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| 1 | Near-resonance enhanced label-free stimulated Raman scattering microscopy with spatial resolution near 130 nm显示文摘High-resolution optical microscopes that can break 180 nm in spatial resolution set to conventional microscopies are much-needed tools.However,current optical microscopes have to rely on exogenous fluorescent labels to achieve high resolution in biological imaging.Herein,we report near-resonance enhanced label-free stimulated Raman scattering(SRS)microscopy with a lateral resolution near 130 nm,in which the high-resolution image contrast originates directly from a low concentration of endogenous biomolecules,with sensitivity gains of approximately 23 times.Moreover,by using a 0.3-m-long optical fiber,we developed hyperspectral SRS microscopy based on spectral focusing technology.Attributed to enhancements in spatial resolution and sensitivity,we demonstrated highresolution imaging of three-dimensional structures in single cells and high-resolution mapping of large-scale intact mouse brain tissues in situ.By using enhanced high-resolution hyperspectral SRS,we chemically observed sphingomyelin distributed in the myelin sheath that insulates single axons.Our concept opens the door to biomedical imaging with~130 nm resolution. | Yali Bi Chi Yang Yage Chen Shuai Yan Guang Yang Yaozu Wu Guoping Zhang Ping Wang | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | Climatology and seasonal variability of satellite-derived chlorophyll a around the Shandong Peninsula显示文摘The chlorophyll a(Chl a)is an important indicator of marine ecosystems.The spatiotemporal variation of the Chl a greatly aff ects the mariculture and marine ranching in coastal waters of the Shandong Peninsula.In the current study,the climatology and seasonal variability of surface Chl-a concentration around the Shandong Peninsula are investigated based on 16 years(December 2002-November 2018)of satellite observations.The results indicate that the annual mean Chl-a concentration is greater in the Bohai Sea than in the Yellow Sea and decreases from coastal waters to off shore waters.The highest Chl-a concentrations are found in Laizhou Bay(4.2-8.0 mg/m^(3)),Haizhou Bay(4.2-5.9 mg/m^(3))and the northeast coast of the Shandong Peninsula(4.4-5.0 mg/m^(3)),resulting from the combined eff ects of the intense riverine input and long residence time caused by the concave shape of the coastline.The seasonal Chl-a concentration shows a significant spatial variation.The Chl-a concentrations in these three subregions generally exhibit an annual maximum in August/September,due to the combined eff ects of sea surface temperature,river discharge and sea surface wind.In the southeast coast region,however,the Chl-a concentration is lowest throughout the year and reaches a maximum in February with a minimum in July,forced by the seasonal evolution of the Yellow Sea Cold Water and monsoon winds.The interannual Chl-a concentration trends vary among regions and seasons.There are significant increasing trends over a large area around Haizhou Bay from winter to summer,which are mainly caused by the rising sea surface temperature and eutrophication.In other coastal areas,the Chl-a concentration shows decreasing trends,which are clearest in summer and induced by the weakening land rainfall.This study highlights the differences in the Chl-a dynamics among regions around the Shandong Peninsula and is helpful for further studies of coupled physical-ecological-human interactions at multiple scales. | Xiukai SONG Yanzhen GU Fangguo ZHAI Peiliang LI Pengxia LIU Zizhou LIU Wenfan WU Yaozu CHEN Xiangyang JIANG Jianlong HE | 2021 | Journal of Oceanology and Limnology2021，39，4： | 3 |
| 3 | Field synergy principle of heat and mass transfer显示文摘Simultaneous heat and mass transfer widely exists in nature and engineering, and it is of vital importance to enhance heat and mass transfer efficiency. In this paper, field synergy equation of heat and mass transfer is derived from its energy equation. Results show that the total transferred heat (including the conducted heat and the heat transferred by mass diffusion through the heat transfer interface) is determined by the values of fluid velocity and enthalpy gradient as well as the value of synergy angle α of velocity vector and enthalpy gradient field. Decreasing the value of α enhances the heat and mass transfer. This means the higher the synergy of velocity vector and enthalpy gradient field, the higher the total transferred heat. By the synergy principle of heat and mass transfer, some methods may be developed to improve the heat and mass transfer efficiency. | WU LiangBo LI Zhen SONG YaoZu | 2009 | Chinese Science Bulletin2009，54，24： | 2 |
| 4 | Digital Simulation of Projective Non-Abelian Anyons with 68 Superconducting Qubits显示文摘Non-Abelian anyons are exotic quasiparticle excitations hosted by certain topological phases of matter.They break the fermion-boson dichotomy and obey non-Abelian braiding statistics:their interchanges yield unitary operations,rather than merely a phase factor,in a space spanned by topologically degenerate wavefunctions.They are the building blocks of topological quantum computing.However,experimental observation of non-Abelian anyons and their characterizing braiding statistics is notoriously challenging and has remained elusive hitherto,in spite of various theoretical proposals.Here,we report an experimental quantum digital simulation of projective non-Abelian anyons and their braiding statistics with up to 68 programmable superconducting qubits arranged on a two-dimensional lattice.By implementing the ground states of the toric-code model with twists through quantum circuits,we demonstrate that twists exchange electric and magnetic charges and behave as a particular type of non-Abelian anyons,i.e.,the Ising anyons.In particular,we show experimentally that