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| 1 | Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?显示文摘AIM To investigate the correlation of iodine concentration(IC) generated by spectral computed tomography(CT) with micro-vessel density(MVD) and vascular endothelial growth factor(VEGF) expression in patients with advanced gastric carcinoma(GC).METHODS Thirty-four advanced GC patients underwent abdominal enhanced CT in the gemstone spectral imaging mode. The IC of the primary lesion in the arterial phase(AP) and venous phase(VP) were measured, and were then normalized against that in the aorta to provide the normalized IC(nI C). MVD and VEGF were detected by immunohistochemical assays, using CD34 and VEGF-A antibodies, respectively. Correlations of nI C with MVD, VEGF, and clinical-pathological features were analyzed.RESULTS Both nI Cs correlated linearly with MVD and were higher in the primary lesion site than in the normal control site, but were not correlated with VEGF expression. After stratification by clinical-pathological subtypes, nI C-AP showed a statistically significant correlation with MVD, particularly in the group with tumors at stage T4, without nodular involvement, of a mixed Lauren type, where the tumor was located at the antrum site, and occurred in female individuals. nI C-VP showed a positive correlation with MVD in the group with the tumor at stage T4 and above, had nodular involvement, was poorly differentiated, was located at the pylorus site, of a mixed and diffused Lauren subtype, and occurred in male individuals. nI C-AP and nI C-VP showed significant differences in terms of histological differentiation and Lauren subtype.CONCLUSION The IC detected by spectral CT correlated with the MVD. n IC-AP and n IC-VP can reflect angiogenesis in different pathological subgroups of advanced GC. | Xiao-Hua Chen Ke Ren Pan Liang Yaru Chai Kui-Sheng Chen Jian-Bo Gao | 2017 | World Journal of Gastroenterology2017，23，9： | 47 |
| 2 | Spatial and temporal variation of particulate matter and gaseous pollutants in 26 cities in China显示文摘O3and PM2.5were introduced into the newly revised air quality standard system in February 2012, representing a milestone in the history of air pollution control, and China's urban air quality will be evaluated using six factors(SO2, NO2, O3, CO, PM2.5and PM10) from the beginning of 2013. To achieve the new air quality standard, it is extremely important to have a primary understanding of the current pollution status in various cities. The spatial and temporal variations of the air pollutants were investigated in 26 pilot cities in China from August 2011 to February 2012, just before the new standard was executed. Hourly averaged SO2, NO2and PM10were observed in 26 cities, and the pollutants O3, CO and PM2.5were measured in 15 of the 26 cities. The concentrations of SO2and CO were much higher in the cities in north China than those in the south. As for O3and NO2, however, there was no significant diference between northern and southern cities. Fine particles were found to account for a large proportion of airborne particles, with the ratio of PM2.5to PM10ranging from 55% to 77%. The concentrations of PM2.5(57.5 μg/m3) and PM10(91.2 μg/m3) were much higher than the values(PM2.5: 11.2 μg/m3; PM10 : 35.6 μg/m3) recommended by the World Health Organization. The attainment of the new urban air quality standard in the investigated cities is decreased by 20% in comparison with the older standard without considering O3, CO and PM2.5, suggesting a great challenge in urban air quality improvement, and more eforts will to be taken to control air pollution in China. | Fahe Chai Jian Gao Zhenxing Chen Shulan Wang Yuechong Zhang Jingqiao Zhang Hefeng Zhang Yaru Yun Chun Ren | 2014 | Journal of Environmental Sciences2014，26，1： | 36 |
| 3 | Chemical composition and source apportionment of PM10 and PM2.5 in different functional areas of Lanzhou,China显示文摘To elucidate the air pollution characteristics of northern China, airborne PM_10(atmospheric dynamic equivalent diameter ≤ 10 μm) and PM_(2.5)(atmospheric dynamic equivalent diameter ≤ 2.5 μm) were sampled in three different functional areas(Yuzhong County,Xigu District and Chengguan District) of Lanzhou, and their chemical composition(elements, ions, carbonaceous species) was analyzed. The results demonstrated that the highest seasonal mean concentrations of PM_10(369.48 μg/m^3) and PM_(2.5)(295.42 μg/m^3) were detected in Xigu District in the winter, the lowest concentration of PM_(2.5)(53.15 μg/m^3) was observed in Yuzhong District in the fall and PM_10(89.60 μg/m^3) in Xigu District in the fall.The overall average OC/EC(organic carbon/elemental carbon) value was close to the representative OC/EC ratio for coal consumption, implying that the pollution of Lanzhou could be attributed to the burning of coal. The content of SNA(the sum of sulfate, nitrate,ammonium, SNA) in PM_(2.5)in Yuzhong County was generally lower than that at other sites in all seasons. The content of SNA in PM_(2.5)and PM_10 in Yuzhong County was generally lower than that at other sites in all seasons(0.24–0.38), indicating that the conversion ratios from precursors to secondary aerosols in the low concentration area was slower than in the area with high and intense pollutants. Six primary particulate matter sources were chosen based on positive matrix factorization(PMF) analysis, and emissions from dust, secondary aerosols, and coal burning were identified to be the primary sources responsible for the particle pollution in Lanzhou. | Xionghui Qiu Lei Duan Jian Gao Shulan Wang Fahe Chai Jun Hu Jingqiao Zhang Yaru Yun | 2016 | Journal of Environmental Sciences2016，28，2： | 33 |
| 4 | Colorectal cancer and adjacent normal mucosa differ in apoptotic and inflammatory protein expression显示文摘Colorectal cancer usually refers to the occurrence of the appendix,rectum or colon and other parts of the ma-lignant tumor in the large intestine mucosa and glands,is also one of the most common malignant tumors in human.In recent years,studies have shown that chronic inflammation is the'initiator'of cancer.Inflammation plays a causal role in the early formation of tumors by regulating the initiation and promotion of tumor genesis and development through a series of inflammatory cytokines.Inflammation plays a causal role in the early for-mation of tumors by regulating the initiation and promotion of tumor genesis and development through a series of inflammatory cytokines.The latter part of this review describes the role of several important inflammatory factors:tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and transforming growth factor-β(TGF-β)in col-orectal cancer.In normal mucosa,inflammatory factors play an important role in the immune response of the body.However,when a large number of inflammatory factors accumulate,they will cause pathological damage to the body,trigger inflammation and even deteriorate into cancer.Serum levels of most inflammatory factors were low in healthy controls,but were elevated in colorectal cancer patients.Here,we review the relationship be-tween apoptosis,inflammation and cancer,and analyze the difference in the expression of inflammatory proteins in colorectal cancer and its adjacent mucosa. | Xiaojing Sun Zhonghua Xue Aqeela Yasin Yingkun He Yaru Chai Jingan Li Kun Zhang | 2021 | Engineered Regeneration2021，2，1： | 0 |
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