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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | One-passwavelet decompositions of data streams显示文摘 | Anna C G Yannis K Muthukrishnan S | 2003 | IEEE Transactions on Knowledge and Data Engineering2003，15，3： | 1 |
| 3 | Synthesis and application of some 1 - alkylidene -substituted heteroeycles as bactericides, funjicides, and bioregulator 显示文摘 | KHALIL Z H YANNI A S KHALAF A A | 1988 | J Bull Chem Soc Jpn1988，62，： | 1 |
| 4 | Reduced synovial mem- brane macrophage numbers, ELAM-1 expression, and lining layer hyperplasia in psoriatic arthritis as compared with rheu- matoid arthritis显示文摘 | Veale D Yanni G Rogers S | 1993 | Arthritis Rheum1993，36，： | 1 |
| 5 | Fast and Accurate Link Prediction in Social Network Systems显示文摘 | Alexis P Panagiotis S Yannis M | 2012 | The Journal of Systems and Software2012，85，： | 1 |
| 6 | Research joint ventures显示文摘 | Yannis Caloghirou Stavros Ioannides Nicholas S Vonortas | 2003 | Journal of Economic surveys2003，17，4： | 1 |
| 7 | Video-Assisted Thoracoscopic sur- gery combined with a tubular retractor system for minimally invasive thoracic discectomy 显示文摘 | Daniel S Yanni CC Noel I | 2011 | Neurosurgery2011，68，3： | 1 |
| 8 | Endogenous avidin-binding activity in epithelial cells of the ducts of human salivary glands显示文摘 | Cauli A Yanni G Panayi G S | 1994 | Clin Exp Rheumatol1994，12，： | 1 |
| 9 | Plant lignin and nitrogen contents control carbon dioxide production and nitrogen mineralization from soils incubated with Bt and non-Bt corn residues显示文摘 | YANNI S | 2004 | Journal of Food Science&Nutrition2004，9，： | 1 |
| 10 | Synthesis an application of some 1- alky- lidene-substituted heterocycles as bactericides, fungicides and bio regulators显示文摘 | Khalil Z H Yanni A S Khalaf A A | 1988 | Bull Chem Soc Japan1988，62，4： | 1 |
| 11 | Synthesis of New Anifdo-Pyrazoline and Isoxazoline Derivatives显示文摘 | Khali H Z Yanni S A | 1981 | J Indian Chem Soc1981，58，： | 1 |
| 12 | Gravel Vertical Mulching for Improving water use efficiency of drip irrigated orchards显示文摘 | Yanni S Nimah M N Bashour I | 2004 | Acta Hort ISHS2004，664，： | 1 |
| 13 | Molecular interactions in crystallizing lysozyme solutions studied by photon correlation spectroscopy显示文摘 | Wolfram E Yannis G Wolfram S | 1994 | Journal of crystal growth1994，143，： | 1 |
| 14 | Disposition and interaction of biotherapeutics in pediatric populations显示文摘 | Yanni S | | 0，，07： | 1 |
| 15 | Spectrophotometric determination of trace amounts of vanadium based on its catalytic effect on the reaction of diphenylamine and hydrogen peroxide显示文摘 | THEODOSIOS S S YANNIS M A MAMAS I P | 2000 | Mikrochim Acta2000，135，3： | 1 |
| 16 | Evaluation of multicast muting algorithms for real-time communication on high-speed networks显示文摘 | Hussein F Salama Douglas S Reeves Yannis Viniotis | 1997 | IEEE Journal on Selected Areas in Communication1997，15，3： | 1 |
| 17 | Different distrib- ution patterns of cerebral microbleeds in acute ischemic stroke pationts with and without hypertension 显示文摘 | Jian S Yannie Y S Wynnie W M L | 2009 | Eur Neurology2009，62，： | 1 |
| 18 | Retinal Safety of Near-infrared Lasers in Cataract Surgery显示文摘 | Jenny W Christopher S Yannis M P | 2012 | Journal of Biomedical Optics2012，17，09： | 1 |
| 19 | Gravel vertical mulching for improving water use efficiency of drip irrigated orchards显示文摘 | YANNI S NIMAH M N BASHOUR I | 2004 | Acta Hort ISHS2004，664，： | 1 |
| 20 | University - Industry Cooperation in the Context of the European Framework Programmes显示文摘 | Yannis Caloghirou Aggelos Tsakanikas Nichlos S Vonortas | 2001 | Journal of Technology Transfer2001，，26： | 1 |
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