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| 1 | Comparison of Transformation Efficiency of piggyBac Transposon among Three Different Silkworm Bombyx mori Strains显示文摘在由编码 transposase 定序的小猪用绳子拖的平底渡船向量和助手 plasmidcontaining 的混合物的微注射编码基因进蚕鸡蛋的提高的绿荧光蛋白质(EGFP ) 的介绍以后比较的蚕 Bombyx moriwas 的三不同紧张的转变率。尽管在在在微注射鸡蛋(P=0.1258 ) 的肥沃的蛾的百分比的三紧张之中没有重要差别, G0 的百分比转变了在肥沃的蛾和注射鸡蛋的蛾两个都是显著地不同的(P=0.01368 和 P=0.02398,分别地) 。Nistari 紧张(印度紧张) 的转变率比另外的二紧张, Golden-yellow-cocoon (Vietnamesestrain ) 和 Jiaqiu (中国紧张) 的显著地高,它有类似的率。这些结果显示基于 piggyBac 的系统的转变效率可能与不同基因背景与蚕紧张变化。内长的象 piggyBac 一样元素的存在可能是影响介绍 piggyBac-derivedvectors,和多样的数量的转变效率的一个重要因素,在不同的蚕紧张的激活可能说明重要差别。 | Boxiong ZHONG~1 Jianying LI~1 Jin’e CHEN~(1,2) Jian YE~1 and Songdong YU~1 ~1College of Animal Sciences,Zhejiang University,Hangzhou 310029,China ~2Institute of Sericultural Research,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，2： | 17 |
| 2 | Persistence of hepatitis B vaccine immune protection and response to hepatitis B booster immunization显示文摘AbstractAIMToidentifythepersistenceofimmuneprotectionofChinamade,plasmaderivedhepatitisBvaccineafterinfancyimmunizationandt... | LI Hui 1, LI Rong Cheng 2, LIAO Su Su 1, YANG Jin Ye 2, ZENG Xian Jia 1 and WANG Shu Sheng 2 | 1998 | World Journal of Gastroenterology1998，4，6： | 15 |
| 3 | Analysis of the contribution of acid phosphatase to P efficiency in Brassica napus under low phosphorus conditions显示文摘To understand whether genotypic variation in acid phosphatase (APase) activity in rapeseed (Brassica napus L.) induced by phosphorus (P) deficiency has impact on P efficiency,soil APase activity in the rhizosphere for rapeseed P-efficient genotype 102 and P-inefficient genotype 105 was measured against organic and inorganic P sources in the pot experiment,and the activities of root-secreted APase and leaf intracellular APase were investigated in different P-starvation periods in the nutrient solution.Higher activity of root-secreted APase in B.napus was induced under low P conditions.However,P nutrition and P uptake efficiency of the plants supplied with organic P were not directly related to the activity of root-secreted APase due to several confounding factors affecting APase availability.The higher activity of leaf APase improved P remobilization in plants and played important roles in enhancing P use efficiency,shown by the significant correlation between leaf APase activity and P use efficiency in a rapeseed recombinant inbred population of 135 lines. | ZHANG HaiWei1,2,HUANG Yu2,YE XiangSheng2 & XU FangSen1,2 1 National Key Laboratory of Crop Genetic Improvement,Huazhong Agricultural University,Wuhan 430070,China 2 Key Laboratory of Subtropical Agriculture and Environment,Ministry of Agriculture,Huazhong Agricultural University,Wuhan 430070,China | 2010 | Science China(Life Sciences)2010，53，6： | 13 |
| 4 | Diet and gastric cancer:a case-control study in Fujian Province,China显示文摘NTRODUCTIONChangleandFuqingcitiesarelocatedinthesoutheasternpartofFujianProvince,Chinawithahighincidenceofgastriccancer.Howev... | YE Wei Min 1, YI Ying Nan 1, LUO Ren Xia 2, ZHOU Tian Shu 3, LIN Ru Tao 1 and CHEN Gui Dong 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 12 |
| 5 | Plasma D(-)-lactate as a new marker for diagnosis of acute intestinal injury following ischemia-reperfusion显示文摘PlasmaD()lactateasanewmarkerfordiagnosisofacuteintestinalinjuryfolowingischemiareperfusionYAOYongMing1,YUYan1,WUYe2,LUL... | YAO YongMing1, YU Yan1, WU Ye2, LU LianRong1 and SHENG ZhiYong1 | 1997 | World Journal of Gastroenterology1997，3，4： | 12 |
