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| 1 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 2 | Controllable Biosynthesis and Properties of Gold Nanoplates Using Yeast Extract显示文摘Biosynthesis of gold nanostructures has drawn increasing concerns because of its green and sustainable synthetic process. However, biosynthesis of gold nanoplates is still a challenge because of the expensive source and difficulties of controllable formation of morphology and size. Herein, one-pot biosynthesis of gold nanoplates is proposed, in which cheap yeast was extracted as a green precursor. The morphologies and sizes of the gold nanostructures can be controlled via varying the pH value of the biomedium. In acid condition, gold nanoplates with side length from 1300 ± 200 to 300 ± 100 nm and height from 18 to 15 nm were obtained by increasing the pH value. Whereas, in neutral or basic condition, only gold nanoflowers and nanoparticles were obtained. It was determined that organic molecules, such as succinic acid, lactic acid, malic acid, and glutathione, which are generated in metabolism process, played important role in the reduction of gold ions. Besides, it was found that the gold nanoplates exhibited plasmonic property with prominent dipole infrared resonance in near-infrared region, indicating their potential in surface plasmon-enhanced applications, such as bioimaging and photothermal therapy. | Zhi Yang Zhaohui Li Xuxing Lu Fengjiao He Xingzhong Zhu Yujie Ma Rong He Feng Gao Weihai Ni Yasha Yi | 2017 | Nano-Micro Letters2017，9，1： | 2 |
| 3 | A brief review of integrated and passive photonic reservoir computing systems and an approach for achieving extra non-linearity in passive devices显示文摘Photonic-based reservoir computing(RC)systems have attracted significant attention.Integrated and purely passive systems are compatible with complementary metal-oxide-semiconductor devices,but are limited by the lack of non-linear components.This study consists of two parts:firstly,a review on the published integrated and passive RC system is presented.The review focuses on the structural configuration(rather than the mathematical model)of the neural network;secondly,a new approach for achieving an integrated and passive photonic RC system is introduced and discussed.This approach employs a mode combiner in front of the reservoir to achieve an extra non-linearity in a purely passive device.Moreover,the approach is numerically investigated,and an XOR(exclusive or)task is used to test the device,and the result shows that the new approach satisfies the requirement of an RC system. | Dachuan WU Yasha YI Yuxiao ZHANG | 2020 | Science China(Information Sciences)2020，63，6： | 1 |
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