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| 1 | MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis显示文摘T cell-mediated immunity in the intestine is stringently controlled to ensure proper immunity against pathogenic microbes and to prevent autoimmunity,a known cause of inflammatory bowel disease.However,precisely how T cells regulate intestine immunity remains to be fully understood.In this study,we found that mitogen-activated protein kinase kinase kinase 2(MAP3K2)is required for the CD4^(+)T cell-mediated inflammation in the intestine.Using a T cell transfer colitis model,we found that MAP3K2-deficient naïve CD4^(+)T cells had a dramatically reduced ability to induce colitis compared to wild type T cells.In addition,significantly fewer IFN-γ-but more IL-17A-producing CD4^(+)T cells in the intestines of mice receiving MAP3K2-deficient T cells than in those from mice receiving wild type T cells was observed.Interestingly,under well-defined in vitro differentiation conditions,MAP3K2-deficient naïve T cells were not impaired in their ability to differentiate into Th1,Th17 and Treg.Furthermore,the MAP3K2-regulated colitis severity was mediated by Th1 but not Th17 cells in the intestine.At the molecular level,we showed that MAP3K2-mediated Th1 cell differentiation in the intestine was regulated by IL-18 and required specific JNK activation.Together,our study reveals a novel regulatory role of MAP3K2 in intestinal T cell immunity via the IL-18-MAP3K2-JNK axis and may provide a novel target for intervention in T cell-mediated colitis. | Ningbo Wu Dongping Chen Hongxiang Sun Jianmei Tan Yao Zhang Tianyu Zhang Yuheng Han Hongzhi Liu Xinxing Ouyang Xiao-Dong Yang Xiaoyin Niu Jie Zhong Zhengting Wang Bing Su | 2021 | Science China(Life Sciences)2021，64，3： | 3 |
| 2 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 3 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 4 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 5 | Monitoring and Assessment of Current Situation of Environmental Quality in Yueqing Bay显示文摘Based on the monitoring results of environmental quality in Yueqing Bay during 2007-2014,the current situation of environmental quality in the bay was analyzed and assessed. The results show that pH,DO,CODMn,petroleum,and heavy metals( Cu,Pb,Zn,Cd,Hg,As and Cr)in the seawater of Yueqing Bay did not exceed the second class standard of Seawater Quality Standard( GB 3097-1997),but inorganic nitrogen and reactive phosphate in the seawater of Yueqing Bay exceeded the second class standard seriously,and the water quality of the bay was in an eutrophic state; the standard index of evaluation factors of sediment quality was smaller than 1,meeting the demands of sediment quality for environmental protection. | Yang Dan Zhang Haisheng Xu Hengtao Song Weihua Lin Bo Yao Dongping Ye Xinrong | 2017 | Meteorological and Environmental Research2017，8，2： | 1 |
| 6 | A new transmission scheme for railway based on OFDM-SFN 显示文摘 | GAO Aiqin YAO Dongping | 2007 | IEEE 2007 International Symposium on Microwave Antenna Propagation and EMC Technologies for Wireless Communications2007，44，4： | 1 |
| 7 | Monitoring and Evaluation of Present Situation of Environmental Quality in the Sea Area near the Aojiang Estuary in Wenzou显示文摘Based on the monitoring results of environmental quality in the sea area near the Aojiang estuary in Wenzou during 2010-2012,the present situation of environmental quality in the sea area was analyzed and evaluated. The results show that p H,DO,CODMn,petroleum,and heavy metals( Cu,Pb,Zn,Cd,Hg,As and Cr) in the sea area near the Aojiang estuary did not exceed the second-class standard of Seawater Quality Standard( GB 3097-1997),but both inorganic nitrogen and reactive phosphate in the sea area exceeded the second-class standard seriously,and the water quality of the sea area was in an eutrophic state; domestic sewage and fertilizer loss were the main sources of nitrogen and phosphorus. The standard index of most evaluation factors of sediment quality except for Zn was smaller than 1,meeting the demands of sediment quality for environmental protection. | Ye Maosen Yang Dan Zhang Rongbao Xu Hengtao Zhang Haisheng Yao Dongping Ye Xinrong | 2017 | Meteorological and Environmental Research2017，8，3： | 1 |
| 8 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 9 | Effects of alcohols on shape-tuning and luminescence-enhancing of C 70 nanocrystals显示文摘 | Dedi Liu Wen Cui Mingguang Yao Quanjun Li Tian Cui Bingbing Liu Dongping Liu Bertil Sundqvist | 2013 | Optical Materials2013，，2： | 1 |
| 10 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 11 | Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，： | 1 |
| 12 | Monitoring and Evaluation of Environmental Quality of the Waters near the Feiyun River Estuary in Wenzou in Recent Years显示文摘Based on the monitoring results of environmental quality of the waters near the Feiyun River estuary during 2011-2016, the current situation of environmental quality of the waters was analyzed and evaluated. The results showed that pH, DO, COD Mn , petroleum, and heavy metals (Cu, Pb, Zn, Cd, Hg, As and Cr) in the waters near the Feiyun River estuary did not exceed the second-class standard of Seawater Quality Standard (GB 3097-1997), while both inorganic nitrogen and reactive phosphate in the waters exceeded the second-class standard obviously. The water quality of the waters near the Feiyun River estuary was in an eutrophic state. In terms of sediment quality, the standard index of most evaluation factors except for Cu was smaller than 1, meeting the demands of sediment quality for environmental protection. | Yao Dongping Lin Bo Zhang Haifeng Zheng Fangqin Ye Xinrong | 2019 | Meteorological and Environmental Research2019，10，4： | 0 |
| 13 | Monitoring and Evaluation of Environmental Quality of the Waters near the Oujiang River Estuary in Wenzou显示文摘Based on the monitoring results of environmental quality of the waters near the Oujiang River estuary from 2010 to 2017,the present situation of environmental quality of the waters was analyzed and evaluated.The results showed that pH,DO,COD Mn ,petroleum,and heavy metal (Cu,Pb,Zn,Cd,Hg,As and Cr) content in the waters near the Oujiang River estuary did not exceed the second-class standard of Seawater Quality Standard (GB 3097-1997),while both inorganic nitrogen and reactive phosphate in the waters greatly exceeded the second-class standard.The water quality near the Oujiang River estuary was in an eutrophic state.In terms of sediment quality,the standard index of most evaluation factors except for Cu was smaller than 1,meeting the demands of sediment quality for environmental protection. | Lin Bo Zhang Haifeng Yao Dongping Qian Jian Zheng Fangqin Ye Xinrong | 2019 | Meteorological and Environmental Research2019，10，5： | 0 |
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