| 9 | Transpiration Rates of Carex Meyeriana in Relation to Micrometerological Factors in a Mountain Valley Wetland显示文摘In order to reveal transpiration rates of wetland plants and its relationships to micro-meterological factors in a mountain valley wetland, relative humidity, air temperature, leaf temperature, soil temperature, photo flux density and transpiration rates were measured once two hours in a Carex meyeriana wetland of the Changbai Mountain valley in dry (July) and wet (September) of 2003, respectively. Results showed that the tendency of 'decreasing after increasing' was obvious in wet season. However, a relatively stable trend was observed for the transpiration in dry season.. Generally, the photon flux density of Carex meyeriana was higher in wet season than that in dry season. However, the variabilities of leaf temperature, air temperature and relative humidity were similar in both seasons. Higher transpiration rates of Carex meyeriana leaves were observed in July (varied from 40 to 150 mol·m-2·s-1) compared to those (varied from 7 to 14 mol·m-2·s-1) in September. Transpiration rates were significantly correlated with air temperature (P<0.01), leaf temperature (P<0.01), and wind speed (P<0.05), but correlationship between relative humidity and photo flux density was not significant (P<0.05). | XU Huifeng JIN Yanming DENG Wei XU Kezhang WANG Zhen | 2009 | Journal of Mountain Science2009，6，3： | 0 |
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