| 1 | Chiral Bicyclic Imidazole-Catalyzed Direct Enantioselective C-Acetylation of Indolones显示文摘By adjusting the bond angle and stereocontrol substituent of the chiral bicyclic imidazole catalysts,direct enantioselective C-acetylation of indolones and their sequencial pattern have been successfully developed.Indolones bearing a quaternary stereocenter were synthesized with satisfactory yields and excellent enantioselectivities(up to 97%ee).The reaction can be realized with 410 turnover numbers,and the products can be transformed into several functional compounds via simple derivations of the acetyl group. | Muxing Zhou Yashi Zou Lu Zhang Zhenfeng Zhang Wanbin Zhang | 2023 | CCS Chemistry2023，5，2： | 0 |
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