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| 1 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Precise base editing of non-allelic acetolactate synthase genes confers sulfonylurea herbicide resistance in maize显示文摘Single-nucleotide polymorphisms contribute to phenotypic diversity in maize. Creation and functional annotation of point mutations has been limited by the low efficiency of conventional methods based on random mutation. An efficient tool for generating targeted single-base mutations is desirable for both functional genomics and precise genetic improvement. The objective of this study was to test the efficiency of targeted C-to-T base editing of two non-allelic acetolactate synthase(ALS) in generating sulfonylurea herbicide-resistant mutants. A CRISPR/Cas9 nickase-cytidine deaminase fused with uracil DNA glycosylase inhibitor(UGI) was employed to achieve targeted conversion of cytosine to thymine in ZmALS1 and ZmALS2. Both protoplasts and recovered mutant plants showed the activity of the cytosine base editor, with an in vivo efficiency of up to 13.8%. Transgene-free edited plants harboring a homozygous ZmALS1 mutation or a ZmALS1 and ZmALS2 double mutation were tested for their resistance at a dose of up to 15-fold the recommended limit of chlorsulfuron, a sulfonylurea herbicide widely used in agriculture. Targeted base editing of C-to-T per se and a phenotype verified in the generated mutants demonstrates the power of base editing in precise maize breeding. | Yanmin Li Jinjie Zhu Hao Wu Changlin Liu Changling Huang Jinhao Lan Yanming Zhao Chuanxiao Xie | 2020 | The Crop Journal2020，8，3： | 9 |
| 3 | Invited review:Remediation strategies for mycotoxin control in feed显示文摘Mycotoxins are secondary metabolites of different species of fungi.Aflatoxin B1(AFB1),deoxynivalenol(DON),zearalenone(ZEN)and fumonisin B1(FB1)are the main mycotoxins contaminating animal feedstuffs.These mycotoxins can primarily induce hepatotoxicity,immunotoxicity,neurotoxicity and nephrotoxicity,consequently cause adverse effects on the health and performance of animals.Therefore,physical,chemical,biological and nutritional regulation approaches have been developed as primary strategies for the decontamination and detoxification of these mycotoxins in the feed industry.Meanwhile,each of these techniques has its drawbacks,including inefficient,costly,or impractically applied on large scale.This review summarized the advantages and disadvantages of the different remediation strategies,as well as updates of the research progress of these strategies for AFB1,DON,ZEN and FB1 control in the feed industry. | Meng Liu Ling Zhao Guoxin Gong Lei Zhang Lei Shi Jiefan Dai Yanming Han Yuanyuan Wu Mahmoud Mohamed Khalil Lvhui Sun | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 8 |
| 4 | TSdb:A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates显示文摘TSdb (http://tsdb.cbi.pku.edu.cn) is the first manually curated central repository that stores formatted information on the substrates of transporters. In total, 37608 transporters with 15075 substrates from 884 organisms were curated from UniProt functional annotation. A unique feature of TSdb is that all the substrates are mapped to identifiers from the KEGG Ligand com- pound database. Thus, TSdb links current metabolic pathway schema with compound transporter systems via the shared compounds in the pathways. Furthermore, all the transporter substrates in TSdb are classified according to their biochemical properties, biological roles and subcellular localizations. In addition to the functional annotation of transporters, extensive compound annotation that includes inhibitor information from the KEGG Ligand and BRENDA databases has been integrated, making TSdb a useful source for the discovery of potential inhibitory mechanisms linking transporter substrates and metabolic enzymes. User-friendly web interfaces are designed for easy access, query and download of the data. Text and BLAST searches against all transporters in the database are provided. We will regularly update the substrate data with evidence from new publications. | ZHAO Min CHEN YanMing QU DaCheng QU Hong | 2011 | Science China(Life Sciences)2011，54，1： | 6 |