these twists follow the fusion rules and non-Abelian braiding statistics of the Ising type,and can be explored to encode topological logical qubits.Furthermore,we demonstrate how to implement both single-and two-qubit logic gates through applying a sequence of elementary Pauli gates on the underlying physical qubits.Our results demonstrate a versatile quantum digital approach for simulating non-Abelian anyons,offering a new lens into the study of such peculiar quasiparticles. | Shibo Xu Zheng-Zhi Sun Ke Wang Liang Xiang Zehang Bao Zitian Zhu Fanhao Shen Zixuan Song Pengfei Zhang Wenhui Ren Xu Zhang Hang Dong Jinfeng Deng Jiachen Chen Yaozu Wu Ziqi Tan Yu Gao Feitong Jin Xuhao Zhu Chuanyu Zhang Ning Wang Yiren Zou Jiarun Zhong Aosai Zhang Weikang Li Wenjie Jiang Li-Wei Yu Yunyan Yao Zhen Wang Hekang Li Qiujiang Guo Chao Song H.Wang Dong-Ling Deng | 2023 | Chinese Physics Letters2023，40，6： | 0 |
| 5 | Consistent apparent Young’s modulus of human embryonic stem cells and derived cell types stabilized by substrate stiffness regulation promotes lineage specificity maintenance显示文摘Background:Apparent Young’s modulus(AYM),which reflects the fundamental mechanical property of live cells measured by atomic force microscopy and is determined by substrate stiffness regulated cytoskeletal organization,has been investigated as potential indicators of cell fate in specific cell types.However,applying biophysical cues,such as modulating the substrate stiffness,to regulate AYM and thereby reflect and/or control stem cell lineage specificity for downstream applications,remains a primary challenge during in vitro stem cell expansion.Moreover,substrate stiffness could modulate cell heterogeneity in the single-cell stage and contribute to cell fate regulation,yet the indicative link between AYM and cell fate determination during in vitro dynamic cell expansion(from single-cell stage to multi-cell stage)has not been established.Results:Here,we show that the AYM of cells changed dynamically during passaging and proliferation on substrates with different stiffness.Moreover,the same change in substrate stiffness caused different patterns of AYM change in epithelial and mesenchymal cell types.Embryonic stem cells and their derived progenitor cells exhibited distinguishing AYM changes in response to different substrate stiffness that had significant effects on their maintenance of pluripotency and/or lineage-specific characteristics.On substrates that were too rigid or too soft,fluctuations in AYM occurred during cell passaging and proliferation that led to a loss in lineage specificity.On a substrate with‘optimal’stiffness(i.e.,3.5 kPa),the AYM was maintained at a constant level that was consistent with the parental cells during passaging and proliferation and led to preservation of lineage specificity.The effects of substrate stiffness on AYM and downstream cell fate were correlated with intracellular cytoskeletal organization and nuclear/cytoplasmic localization of YAP.Conclusions:In summary,this study suggests that optimal substrate stiffness regulated consistent AYM during passaging and proliferation reflects and contributes to hESCs and their derived progenitor cells lineage specificity maintenance,through the underlying mechanistic pathways of stiffness-induced cytoskeletal organization and the downstream YAP signaling.These findings highlighted the potential of AYM as an indicator to select suitable substrate stiffness for stem cell specificity maintenance during in vitro expansion for regenerative applications. | Anqi Guo Bingjie Wang Cheng Lyu Wenjing Li Yaozu Wu Lu Zhu Ran Bi Chenyu Huang Jiao Jiao Li Yanan Du | 2020 | Cell Regeneration2020，9，1： | 0 |
| 6 | Soliton frequency comb generation in CMOS-compatible silicon nitride microresonators显示文摘The monolithic integration of soliton microcomb devices with active photonic components and high-frequency electronics is highly desirable for practical applications. Among many materials, silicon nitride(SiN_(x)) waveguide layers prepared by low-pressure chemical vapor deposition(LPCVD) have been the main platform for on-chip optical frequency comb generation. However, the high temperatures involved in LPCVD render it incompatible as a back-end process with complementary metal oxide semiconductor(CMOS) or active Ⅲ-Ⅴ compound semiconductor fabrication flows. We report the generation of coherent soliton frequency combs in micro-ring resonators fabricated in deuterated silicon nitride(SiN_(x):D) waveguides with a loss of 0.09 d B/cm. Deposited at 270℃ by an inductance-coupled plasma chemical vapor deposition(ICP-CVD) process, the material preparation and fabrication flow are fully CMOS-compatible. These results enable the integration of silicon-nitride-based optical combs and photonic integrated circuits(PICs) on prefabricated CMOS and/or Ⅲ-Ⅴ substrates, therefore marking a major step forward in Si Nxphotonic technologies. | YAOZU XIE JIAQI LI YANFENG ZHANG ZERU WU SHIHAO ZENG SHUQING LIN ZHAOYANG WU WENCHAO ZHOU YUJIE CHEN SIYUAN YU | 2022 | Photonics Research2022，10，5： | 0 |
| 7 | A Textual Research on Materia Medica of Origin of Orthonym and Synonym of Cuscutae Semen显示文摘A textual research on materia medica of origin of orthonym and synonym of Cuscutae Semen and synonym of Nu Luo was conducted in this study,and the trade name,regional synonym and nickname of Cuscutae Semen were reviewed.The records of orthonym and synonym of Cuscutae Semen in the past dynasties,and the first published literature and writing date of orthodox and synonym were summarized.The textual research showed that Nu Luo and Cuscutae Semen were not the same plant,which had positive significance for the identification of the origin and modern application of Cuscutae Semen. | Xiali WU Dongxue BAI Cheng SONG Yaozu XIONG Jia LU Yanhui ZHAO | 2021 | Medicinal Plant2021，12，1： | 0 |
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