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| 1 | 分子标记辅助选择在含辣椒素酯的辣椒新品种选育中的应用显示文摘辣椒素酯类物质是辣椒果实中低辣味的辣椒素类似物。其生物活性与辣椒素类物质相似,有抑制脂肪积累和抗氧化等特性。由于辣椒素酯类物质的辣味低,与辣椒素相比更易于制作食品添加剂。但是辣椒素酯类物质有水不稳定和热不稳定性,其含量随果实的成熟而逐渐降低。所以,含有辣椒素酯的果实适合在成熟之前鲜食。以前的遗传研究表明p-AMT和Pun1两个基因控制辣椒素酯的合成,这两个基因分别表示为A、B。基因型为aa BB和aa Bb的植株果实中含辣椒素酯,辣味较低。本研究在杂交育种中利用p-AMT和Pun1基因的DNA标记选育了一个含有辣椒素酯类物质的辣椒新品种。Murasaki(AAbb)和CH-19 Sweet(aa BB)杂交后代的基因型都用DNA标记进行了鉴定。p-AMT基因型利用d CAPS标记鉴定,Pun1基因型用SCAR标记鉴定。分析杂交后代的基因型,筛选出基因型aa BB或者aa Bb的植株并培育出了一个新品种Maru Salad。Maru Salad果实的辣椒素酯含量为700μg/g DW。同时Maru Salad的果实比CH-19 Sweet大,而且适合鲜食。 | Yoshiyuki Tanaka Hirotsugu Yoneda Munetaka Hosokawa Tetsuya Miwa Susumu Yazawa 马义花 孔秋生 | 2014 | 辣椒杂志2014，，4： | 4 |
| 2 | Non-alcoholic fatty liver and chronic kidney disease:Retrospect,introspect,and prospect显示文摘With the growing prevalence of obesity and diabetes in the United States and across the world,a rise in the overall incidence and prevalence of non-alcoholic fatty liver disease(NAFLD)is expected.The risk factors for NAFLD are also associated with the development of chronic kidney disease(CKD).We review the epidemiology,risk factors,genetics,implications of gut dysbiosis,and specific pathogenic mechanisms linking NAFLD to CKD.Mechanisms such as ectopic lipid accumulation,cellular signaling abnormalities,and the interplay between fructose consumption and uric acid accumulation have led to the emergence of potential therapeutic implications for this patient population.Transplant evaluation in the setting of both NAFLD and CKD is also reviewed.Potential strategies for surveillance and management include the monitoring of comorbidities,the use of non-invasive fibrosis scoring systems,and the measurement of laboratory markers.Lastly,we discuss the management of patients with NAFLD and CKD,from preventative measures to experimental interventions. | Rajiv Heda Masahiko Yazawa Michelle Shi Madhu Bhaskaran Fuad Zain Aloor Paul J Thuluvath Sanjaya K Satapathy | 2021 | World Journal of Gastroenterology2021，27，17： | 3 |
| 3 | Hydrogen-Rich University of Wisconsin Solution Attenuates Renal Cold Ischemia–Reperfusion Injury显示文摘 | Toyofumi Abe Xiao-Kang Li Koji Yazawa Naoyuki Hatayama Lin Xie Bunpei Sato Yoichi Kakuta Koichi Tsutahara Masayoshi Okumi Hidetoshi Tsuda Jun-ya Kaimori Yoshitaka Isaka Michiya Natori Shiro Takahara Norio Nonomura | 2012 | Transplantation Journal2012，，1： | 2 |
| 4 | Do liver metastases from gastric cancer contraindicate aggressive surgical resection?A 14-year single-center experience显示文摘BACKGROUND Advanced gastric cancer(GC)with liver metastasis is often characterized by multiple and bilobular metastases and may also be associated with extrahepatic metastatic lesions.Hence,many physicians consider that radical surgeries are contraindicated for liver metastases from GC(LMGC).According to the 2017 Japanese treatment guideline for GC,a smaller number of liver metastases without unresectable factors may be an indication for liver resection(LR)with curability.The actual 5-year overall survival(OS)rate ranges from 0 to 0.37.AIM To present the institutional indications for LR for LMGC and identify important factors for prognostic outcomes.METHODS In total,30 patients underwent LR for LMGC during a 14-year period,and we evaluated the clinical,surgical,and oncological findings.In all patients,radical surgery with intentional lymphadenectomy was performed for the primary GC.The median follow-up duration after the initial LR was 33.7 mo,and three patients with no recurrence died of causes unrelated to the LMGC.The OS and recurrence-free survival rates after the initial LR were assessed.RESULTS Seventeen patients had metachronous LMGC.The initial LR achieved curability in 29 patients.Perioperative chemotherapy was introduced in 23 patients.The median greatest LMGC dimension was 30 mm,and the median number