| 6 | Clinicopathological and molecular genetic analysis of 4 typical Chinese HNPCC families显示文摘AIM: To study the clinicopathological and molecular genetic characteristics of typical Chinese hereditary nonpolyposis cotorectal cancer (HNPCC) families.METHODS: Four typical Chinese HNPCC families were analyzed using microdissection, microsatellite instability analysis, immunostaining of hMSH2 and hMLH1 proteins and direct DNA sequencing of hMSH2 and hMLH1 genes.RESULTS: All five tumor tissues of 4 probands from the 4typical Chinese HNPCC families showed microsatellite instability at more than two loci (MSI-H or RER +phenotype). Three out of the 4 cases lost hMSH2 protein expression and the other case showed no hMLH1 protein expression. Three pathological germline mutations (2 in hMSH2 and 1 in hMLH1 ), which had not been reported previously, were identified. The same mutations were also found in otler affected members of two HNPCC families,respectively.CONCLUSION: Typical Chinese HNPCC families showed relatively frequent germline mutation of mismstch repair genes. High-level microsateliita instability and loss of expression of mismatch repair genes correlated closely with germline mutation of mismatch repair genes. Microsatellite instability analysis and immunostaining of miamstch repair gens might serve as effective screening methods before direct DNA sequencing. It is necessary to establish clinical criteria and molecular diagnostic strategies more suitable for Chinese HNPCC families. | Qi Cai~1 Meng-Hong Sun~1 Hong-Fen Lu~1 Tai-Ming Zhang~1 Shan-Jing Mo~2 Ye Xu~2 San-Jun Cai~2 Xiong-Zeng Zhu~1 Da-Ren Shi~1 1 Department of Pathology2 Department of Abdominal Surgery,Cancer Hospital/Cancer Institute,Fudan University,Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，6： | 10 |
| 7 | Physical analysis and numerical simulation for the dynamic behaviour of vehicles in pitching oscillations or rocking motions显示文摘Analytical methods of nonlinear dynamics and numerical simulations for the cou-pling equations of Navier-Stokes and flight mechanics are used to study the dynamic behaviour of pitching motions of reentry capsules with the variation of Mach number, and rocking motions of swept wings with the variation of angle of attack. Conditions under which the dynamic instability, Hopf bifurcation and saddle-node bifurcation occur are obtained. The node-saddle-node topological structure in the phase portrait, i.e. the state of bi-attractors (attracting basins) is described. The evolving process of dynamic behaviour and flow fields are given. The theories are compared with some numerical simulations conducted by the authors. Besides, some verifiable experi-mental results are cited. The agreement between them is very well. | ZHANG HanXin1,2,3, ZHANG Zhao1,3, YUAN XianXu1,2, LIU Wei1, XIE YuFei1,2 & YE YouDa1,2 1 China Aerodynamics Research and Development Center, Mianyang 621000, China 2 National Laboratory for Computational Fluid Dynamics, Beijing University of Aeronautics and Astronautics, Beijing 100083, China 3 School of Aerospace, Tsinghua University, Beijing 100084, China | 2007 | Science China(Technological Sciences)2007，50，4： | 10 |
| 8 | Long-term eficacy of plasma-derived hepatitis B vaccine among Chinese children:a 12-year folow-up study显示文摘INTRODUCTIONToevaluatelongtermeficacyofaplasmaderivedhepatitisBvaccineandprovideevidencefordecisionmakingonthevaccineboost... | LIAO Su Su 1, LI Rong Cheng 2, LI Hui 1, YANG Jin Ye 2, ZENG Xian Jia 1, GONG Jian 2, WANG Shu Sheng 2, LI Yan Ping 2 and ZHANG Kong Lai 1 | 1999 | World Journal of Gastroenterology1999，5，2： | 9 |
| 9 | Influence of L-methionine-deprived total parenteral nutrition with 5-fluorouracil on gastric cancer and host metabolism显示文摘AIM To investigate the influence of L-methioninedeprived total parentaral nutrition with 5-FU on gastric cancer and host metabolism.``METHODS N-methyI-N-nitro-nitrosoguanidine ( MNNG )induced gastric cancer rats were randomly divided into four groups: Met-containing TPN group (n= 11 ), Metdeprived TPN group (n = 12), Met-containing TPN + 5-FU group (n = 11) and Met-deprived TPN + 5-FU group (n-12). Five rats in each group were sacrificed after 7days of treatment and the samples were taken for examination. The remaining rats in each group were then fed separately with normal diet after the treatment until death, the life span was noted.