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| 1 | Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery显示文摘AIM: To investigate the effect of compound Danshen injection on lipopolysaccharide (LPS)-induced rat mesenteric microcirculatory dysfunctions and the underlying possible mechanism by an inverted intravital microscope and high-speed video camera system. METHODS: LPS was continuously infused through the jugular artery of male Wistar rats at the dose of 2 mg/kg per hour. Changes in mesenteric microcirculation,such as diameters of arterioles and venules,velocity of RBCs in venules,leukocyte rolling,adhesion and emigration,free radicals released from post-capillary venules,FITC- albumin leakage and mast cell degranulation,were observed through an inverted intravital microscope assisted with CCD camera and SIT camera. Meanwhile,the expression of adhesion molecules CD11b/CD18 and the production of free radical in neutrophils,and the expression of intercellular adhesion molecule 1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) were quantified by flow cytometry (FACS) in vitro. RESULTS: The continuous infusion with LPS resulted in a number of responses in microcirculation,including a significant increase in the positive region of venulestained with Monastral blue B,rolling and adhesion of leukocytes,production of oxygen radical in venular wall,albumin efflux and enhanced mast cell degranulation in vivo,all of which,except for the leukocyte rolling,were attenuated by the treatment with compound Danshen injection. Experiments performed in vitro further revealed that the expression of CD11b/CD18 and the production of oxygen free radical in neutrophils,and the expression of ICAM-1 in HUVECs were increased by exposure to LPS,and they were attenuated by compound Danshen injection. CONCLUSION: These results suggest that compound Danshen injection is an efficient drug with multi-targeting potential for improving the microcirculatory disturbance. | Jing-Yan Han Yoshinori Horie Soichiro Miura, Yasutada Akiba Jun Guo Dan Li Jing-Yu Fan Yu-Ying Liu Bai-He Hu Li-Hua An Xin Chang Man Xu De-An Guo Kai Sun Ji-Ying Yang Shu-Ping Fang Ming-Ji Xian Masahiro Kizaki Hiroshi Nagata Toshifumi Hibi | 2007 | World Journal of Gastroenterology2007，13，26： | 26 |
| 2 | Diversity and seasonal changes in lactic acid bacteria in the intestinal tract of cultured fresh water fish 显示文摘 | Tatsuro H Daichi T Yasutada I | 2004 | Aquaculture2004，234，： | 1 |
| 3 | A simple and portable colorimeter using a red-green-blue light-emitting diode and its application to the on-site determination of nitrite and iron in river-water analytical显示文摘 | Yasutada S Terutomi A Hiroyuki K | 2004 | Sciences2004，20，： | 1 |
| 4 | Complete response of a highly advanced gastric carcinoma to preoperative chemoradiotherapy with S-1 and low-dose cisplatin显示文摘 | Nobunari Yoshimizu Yoshiro Saikawa Tetsuro Kubota Yasutada Akiba Masashi Yoshida Yoshihide Otani Koichiro Kumai Toshihumi Hibi Masaki Kitajima | 2003 | Gastric Cancer2003，，3： | 1 |
| 5 | Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution显示文摘 | Hiroshi Nagata Yasutada Akiba Hidekazu Suzuki Hideyuki Okano Toshifumi Hibi | 2005 | FEBS Letters2005，，1： | 1 |
| 6 | Single crystal silicon nano-wire piezoresistors for mechanical sensors显示文摘 | Toshiyuki Toriyama Yasutada Susumu Sugiyama | 2002 | Journal of Microelectromechanical System2002，11，5： | 1 |
