| 1 | Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis显示文摘Metastasis is a major cause of chemotherapeutic failure and death.Degradation of a specific component of the extracellular matrix(ECM)by matrix metalloproteinases(MMPs)affects the physical barrier of the tumor microenvironment(TME)and induces metastasis.Here,lysolipid-containing thermosensitive liposomes(LTSLs)were prepared to deliver an MMP inhibitor,marimastat(MATT),to the TME to inhibit MMP activity and expression.LTSLs rapidly released their payloads at 42°C.Compared with the saline control,MATT-LTSLs exhibited enhanced accumulation in the tumor and a 20-fold decrease in tumor growth in 4T1 tumor-bearing mice;moreover,MATT-LTSLs reduced MMP-2 and MMP-9 activity by 50%and 43%,respectively,and downregulated MMP-2 and MMP-9 expression in vivo by 30%and 43%,respectively.Most importantly,MATT-LTSL treatment caused a 7-fold decrease in metastatic lung nodules and a 6-fold reduction in microvessels inside the tumor.We believe this study provides an effective approach for the suppression of metastasis,and the use of a cytotoxic agent in combination with MATT is a potential strategy for metastatic cancer treatment. | Yaqi Lyu Qingqing Xiao Lifang Yin Lei Yang Wei He | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 5 |
| 2 | Adjuvant chemotherapy may improve outcome of patients with non-small-cell lung cancer with metastasis of intrapulmonary lymph nodes after systematic dissection of N1 nodes显示文摘Objective: Survival benefit of adjuvant chemotherapy(AC) of patients with intrapulmonary lymph node(IPLN)metastasis(level 12-14) needs investigation.We evaluated the impact of AC on patients whose metastatic nodes were limited to intrapulmonary levels after systematic dissection of N1 nodes.Methods: First,155 consective cases of lung cancer confirmed as pathologic N1 were collected and evaluated.Patients received systematic dissection of N2 and N1 nodes.For patients with IPLN metastasis,survival outcomes were compared between those receiving AC and those not receiving AC.Results: In this group,112 cases(72.3%) had IPLN metastasis and 55 cases(35.5%) had N1 involvement limited to level 13-14 without further disease spread to higher levels.Patients with IPLN involvement had a better prognosis than that of patients with hilar-interlobar involvement.For the intrapulmonary N1 group(level 12-14-positive,level 10-11-negative or unknown,n=112),no survival benefit was found between the AC group and nonAC group [5-year overall survival(OS): 54.6±1.6 vs.50.4±2.4 months,P=0.177].However,76 of 112 cases for whom harvesting of level-10 and level-11 nodes was done did not show cancer involvement in pathology reports(level 12-14-positive,level 10-11 both negative),oncologic outcome was better for patients receiving AC than those not receiving AC in this subgroup(5-year OS: 57.3±1.5 vs.47.1±3.2 months,P=0.002).Conclusions: Oncologic outcome may be improved by AC for patients with involvement of N1 nodes limited to intrapulmonary levels after complete examination of N1 nodes. | Xing Wang Shi Yan Yaqi Wang Xiang Li Chao Lyu Yuzhao Wang Jia Wang Shaolei Li Lijian Zhang Yue Yang Nan Wu | 2018 | Chinese Journal of Cancer Research2018，30，6： | 2 |
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