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| 1 | Comparison of pre-treatment and post-treatment use of selenium in retinal ischemia reperfusion injury显示文摘AIM: To investigate the effects of selenium in rat retinal ischemia reperfusion(IR) model and compare pretreatment and post-treatment use.METHODS: Selenium pre-treatment group(n =8) was treated with intraperitoneal(i.p.) selenium 0.5 mg/kg for7 d and terminated 24 h after the IR injury. Selenium posttreatment group( n = 8) was treated with i. p. selenium0.5 mg/kg for 7d after the IR injury with termination at the end of the 7d period. Sham group(n =8) received i.p.saline injections identical to the selenium volume for 7d with termination 24 h after the IR injury. Control group(n =8) received no intervention. Main outcome measures were retina superoxide dismutase(SOD), glutathione(GSH),total antioxidant status(TAS), malondialdehyde(MDA),DNA fragmentation levels, and immunohistological apoptosis evaluation.RESULTS: Compared to the Sham group, selenium pre-treatment had a statistical difference in all parameters except SOD. Post-treatment selenium also resulted in statistical differences in all parameters except the MDA levels. When comparing selenium groups, the pre-treatment selenium group had a statistically higher success in reduction of markers of cell damage such as MDA and DNA fragmentation. In contrast, the post-selenium treatment group had resulted in statisticallyhigher levels of GSH. Histologically both selenium groups succeeded to limit retinal thickening and apoptosis. Pre-treatment use was statistically more successful in decreasing apoptosis in ganglion cell layer compared to post-treatment use.CONCLUSION: Selenium was successful in retinal protection in IR injuries. Pre-treatment efficacy was superior in terms of prevention of tissue damage and apoptosis. | Alper Yazici Hasan Aksit Esin Sogutlu Sari Arzu Yay Haydar Ali Erken Dilek Aksit Harun Cakmak Kamil Seyrek Sitki Samet Ermis | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 3 |
| 2 | Protective effects of sildenafil citrate administration on cisplatin-induced ovarian damage in rats显示文摘 | Taskin MI Yay A Adali E Balcioglu E Inceboz U | 2015 | Gynecol Endocrinol2015，31，4： | 1 |
| 3 | Emergency hysterectorny for obstetric hemorrhage显示文摘 | Clark SL Szez YaY Phelan JP | 1984 | Am J Obstet Gynecol1984，64，9： | 1 |
| 4 | Accruals quality and internal control over financial reporting 显示文摘 | Doyle J Ge W Mc Yay S | 2007 | The Accounting Review2007，82，5： | 1 |
| 5 | Multidimensional wavelet design using generalized transformations显示文摘 | Kingsbury N G Yay D B H | 1993 | Applications of Wavelet Transforms in Image Proceedings1993，20，： | 1 |
| 6 | Emissions of organic hazardous air pollutants during Chinese coal combustion 显示文摘 | YAY RONG ZHU HAILING ZHENG CHUGUANG | 2002 | Energy2002，27，5： | 1 |
| 7 | High serum erythropoietin level is associated with smaller infarct size in patients with acute myocardial infarction undergoing successful primary percutaneous coronary intervention显示文摘 | NAMIUCHI S KAGA YAY OHT A J | 2005 | J Am Coll Cardiol2005，45，： | 1 |
| 8 | Reactive oxygen species- induced gastric ulceration: protection by melatonin 显示文摘 | Bandyopadhyay D Chattopa。yay A | 2006 | Curr Med Chem2006，13，10： | 1 |
| 9 | Multivariate statistics to investi- gate metal contamination in surface soil 显示文摘 | Yay O D Alagha O Tuncel G | 2008 | Journal of Environ- mental Management2008，86，： | 1 |
| 10 | Application of full permeate recycling to very high gravity ethanol fermentation from corn 显示文摘 | Ding Zhongyang Zhang Liang Fang Yaye | 2009 | Short Communication2009，26，3： | 1 |
| 11 | Separating the effects of trees on crops:the case ofFaidherbia albida and millet in Niger显示文摘 | Kho RM Yacouba B Yaye M Katkore B Moussa A Iktam A Mayaki A | | 0，，： | 1 |
| 12 | Allopurmol hypersensitivity syndrome and acute myocarction-two case reports 显示文摘 | Chan YC Yay YK Ng SK | 2002 | Ann Acad Med Singapore2002，31，2： | 1 |
| 13 | A Simplified Technique for Shakedown Limit load Determination显示文摘 | Abdalla HF Mohammad MM Maher YAY | 2007 | Nuclear Engineering and Design2007，237，1213： | 1 |
| 14 | Esophageal perforation-the problem s of late presentation显示文摘 | SINGH RK SAH NI P CH ATTOPADH YAY TK | 2008 | H epato-gastroenterology2008，55，88： | 1 |
| 15 | Beta1 integrin signaling maintains human epithelial progenitorcell survival in situ and controls proliferation, apoptosis andmigration of their progeny显示文摘 | Ernst N Yay A Biro T Tiede S Humphries M Paus R KloepperJE | 2013 | PLoS One2013，8，84： | 1 |
| 16 | Proteasome inhibition augments cigarette smoke-induced GM-CSF expression in trophoblast cells via the epidermal growth factor receptor显示文摘 | YaY F Jennifer C Nergard | | 0，，08： | 1 |
| 17 | T e c h n o lo g y ,c a p a b ilitie s ,a n d perform an ce o f low pow er terah ertz so u rces显示文摘 | C h attopad h yay G | 2011 | IE E E T ra n sa ctio n s onTerahertz Scien ce and T ech n ology2011，1，1： | 1 |
| 18 | Allopurinol hypersensitivity syndrome and acute myocardial infarction--two case reports显示文摘 | Chan YC Yay YK Ng SK | 2002 | Ann Acad Med Singapore2002，31，2： | 1 |
| 19 | Clostridium difficile-associated disease in a setting of endemicity:identification of novel risk factors显示文摘 | Dubberke ER Resks KA Yay Y | 2007 | Clin Infect Dis2007，45，12： | 1 |
| 20 | 华南溶洞与地下河 广西瑶族的“水”之史诗显示文摘在地上,中国南方喀斯特是巍峨峰丛、雄奇天坑、壮丽石屏,一条大江从中蜿蜒而过,成就了无数山水画廊、人文风光。在地下,喀斯特还有'私藏':溶洞里石笋、石幔瑰丽奇绝,古老的地下河流淌不息——它们构成了另一个神秘世界。远古时,中国南方还是一片莽莽沧海,日积月累,埋葬了无数海洋生物的骨骼遗骸,垒起万余米碳酸盐岩地层。在后来的一次次地质运动里,深而厚的碳酸盐岩逐渐从海底抬升、露出水面,成为陆地。中国南方气候湿热,降雨丰沛,雨滴、河流以'滴水穿石'之功溶蚀着碳酸盐岩,经年累月,重塑地表。 | 周芳 韦革宁(图) 梁杰(图) yay(图) ccm请叫我小超人(图) 无 | 2021 | 环球人文地理2021，，7： | 0 |
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