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| 1 | Associations of Polymorphism of rs9944155, rs1051052, and rs1243166 Locus Allele in Alpha-1-antitrypsin with Chronic Obstructive Pulmonary Disease in Uygur Population of Kashgar Region显示文摘 | Xue-Mei Zhong Li Li Huai-Zhen Wang Xiao-Guang Zou Ping Zhang Mireban Rexiati Maimaitiaili Tnerxun Jie Ren Mukeremu Yasen Juan Zhang Ai-Fang Zheng Paierda Aini | 2018 | Chinese Medical Journal2018，，6： | 3 |
| 2 | Performance measures in evaluating machine learning based bioinformatics predictors for classifications显示文摘 | Yasen Jiao Pufeng Du | 2016 | Frontiers of Electrical and Electronic Engineering in China2016，4，4： | 3 |
| 3 | Left trisectionectomy and supra-hepatic caval reconstruction with vascular prosthesis for chronic Budd-Chiari syndrome caused by hepatic alveolar echinococcosis显示文摘To the Editor:Hepatic alveolar echinococcosis(AE)is a lethal infectious disease caused by the larval stage Echinococcus multilocularis(E.multilocularis)and exhibits low prevalence in endemic areas with high morbidity and mortality.AE lesions invading the hepato-caval confluence,including main hepatic veins and retro-hepatic inferior vena cava(IVC),may result in Budd-Chiari Syndrome(BCS),which was a severe complication of AE presented with abdominal pain,ascites,and hepatomegaly.In this study,we reported a case of chronic BCS caused by hepatic AE and summarized the therapeutic method of left trisectionectomy and supra-hepatic IVC replacement with prosthetic grafts. | Bo Ran Tie-Min Jiang Aimaiti Yasen Abudusalamu Aini Qiang Guo Rui-Qing Zhang Ying-Mei Shao Hao Wen Aji Tuerganaili | 2019 | Chinese Medical Journal2019，，23： | 2 |
| 4 | Genome Array on Differentially Expressed Genes of Skin Tissue in Cashmere Goat at Early Anagen of Cashmere Growth Cycle Using DNA Microarray显示文摘In order to study the molecular mechanism involved in cashmere regeneration, this study investigated the gene expression profile of skin tissue at various stages of the cashmere growth cycle and screen differentially expressed genes at proangen in 10 cashmere goats at 2 years of age using agilent sheep oligo microarray. Significance analysis of microarray(SAM) methods was used to identify the differentially expressed genes, Hierarchical clustering was performed to clarify these genes in association with different cashmere growth stages, and GO(Gene ontology) and the pathway analyses were con-ducted by a free web-based Molecular Annotation System3.0(MAS 3.0). Approximately 10 200 probe sets were detected in skin tissue of 2-yr-old cashmere goat. After SAM analysis of the microarray data, totally 417 genes were shown to be differentially expressed at different cashmere growth stages, and 24 genes are significantly up-regulated(21) or down-regulated(3) at proangen concurrently compared to angen and telogen. Hierarchical clustering analysis clearly distinguished the differentially expressed genes of each stage. GO analysis indicated that these altered genes at proangen were predominantly involved in collagen fibril organization, integrin-mediated signaling pathway, cell-matrix adhesion, cell adhesion, transforming growth factor-β(TGF-β) receptor signaling pathway, regulation of cell growth. Kyoto encyclopedia of genes and genomes(KEGG) analysis showed that the significant pathways involved mainly included focal adhesion and extracellular matrixc(ECM)-receptor interaction. Some important genes involved in these biological processes, such as COL1A1, COL1A2, COL3A1, SPARC, CYR61 and CTGF, were related to tissue remolding and repairing and detected by more than one probe with similar expression trends at different stages of cashmere growth cycle. The different expression of these genes may contribute to understanding the molecular mechanism of cashmere regeneration. | DI Jiang XU Xin-ming Lazate Ainiwaer ZHANG Yan-hua TIAN Ke-chuan YU Li-juan WU Wei-wei Hanikezi Tulafu FU Xue-feng Marzeya Yasen | 2014 | Journal of Integrative Agriculture2014，13，10： | 2 |