| 5 | cDNA cloning and expression of erythropoietin in the plateau zokor(Myospalax baileyi) from the Qinghai-Tibet Plateau显示文摘All organisms respond to variation in their environments and manage environmental stress through metabolic adjustments.The plateau zokor(Myospalax baileyi) is an endemic and keystone subterranean rodent species that inhabits the Qinghai-Tibet Plateau between 2800 and 4200 m above sea level.It is a hypoxic-tolerant mammal with a high ratio of oxygen utilization that enables it to cope with its harsh surroundings.To explore the molecular mechanism of altitude acclimatization of the plateau zokor,we cloned the zokor erythropoietin(Epo) gene and used real-time PCR to compare Epo mRNA levels in zokors inhabiting 16 different altitudes.The full-length zokor Epo open reading frame was 579 bp that encoded a precursor peptide of 192 amino acids with a signal peptide of 26 residues.The Epo gene of the plateau zokor was 81%-95% homologous to that of human,mouse,rat,root vole and the Golan Heights blind mole rat,with the highest homology(95%) to species of the genus Spalax.Epo mRNA was detected mainly in the zokor kidney and spleen among 8 selected tissues.The level of Epo mRNA increased in the liver and kidney with increases in altitude.The increase in the kidney was 5 times that in the liver.Remarkably,expression of Epo mRNA in the kidney of zokors living at the highest altitude(4268 m) was 12-fold higher than that of zokors living at the lowest(2492 m) altitude.These findings provide essential information for understanding the possible role of Epo in adaptation to hypoxia in the plateau zokor. | WANG ZhenLong CHEN Yan YANG Jie CHEN WeiJun ZHANG YanMing ZHAO XinQuan | 2012 | Chinese Science Bulletin2012，57，9： | 4 |
| 6 | Feasibility study on application of volume acid fracturing technology to tight gas carbonate reservoir development显示文摘How to effectively develop tight-gas carbonate reservoir and achieve high recovery is always a problem for the oil and gas industry.To solve this problem,domestic petroleum engineers use the combination of the successful experiences of North American shale gas pools development by stimulated reservoir volume(SRV)fracturing with the research achievements of Chinese tight gas development by acid fracturing to propose volume acid fracturing technology for fractured tightgas carbonate reservoir,which has achieved a good stimulation effect in the pilot tests.To determine what reservoir conditions are suitable to carry out volume acid fracturing,this paper firstly introduces volume acid fracturing technology by giving the stimulation mechanism and technical ideas,and initially analyzes the feasibility by the comparison of reservoir characteristics of shale gas with tight-gas carbonate.Then,this paper analyzes the validity and limitation of the volume acid fracturing technology via the analyses of control conditions for volume acid fracturing in reservoir fracturing performance,natural fracture,horizontal principal stress difference,orientation of insitu stress and natural fracture,and gives the solution for the limitation.The study results show that the volume acid fracturing process can be used to greatly improve the flow environment of tight-gas carbonate reservoir and increase production;the incremental or stimulation response is closely related with reservoir fracturing performance,the degree of development of natural fracture,the small intersection angle between hydraulic fracture and natural fracture,the large horizontal principal stress difference is easy to form a narrow fracture zone,and it is disadvantageous to create fracture network,but the degradable fiber diversion technology may largely weaken the disadvantage.The practices indicate that the application of volume acid fracturing process to the tight-gas carbonate reservoir development is feasible in the Ordovician Majiagou Formation of lower Paleozoic,which is of great significance and practical value for domestic tight-gas carbonate reservoir development and studies in the future. | Nianyin Li Jinxin Dai Chao Liu Pingli Liu Yanming Zhang Zhifeng Luo Liqiang Zhao | 2015 | Petroleum2015，1，3： | 4 |
| 7 | CRISPRs provide broad and robust protection to oral microbial flora of gingival health against bacteriophage challenge显示文摘 | Huiyue Zhou (1) (2) Hui Zhao (3) Jiayong Zheng (3) Yuan Gao (1) (2) Yanming Zhang (1) Fangqing Zhao (1) Jinfeng Wang (1) | 2015 | Protein & Cell2015，6，7： | 2 |