of LMGC was two.Twenty-two patients had unilobular LMGC.The 5-year OS and recurrence-free survival rates were 0.48 and 0.28,respectively.The median survival duration and recurrence-free duration after the initial LR were 16.8 and 8.6 mo,respectively.Twenty-one patients developed recurrence after the initial LR.Additional surgeries for recurrence were performed in nine patients,and these surgeries clearly prolonged the patients’survival.Pathological serosal invasion was an independent predictor of a poor prognostic outcome after the initial LR.Aggressive LR may be indicated for carefully selected patients with LMGC.CONCLUSION Our results of LR for LMGC seem acceptable.Additional surgeries for recurrence after the initial LR might prolong OS.Pathological serosal invasion is important for poor prognostic outcomes. | Takefumi Yazawa Tomohide Hori Hidekazu Yamamoto Hideki Harada Michihiro Yamamoto MasahiroYamada Masaki Tani Asahi Sato Yasuyuki Kamada Ryotaro Tani Ryuhei Aoyama Yudai Sasaki MasazumiZaima | 2020 | World Journal of Gastrointestinal Pharmacology and Therapeutics2020，11，5： | 2 |
| 5 | Isolation of the gene encoding Carrot leafy cotyledon1 and expression analysis during somatic and zygotic embryogenesis显示文摘 | Katsumi Yazawa Kiminori Takahata Hiroshi Kamada | 2003 | Plant Physiology and Biochemistry2003，，3： | 2 |
| 6 | Nanosized gold clusters formation in selected areas of soda-lime silicate glass 显示文摘 | SHENG J KADONO K YAZAWA T | 2003 | J Non-Cryst Solids2003，324，： | 2 |
| 7 | Development of Ti-Bearing High Performance Ferritic Stainless Steels R430XT and RSX-1显示文摘 | Yazawa Y Kato Y Kobayashi M | 1999 | Kawasaki Steel Technical Report1999，23，： | 1 |
| 8 | Production of eicosapentaenoic acid from marine bacteria 显示文摘 | Yazawa K | 1996 | Lipids1996，31，1： | 1 |
| 9 | Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors显示文摘 | Yazawa K Fujimori M Nakamura T | 2001 | Breast Cancer Res Treat2001，66，2： | 1 |
| 10 | Using induced pluripotent stemcells to investigate cardiac phenotypes in Timothy syndrome 显示文摘 | Yazawa M Hsueh B Jia XL | 2011 | Na-ture2011，471，7337： | 1 |
| 11 | SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients显示文摘 | Shcheglovitov A Shcheglovitova O Yazawa M | 2013 | Nature2013，503，7475： | 1 |
| 12 | Bifidobacterium longum as a delivery system for cancer gene therapy: selective localization and growth in hypoxie tumors 显示文摘 | Yazawa K Fujimori M Amano J | 2006 | Cancer Gene Therapy2006，12，2： | 1 |
| 13 | Association of free fatty acids (FFA) and tumor necrosis factor-alpha (TNF alpha) and insulin resistant meta bolic disorder显示文摘 | Ohmura E Hosaka D Yazawa M Tsuchida A Tokunaga M Ishida H | 2007 | Horm Metah Res2007，39，： | 1 |
| 14 | A novel ex vivo method for assaying adhesion of cancer cells to the peritoneum 显示文摘 | Yazawa S Kudo S | 1994 | Cancer Lett1994，78，13： | 1 |
| 15 | ,Bifidobacterium longum as adelivery system for cancer gene therapy:selective localization and growth in hypoxic tumors显示文摘 | YAZAWA K FUJI mori M AMANO J | 2000 | Cancer Gene Ther2000，7，2： | 1 |
| 16 | Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's disease 显示文摘 | CUI Y LE Y YAZAWA H | 2002 | J Leukoc Biol2002，72，4： | 1 |
| 17 | Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium显示文摘 | Ito T Udaka N Yazawa T | 2000 | Development2000，127，18： | 1 |
| 18 | Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome显示文摘 | Yazawa M Hsueh B Jia X | | 0，，7337： | 1 |
| 19 | Long tract degeneration in familial sudanophilie leukodystrophy with prominent spheroids 显示文摘 | Yazawa I Nakano I Yamada H | 1997 | J NcurolSei1997，147，2： | 1 |
| 20 | Alveolar soft part sarcoma in Japan: multi-institutional study of 57 patients from the Japanese Musculoskcletal Oncology Group 显示文摘 | Ogose A Yazawa Y Ueda T | 2003 | Oncology2003，65，1： | 1 |
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