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| 1 | ASPP Proteins Specifically Stimulate the Apoptotic Function of p53显示文摘 | Yardena Samuels-Lev Daniel J. O’Connor Daniele Bergamaschi Giuseppe Trigiante Jung-Kuang Hsieh Shan Zhong Isabelle Campargue Louie Naumovski Tim Crook Xin Lu | 2001 | Molecular Cell2001，，4： | 1 |
| 2 | Cloning and molecular characterization of an ethylene receptor gene, MiERSl,expressed during mango fruitlet abscission and fruit ripening 显示文摘 | I S Mazal Yardena D Inbar M | 2011 | Plant Physiology and Biochemistry2011，49，： | 1 |
| 3 | Salt and oxidative stress:similar and specific responses and their relation to salt tolerance in Citrus显示文摘 | Yardena Gueta-Dahan | 1997 | Planta1997，203，： | 1 |
| 4 | Oncogenic mutations of PIK3CA in human cancers 显示文摘 | Yardena S Victor EV | 2004 | Cell Cycle2004，3，： | 1 |
| 5 | Salt and oxidative stress: similar and specific responses and their relation to salt tolerance in Citrus显示文摘 | Yardena Gueta-Dahan Zohara Yaniv Barbara A. Zilinskas Gozal Ben-Hayyim | 1997 | Planta1997，，4： | 1 |
| 6 | ASPP Proteins Specifically stimulate the Apoptosis Function of p53 显示文摘 | Yardena Samuels - Lev | 2001 | Molecular cell2001，8，： | 1 |
| 7 | Professionalism and organizational citizenship behavior: An empirical examination among Israeli nurses显示文摘 | Cohen Aaron Kol Yardena | 2004 | Journal of Managerial Psychology2004，19，4： | 1 |
| 8 | The saltstress signal transduetion pathway that activates the gpx1 promoter is mediated by intracellular H2O2, different from the pathway induced by extracellular H2O2 显示文摘 | Orna A K Yardena G D Simcha L Y | 2004 | Plant Physiology2004，135，： | 1 |
| 9 | Multidrug-Resistant Pseudomonas aeruginosa:Risk Factors and Clinical Impact显示文摘 | Valerie Aloush Shiri Navon Venezia Yardena Seigman Igra | 2006 | Antimicrob Agents Chemother2006，50，1： | 1 |
| 10 | Salt and oxidative stress: similar and specific responses and their relation to salt tolerance in Citrus显示文摘 | Yardena Gueta-Dahan Zohara Yaniv Barbara A. Zilinskas Gozal Ben-Hayyim | 1997 | Planta1997，，4： | 1 |
| 11 | Multidrug-Resistant Pseudomonas aeruginosa: Risk Factors and Clinical Impact显示文摘 | Valerie Aloush Shiri Navon-Venezia Yardena Seigman-Igra et al | 2006 | Antimicrobial Agents and Chemotherapy2006，50，： | 1 |
| 12 | Oncogenic mutations of PIK3 CA in human cancers显示文摘 | Yardena Samuels Todd Waldman | 2010 | Curr Top Microbiol Immunol2010，347，： | 1 |
| 13 | Listeria mono- cytogenes Infection in Israel and Review of Cases Worldwide显示文摘 | Yardena Siegman-Igra Rotem Levin Miriam Weinberger | 2002 | Emerging Infectious Diseases2002，8，3： | 1 |
| 14 | Multidrug-resistant pseudomonas aeruginosa:risk factors and clinical impact显示文摘 | Valerie A Shiri NV Yardena SI | 2006 | Antimicrobial Agents and Chemotherapy2006，50，1： | 1 |
| 15 | Preferential induction of a 9-1ipoxygenase by salt in salt-tolerant cells of Citrus sinensis L Osbeck显示文摘 | Gozal Ben-Hayyim Yardena Gueta-Dahan Oma Avsian- Kretchmer | 2001 | Planta2001，212，： | 1 |
| 16 | Muhidrug-Resistant Psendomonas aeruginosa:Risk Factors and Clinical Impact显示文摘 | Valerie Aloush Shift Navon-Venezia Yardena Seigman-Igra | 2006 | Antimicrobial Agents and Chemotherapy2006，50，： | 1 |
| 17 | A proposed conserved role for an avocado fw2.2 - like gene as a negative regulator of fruit cell division显示文摘 | Yardena Dahan Revital Rosenfeld Victor Zadiranov Vered Irihimovitch | 2010 | Planta2010，，3： | 1 |