| 8 | Corrosion behavior of Q235B carbon steel in simulated seawater pumped storage system under operational conditions显示文摘Seawater pumped storage systems have bright prospect for energy storage in the coming years.The operational conditions of seawater pumped storage system are complex and harsh,where metal materials suff er from severe general and local corrosion.The corrosion behavior of Q235B carbon steel in simulated seawater pumped storage system under operational conditions was studied by potentiodynamic polarization,cyclic potentiodynamic polarization,and scanning electron microscope(SEM).The results confi rm that the working pressure aff ected the corrosion resistance of Q235B carbon steel during the whole immersion period.The pressure promoted the electrochemical reaction of corrosion process and the corrosion rate increased with pressure at the initial immersion period.However,the stable rust layer formed after longtime immersion at diff erent pressures increased the corrosion resistance of carbon steel,and decreased the corrosion degree of carbon steel.Meanwhile,the working pressure aff ected the pitting corrosion behavior of Q235B carbon steel during the whole immersion period.The pitting corrosion potential was more negative and the tendency of pitting corrosion was higher at 4 MPa during the whole immersion period.However,pressure also accelerated the formation rate of protective rust layer on the steel surface.Q235B carbon steel has higher susceptibility to pitting corrosion at 4 MPa in the static seawater. | YANG Dan HUANG Yanliang LI Jianqiu GAO Yanming ZHAO Xia XU Weichen | 2020 | Journal of Oceanology and Limnology2020，38，5： | 2 |
| 9 | High - performance all - optical OR/NOR logic gate in a single semiconductor optical amplifier with delay interference filtering显示文摘 | Yanming Feng Xiaofan Zhao Li Wang Caiyun Lou | 2009 | Applied Optics2009，48，14： | 1 |
| 10 | 显示文摘 | Zhao Yanming Liang Jingkui Rao Guanghui | 1997 | J Phys Condens Matter1997，9，： | 1 |
| 11 | 显示文摘 | Zhao Yanming Liang Jingkui Tang Weihua | 1995 | J Appl Phys1995，78，4： | 1 |
| 12 | Oil field wastewater treatment in biological aerated filter by immobilized microorganisms 显示文摘 | Zhao Xin Wang Yanming Ye Zhengfang | 2006 | Process Biochem2006，41，7： | 1 |
| 13 | Studies on glass transition temperature of ehitosan with four techniques 显示文摘 | Dong Yanming Ruan Yonghong Wang Huiwu Zhao Yaging Bi Danxia | 2004 | Journal of Applied Polymer Science2004，93，15： | 1 |
| 14 | Development of a symmetrical spiral inlet to improve cyclone separator performance显示文摘 | ZHAO Bingtao SHEN Henggen KANG Yanming | 2004 | Powder Technology2004，145，1： | 1 |
| 15 | Oil field wastewater treatment in biological aerated filter by immobi lized microorganisms显示文摘 | ZHAO Xin WANG Yanming YE Zhengfang | 2006 | Process Biochemistry2006，41，： | 1 |
| 16 | Partial discharge characteristics and mechanism in voids at impulse voltages显示文摘 | ZHAO Xuefeng GUO Zhifeng LI Yanming | 2011 | Measurement Science & Technology2011，22，3： | 1 |
| 17 | Vindesine induces rhabdomyolysis in patients with acute lymphoblastic leukemia显示文摘Rhabdomyolysis is a syndrome which involves myoglobin and other intracellular proteins and electrolytes that occurs from breakdown of skeletal muscleand leak into the circulation.1 The clinical symptoms of rhabdomyolysis include myalgia,tenderness on palpation,weakness,brown urine,fever,myoglobinuria,electrolyte imbalance,and acute renal failure.Rhabdomyolysis can be severe enough to be life threatening.2 The causes of rhabdomyolysis include alcohol,electrolyte imbalance (potassium,phosphorus,and magnesium depletion),viral myositis,trauma,connective tissue diseases,drug reaction,toxication,exercise,metabolic diseases,seizures,and hereditary enzyme deficiencies.The exact mechanisms underlying rhabdomyolysis are not fully understood,but it is clear that muscle damage can be caused by direct muscle injury or metabolic inequalities between energy production and energy consumption. | Liu Limin Sun Yumei Si Yejun Lin Guoqiang Zhang Xingxia Zhao Guangsheng Zhang Yanming Wu Depei | 2014 | Chinese Medical Journal2014，，21： | 1 |
| 18 | Spontaneous magne-tostriction of the HeDy2AIFe8Mn8compound显示文摘 | HAO Yanming ZHOU Yan ZHAO Miao | 2007 | Phys Scr2007，129，： | 1 |
| 19 | Oil field wastewater treatment in biological aerated filter by immobilized microorganisms显示文摘 | Zhao Xin Wang Yanming Ye Zhengfang | 2006 | Process Biochemistry2006，41，7： | 1 |
| 20 | Negative thermal expansion and spontaneous volumemagnetostriction of Tb2Fe16Cr compound显示文摘 | HAO Yanming ZHOU Miao ZHAO Yan | 2005 | Scr Mater2005，53，： | 1 |
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