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| 1 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 2 | A flow method with photocatalytic oxidation of dissolved organic matter using a solid-phase (TiO2) reactor followed by amperometric detection of consumed oxygen显示文摘 | KIM Y C SASAKI S YANO K | 2002 | Analytical Chemistry2002，74，： | 1 |
| 3 | RNA interference of valosin-eontaining protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/ proteasome-dependent proteolysis显示文摘 | Wojcik C Yano M DeMartino GN | 2004 | J Cell Sci2004，117，2： | 1 |
| 4 | Lot sizing with random yields: a review 显示文摘 | Yano C A Lee H L | 1995 | Operations Research1995，43，2： | 1 |
| 5 | GnRH II as a possible cytostatic regulator in the development of endometriosis显示文摘 | Morimoto C Osuga Y Yano T | 2005 | Hum Reprod2005，20，： | 1 |
| 6 | Lot sizing in assembly systems with random component yields 显示文摘 | Gerchak Y Wang Y Z Yano C A | 1994 | IIE Transactions1994，26，2： | 1 |
| 7 | A framework for capacity planning and machine configuration in flexible assembly systems显示文摘 | Lee H F Srinivasan M M Yano C A | 2006 | Int J Flex Manuf Syst2006，18，： | 1 |
| 8 | Angiotensin Ⅱ type 1 and type 2 receptor-induced cell signaling 显示文摘 | Akazawa H Yano M Yabumoto C | 2013 | Curt Pharm Des2013，19，17： | 1 |
| 9 | Surgical management of tuberculum sellae meningioma:role of selective extradural anterior clinoidectomy显示文摘 | Otani N Muroi C Yano H | 2006 | Br J Neurosurg2006，20，3： | 1 |
| 10 | Effects of excision repair cross-complementation group 1(ERCC1)single nucleotide polymorphisms on the prognosis of non-small coll lung cancer patients显示文摘 | Takonaka T Yano T Kiyokara C | 2010 | Lung Cancer2010，67，1： | 1 |
| 11 | A case of fulmi- nant type 1 diabetes with coxsackie IM virus infection diagnosed by elevated serum levels of neutralizing antibody 显示文摘 | AKATSUKA H YANO Y GABAZZA E C | 2009 | Diabetes Res Clin Pract2009，84，： | 1 |
| 12 | The economic lot and delivery scheduling problem:the single item case显示文摘 | HAHM J YANO C A | 1992 | International Journal of Production Economics1992，28，2： | 1 |
| 13 | Calcium-doped MgTiO3-MgTi2O5 ceramics prepared using a reaction-sintering process显示文摘 | LIOU Y C YANO S L | 2007 | Mater Sci Eng B2007，142，23： | 1 |
| 14 | GnRH Ⅱ as a possible cytostatic regulator in the development of endometriosis显示文摘 | Morimoto C Osuga Y Yano T | 2005 | Hum Reprod2005，20，11： | 1 |
| 15 | Mechanism of Macrophage-Derived Chemokine/CCL22 Production by HaCaT Ke- ratinocytes显示文摘 | Yano C Saeki H Komine M | 2015 | J Ann Dermatol2015，27，2： | 1 |
| 16 | Scheduling trains and containers with due dates and dynamic arrivals显示文摘 | Newman A M | 2001 | Transportation Science2001，35，2： | 1 |
| 17 | In- creased plasma thrombin-activatable fibrinolysis in- hibitdr levels in normotensive type 2 diabetic patients with microalbuminuria显示文摘 | YANO Y KITAGAWA N GABAZZA E C | 2003 | J Clin Endocrinol Metab2003，88，： | 1 |
| 18 | Carbon-centeredfree radicals in particulate matter emissions from wood and coalcombustion显示文摘 | TIAN Linwei KOSHLAND C P YANO J | 2009 | Energy & Fuels2009，23，5： | 1 |
| 19 | Survey, development, and application of algorithms for sequencing paced assembly lines 显示文摘 | Yano C A Bolat A | 1989 | Journal of Manufacturing OperationsManagement1989，，2： | 1 |
| 20 | Five decades of operations management and the prospects ahead显示文摘 | Chopra S Lovejoy W Yano C | 2004 | Management Science2004，50，1： | 1 |
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