| 5 | Determination of seven synthetic dyes in animal feeds and meat by high performance liquid chromatography with diode army and tandem mass detectors显示文摘 | T Zou P He A Yasen | 2013 | Food Chem2013，138，23： | 1 |
| 6 | Expression of CD4 CD25 regulatory T cells and TGF-II in patient with idiopathic thrombocyto- penic purpura显示文摘 | Abudureheman A Yasen H Fang Z | 2010 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2010，26，9： | 1 |
| 7 | Oxidative stress pathways in noncancerous human liver tissue to predict hepatocellular carcinoma recurrence:A prospective,multicenter study显示文摘 | Tanaka S Mogushi K Yasen M | 2011 | Hepatology2011，54，4： | 1 |
| 8 | The selective Aurora-B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma显示文摘 | Aihara A Tanaka S J Yasen M | | 0，，01： | 1 |
| 9 | The histologic effects of the Uyghur medicine Xipayi KuiJiean on ulcerative colitis in rats 显示文摘 | Halmurat U Kurexi Y Yasen M | 2011 | JAust Tradit-Med Soc2011，17，4： | 1 |
| 10 | The selective Aurora B kinase inhibitor AZDl152 as a novel treatment for hepatocellular carcinoma 显示文摘 | Aihara A Tanaka S Yasen M et at | 2010 | J Hepatol2010，52，1： | 1 |
| 11 | Determination of seven synthetic dyes in animal feeds and meat by high performance liquid chromatography with diode array and tandem mass detectors显示文摘 | Tingting Zou Pingli He Amangul Yasen Zhen Li | 2013 | Food Chemistry (-)2013，，2： | 1 |
| 12 | Expression of Aurora B and alternative variant forms in hepatocellular carcinoma and adjacent tissue显示文摘 | Yasen M Mizushima H Mogushi K | 2009 | Cancer Sci2009，100，3： | 1 |
| 13 | The up-regulation of Y-box bind- ing proteins (DNA binding protein A and Y-box binding protein-1 ) as prognostic markers of hepatoeellular carcinoma 显示文摘 | Yasen M Kajino K Kano S | 2005 | Clin Cancer Res2005，11，20： | 1 |
| 14 | Upregulation of protein tyro- sine phosphatase type IVA member 3 ( PTP4A3/PRL-3 ) is associated with tumor differentiation and a poor prognosis in human bepatocellu- lar carcinoma显示文摘 | Mayinuer A Yasen M Mognshi K | 2013 | Ann Surg Oncol2013，20，1： | 1 |
| 15 | Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα显示文摘The acute promyelocytic leukemia(APL)driver ZBTB16/RARαis generated by the t(11;17)(q23;q21)chromosomal translocation,which is resistant to combined treatment of all-trans retinoic acid(ATRA)and arsenic trioxide(ATO)or conventional chemotherapy,resulting in extremely low survival rates.In the current study,we investigated the effects of hyperthermia on the oncogenic fusion ZBTB16/RARαprotein to explore a potential therapeutic approach for this variant APL.We showed that Z/R fusion protein expressed in HeLa cells was resistant to ATO,ATRA,and conventional chemotherapeutic agents.However,mild hyperthermia(42℃)rapidly destabilized the ZBTB16/RARαfusion protein expressed in HeLa,293T,and OCI-AML3 cells,followed by robust ubiquitination and proteasomal degradation.In contrast,hyperthermia did not affect the normal(i.e.,unfused)ZBTB16 and RARαproteins,suggesting a specific thermal sensitivity of the ZBTB16/RARαfusion protein.Importantly,we found that the destabilization of ZBTB16/RARαwas the initial step for oncogenic fusion protein degradation by hyperthermia,which could be blocked by deletion of nuclear receptor corepressor(NCoR)binding sites or knockdown of NCoRs.Furthermore,SIAH2 was identified as the E3 ligase participating in