| 7 | Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution显示文摘 | Hiroshi Nagata Yasutada Akiba Hidekazu Suzuki Hideyuki Okano Toshifumi Hibi | 2005 | FEBS Letters2005，，1： | 1 |
| 8 | Chronic ethanol consumption exacerbates microcirculatory damage in rat mesentery after reperfusion显示文摘 | Jing-Yan Han Soichiro Miura Yasutada Akiba | 2001 | Am J Physiol Gastrointest Liver Physiol2001，280，： | 1 |
| 9 | Diversity and seasonal changes in lactic acid bacteria in the intestinal tract of cultured freshwater fish 显示文摘 | Tatsuro Hagi Daichi Tanaka Yasutada Iwamura Takayuki Hoshino | 2004 | Aquaculture2004，234，1： | 1 |
| 10 | Transformation of fibroblast to myofibroblast by application of Hp on the gastric surface epithelial cell using two- layered culture of gastric mucous cell and fibroblast: Its relation to leptin and rebamipide显示文摘 | Masahiko Nakamura Yasutada Akiba Hidenori Matsui and Hiromasa Ishii | 2003 | Gastroenterology2003，124，4： | 1 |
| 11 | Lafutidine, a Protective H 2 Receptor Antagonist, Enhances Mucosal Defense in Rat Esophagus显示文摘 | Yasutada Akiba Jonathan D. Kaunitz | 2010 | Digestive Diseases and Sciences2010，，11： | 1 |
| 12 | Largescale boilover experiments using crude oil显示文摘 | Hiroshi Koseki Yasutada Natsume Yusaku Iwata etal | 2006 | Fire Safety Journal2006，41，7： | 1 |
| 13 | A study on lame-scale boilover using crude oil containing emulsified water显示文摘 | Hiroshi Koseki Yasutada Nastume Yasaku Iwata | 2003 | Fire Safety Journal2003，38，： | 1 |
| 14 | Diversity and seasonal changes in lactic acid bacteria in the intestinal tract of cultured freshwater fish显示文摘 | Tatsuro H Daichi T Yasutada I | 2004 | Aquaculture2004，234，： | 1 |
| 15 | Determination of Ring-OSF Position in Czochralski Silicon Single Crystals by Numerical Analysis of Distribution of Grown-in Defects显示文摘A numerical analysis technique that incorporates Voronkov's model were examined and used to estimate the distribution of defects during crystal growth. By comparisons of the distribution of the density of LSTD and the position of R-OSF in non-nitrogen-doped (non-N-doped) and nitrogen-doped (N-doped) silicon crystals, it is found that the results of the numerical analyses agree with practically evaluated data. The observations suggest that the R-OSF nucleus is a VO2 complex that is formed by bonds between oxygen atoms and residual vacancies consumed during the formation of void defects. This suggests that Voronkov's model can be used to accurately predict the generation and growth of defects in silicon crystals. This numerical analysis technique was also found to be an effective method of estimating the distribution of defects in silicon crystals during crystal growth. | Sunao Abe Takahiro Terada Yasutada Nakagawa Kazuhiko Kashima | 2006 | Journal of Rare Earths2006，24，z1： | 0 |
| 16 | 用于旋翼飞机开发研究的多分野解析框架显示文摘介绍了日本宇宙航空研究开发机构研发的用于旋翼飞机的多分野解析框架。Heli Design是在各种旋翼飞机初期概念设计时使用的软件;rFlight可以提供在各种飞行条件下的平衡解析和线性化飞行模型;rBET/RMT是基于叶片要素理论的低保真度空力解析软件,和rMode提供的结构模型结合,可以推测旋转翼的弹性变形和各种飞行条件下的空力负载;rFlow3D是基于CFD计算的高保真度数值模拟软件;rGrid系列自动网格构造工具为其提供简单的网格生成;基于rFlow3D的计算结果,r Noise可以预测在任何观测点的噪声。这些软件已经广泛地被应用在各种新型旋翼飞机的开发研究中,其计算精度也已被各种实验结果所应证。 | TANABE Yasutada SUGAWARA Hideaki KIMURA Keita | 2024 | Transactions of Nanjing University of Aeronautics and Astronautics2024，41，1： | 0 |
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