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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | 显示文摘 | Linsebigler A Lu G Yates J T | 1995 | Chem Rev1995，95，： | 2 |
| 3 | The biological impact of mass-spectrometry-based proteomics 显示文摘 | Cravatt B F Simon G M Yates J R 3rd | 2007 | Nature2007，450，7172： | 1 |
| 4 | Primary structure of Gamma-bungarotoxin, a new postsynaptic neurotoxin from venom of Bungarus multicinctus 显示文摘 | Aird S D Womble G C Yates J R | 1999 | Toxicon1999，37，4： | 1 |
| 5 | Nutrient require- ment and cycling in energy crops 显示文摘 | Christian D G Riche A B Yates N E | 1997 | Sustainable Agri- culture for Food Energy and Industry1997，2，： | 1 |
| 6 | Canine distemper epizootic in lions,tigers,and leopards in North America显示文摘 | APPEL M J YATES R A FOLEY G L | 1994 | J Vet Diagn Invest1994，6，3： | 1 |
| 7 | Photocatalysis on TiO2 Surfaces: Principles, Mechanisms, and Selected Results 显示文摘 | Linsebigler A L Lu G Yates J T | 1995 | Chemical Reviews1995，95，3： | 1 |
| 8 | Photocatalysis on TiO2 surface: principles, mechanisms and selected results 显示文摘 | Linsebiger A L Lu G Q Yates J T | 1995 | Chem Rev1995，95，： | 1 |
| 9 | Photocatalysis on TiO2 surface:principles,mechanisms and selected results显示文摘 | Linsebigler A L Lu G Q Yates J T | 1995 | Chem Rev1995，95，3： | 1 |
| 10 | Photocatalysis on TiO2Surfaces:Principles,Mechanisms,and Selected Results显示文摘 | LINSEBIGLER A L LU G Q YATES J T | 1995 | Chemical Reviews1995，95，3： | 1 |
| 11 | Analysis of loline alkaloids in endophyte-infected tall fescue by capillary gas chromatography显示文摘 | Yates S G Petroski R J Powell R G | 1990 | Journal of Agriculture and Food Chemistry1990，，38： | 1 |
| 12 | Capacity of interference than nels with partial transmitter cooperation显示文摘 | MARIC RD YATES G KRAMER | 2007 | IEEE Transactions on Information Theory2007，53，35： | 1 |
| 13 | Volatile flavour constituents in the skin oil from Feijoa sellowiana显示文摘 | Shaw G J Allen J M Yates M K | 1989 | Phytochernistry1989，28，5： | 1 |
| 14 | Bistatic SAR image formation显示文摘 | Yates G Home A M Blake A P | 2006 | IET Radar Sonar and Navigation2006，153，3： | 1 |
| 15 | photo-catalysis on TiO2 surfaces: principles, mechanisms, and selected results 显示文摘 | Linsebigler A L Lu G Q Yates JT | 1995 | Chemical Review1995，25，： | 1 |
| 16 | Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis显示文摘 | Basler E Grompe M Parenti G Yates J | 1992 | Am J Hum Genet1992，50，： | 1 |
| 17 | Photocatalysis on TiO2 surfaces: Principles, mechanism, and selected results 显示文摘 | Linsebigler A L Lu G Yate J T | 1995 | Chem Rev1995，95，3： | 1 |
| 18 | Photocatalysis on TiO2 Surface:Principles,Mechanisms and Selected Results显示文摘 | Linsebigler A L Lu G Q Yates J T | 1995 | ChemRev1995，95，3： | 1 |
| 19 | Photocatalysis on TiO2 surfaces:principles,Mechanisms,and selected results显示文摘 | Linsebigler A L Lu G Yates J T | 1995 | Chemical Reviews1995，，95： | 1 |
| 20 | Photochemical activity of nitrogen-doped futile TiO2(110) in visible light显示文摘 | DIWALD O THOMPSON T L ZUBKOV T GORALSKJ E G WALCK S D YATES J T | 2004 | J Phys Chem B2004，108，19： | 1 |
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