| 18 | Mutant PIK3CA promotes cell growth and invasion of human cancer cells显示文摘 | Yardena Samuels Luis A. Diaz Oleg Schmidt-Kittler Jordan M. Cummins Laura DeLong Ian Cheong Carlo Rago David L. Huso Christoph Lengauer Kenneth W. Kinzler Bert Vogelstein Victor E. Velculescu | 2005 | Cancer Cell2005，，6： | 1 |
| 19 | ERRα regulates the growth of triple-negative breast cancercells via S6K1-dependent mechanism显示文摘Estrogen-related receptor alpha(ERRα)is an orphan nuclear factor that is a master regulator of cellular energy metabolism.ERRαis overexpressed in a variety of tumors,including ovarian,prostate,colorectal,cervical and breast,and is associated with a more aggressive tumor and a worse outcome.In breast cancer,specifically,high ERRαexpression is associated with an increased rate of recurrence and a poor prognosis.Because of the common functions of ERRαand the mTORC1/S6K1 signaling pathway in regulation of cellular metabolism and breast cancer pathogenesis,we focused on investigating the biochemical relationship between ERRαand S6K1.We found that ERRαnegatively regulates S6K1 expression by directly binding to its promoter.Downregulation of ERRαexpression sensitized ERα-negative breast cancer cells to mTORC1/S6K1 inhibitors.Therefore,our results show that combinatorial inhibition of ERRαand mTORC1/S6K1 may have clinical utility in treatment of triple-negative breast cancer,and warrants further investigation. | Adi Y Berman Subrata Manna Naomi S Schwartz Yardena E Katz Yang Sun Catherine A Behrmann Jane J Yu David R Plas Anya Alayev Marina K Holz | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 20 | Parkin Somatic Mutations Link Melanoma and Parkinson's Disease显示文摘Epidemiological studies suggest a direct link between melanoma and Parkinson's disease(PD); however, the underlying molecular basis is unknown. Since mutations in Parkin are the major driver of early-onset PD and Parkin was recently reported to play a role in cancer development, we hypothesized that Parkin links melanoma and PD. By analyzing whole exome/genome sequencing of Parkin from 246 melanoma patients, we identified five non-synonymous mutations, three synonymous mutations, and one splice region variant in Parkin in3.6% of the samples. In vitro analysis showed that wild-type Parkin plays a tumor suppressive role in melanoma development resulting in cell-cycle arrest, reduction of metabolic activity, and apoptosis. Using a mass spectrometry-based analysis, we identified potential Parkin substrates in melanoma and generated a functional protein association network. The activity of mutated Parkin was assessed by protein structure modeling and examination of Parkin E3 ligase activity. The Parkin-E28 K mutation impairs Parkin ubiquitination activity and abolishes its tumor suppressive effect. Taken together, our analysis of genomic sequence and in vitro data indicate that Parkin is a potential link between melanoma and Parkinson's disease. Our findings suggest new approaches for early diagnosis and treatment against both diseases. | Lotan Levin Shani Srour Jared Gartner Oxana Kapitansky Nouar Qutob Shani Dror Tamar Golan Roy Dayan Ronen Brener Tamar Ziv Mehdi Khaled Ora Schueler-Furman Yardena Samuels Carmit Levy | 2016 | Journal of Genetics and Genomics2016，43，6： | 0 |
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