hyperthermia-induced ubiquitination of ZBTB16/RARα.In short,these results demonstrate that hyperthermia could effectively destabilize and subsequently degrade the ZBTB16/RARαfusion protein in an NCoR-dependent manner,suggesting a thermal-based therapeutic strategy that may improve the outcome in refractory ZBTB16/RARα-driven APL patients in the clinic. | Qian-qian Wang Liaqat Hussain Pei-han Yu Chang Yang Chen-ying Zhu Ya-fang Ma Si-chun Wang Tao Yang Yuan-yuan Kang Wen-juan Yu Yasen Maimaitiyiming Hua Naranmandura | 2023 | Acta Pharmacologica Sinica2023，44，4： | 1 |
| 16 | Economy, environmental assessment and energy conservation for separation of isopropanol/diisopropyl ether/water multi-azeotropes via extractive distillation coupled pervaporation process显示文摘This wok proposed the extraction distillation coupled pervaporation(ED+PV) technology process using two different solvents to separate isopropanol(IPA) and diisopropyl ether(DIPE) from DIPE/IPA/H_(2)O ternary heterogeneous azeotropes in industrial wastewater from the synthesis of isopropanol in this study.Based on strict design specifications, simulation and sequential iteration methods are used for process design and optimization. Compared to the ethylene glycol(EG)-EG+H_(2)O process and the 1,3-propanediol(PDO)-IPA+H_(2)O process, the total annual cost(TAC) of the EG-IPA+H_(2)O process decreased by 20.76% and 7.86%(PDO). Compared to the EG-EG+H_(2)O process, the TAC of the PDO-IPA+H_(2)O process reduced 14%, but the global warming potential(GWP) and human toxicity of the PDO-IPA+H_(2)O process increased 11.3% and 4.07% respectively. Compared to the PDO-IPA+H_(2)O process, the EG-IPA+H_(2)O process saves 7.86%(TAC), 9.78%(GWP) and 9.85%(human toxicity). The ED+PV process with EG is superior to PDO in factors of TAC, energy consumption, human toxicity and environment. The EG-IPA+H_(2)O process changed the separation order of the products of the multi-azeotropic system, reduced the cost and energy conservation of the system, and enhanced the environmental protection evaluation of the process, is the best process through life cycle assessment for analyzing the economy, energy conservation, environmental assessment and human toxicity, designing cleaner products, controlling waste discharge, and promoting the chemical purification industry. This work provides a new process design and optimized separation ideas, will have a good guiding significance for the research and application separation of multi-azeotropic mixture with mixed solvents in organic wastewater from the cleaner chemical production, has been up to standard wastewater discharge process, and realized the development goal of carbon peak and carbon neutrality in the sustainable development of chemical clean industry. | Qinggang Xu Yasen Dai Qing Zhao Zhengrun Chen Peizhe Cui Zhaoyou Zhu Yinglong Wang Jun Gao Yixin Ma | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 1 |
| 17 | A new method on inshore ship detection in high-resolution satellite images using shape and context information显示文摘 | LIU Ge ZHANG Yasen ZHENG Xinwei | 2014 | Geoscience and Remote Sensing Letters IEEE2014，1，1： | 1 |
| 18 | The selective Au- rora - B kinase inhibitor AZD1152 as a novel treatment for hepa- tocellular carcinoma 显示文摘 | AIHARA A TANAKA S YASEN M | 2010 | Journal of Hepatology2010，52，： | 1 |
| 19 | The selective Aurora B kinase inhibitor AZDl152 as a novel treatment for hepato- cellular carcinoma显示文摘 | Aihara A Tanaka S Yasen M | 2010 | Journal of Hepatology2010，52，： | 1 |
| 20 | The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma显示文摘 | Aihara A Tanaka S Yasen M | | 0，，01： | 1 |
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