``RESULTS The tumors were enlarged in Met-containing group and shrank in Met-deprived group markedly after the treatment. The DNA index (DI) of tumor cells and the body weight (BW) of rats had no significant change in the two groups, however, the ratio of tumor cells' S phase was increased The ratio of G2M phase went up in Metcontaining group, but down in Met-deprived group. In the other two groups that 5-FU was added, the BW of rats,and the diameter of tumors, the DI of tumor cells, the S and G2M phase ratio of tumor cells were all decreased,particularly in Met-deprived plus 5-FU group. Pathological examination revealed that the necrotic foci of the tumor tissue increased after Met-deprived TPN treatment, and the nucleoli of tumor cells enlarged. In -MetTPN + 5-FUgroup, severe nuclear damage was also found by karyopyknosis and karyorrhexis, meanwhile there was slight degeneration in some liver and kidney cells. The serum free Met and Cysteine decreased markedly (P<0.001), while other amino acids, such as serum free serine and glutamine increased significantly ( P< 0.005).All the rats died of multiple organ failure caused by cancer metastasis. The average survival time was 18.6 days in Met-containing TPN group. 31 days in Met-deprived TPN group, 27.5 days in Met-containing TPN + 5-FU group, and 43 days in Met-deprived TPN+ 5-FU group (P<0.05).``CONCLUSION Met-deprived TPN causes methionine starvation of tumor cells, and can enhance the anti-tumor effect of 5-FU and prolong the life span of gastric cancerbearing rats. | Hong-Bing Xiao~1 Wei-Xin Cao~2 Hao-Ran Yin~2 Yan-Zhen Lin~2 Shi-Hui Ye~1 1 Department of Surgery,Affiliated Railway Hospital,Tongji University,Shanghai 200072,China2 Department of Surgery,Affiliated Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2001 | World Journal of Gastroenterology2001，7，5： | 9 |
| 10 | Characteristics of landscape information Tupu of the Yellow River swings and its subdeltas during 1855―2000显示文摘Based on the theories and methods of cartography on spatial pattern and temporal evolution in Geo-information Tupu (Carto-methodology in Geo-information, CMGI) and the quantitative measurements of pattern and process in landscape ecology, the methodology of landscape information Tupu in studying the swing process of the Yellow River (YR) over the Yellow River Delta (YRD) during 1855― 2000 has been demonstrated. The main content includes: (1) methodology of landscape information Tupu; (2) evolution process Tupu of YR rump channels; (3) evolution process Tupu of the 7 pieces of subdeltas in YRD during 1855―2000; (4) landscape information Tupu of the modern YRD and the current YRD; (5) landscape information Tupu of YR rump channels on the 7 pieces of subdeltas during 1855―2000; and (6) corridor-matrix landscape information Tupu by YR swings. The methodology of landscape information Tupu here is still primary but we hope that it could provide a new tool for exploring an integrated research on spatiotemporal approaches for landscape 'pattern and process'. | YE QingHua1,3?, CHEN ShenLiang2, HUANG Chong4, XUE YunChuan5, TIAN GuoLiang3, CHEN ShuPeng3,4, SHI YaNan4, LIU QingSheng4 & LIU GaoHuan4 1 Institute of Tibetan Plateau Research (ITPR), Chinese Academy of Sciences (CAS), Beijing 100085, China 2 State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai 200062, China 3 State Key Laboratory of Remote Sensing Science, Institute of Remote Sensing Applications (IRSA), CAS, Beijing 100101, China 4 Institute of Geographic Sciences and Natural Resources Research, CAS, Beijing 100101, China 5 Qingdao Meteorological Bureau, Qingdao 266003, China | 2007 | Science China Earth Sciences2007，50，10： | 8 |
| 11 | VEGF-specific siRNAs modified with 2′-deoxy effectively suppress VEGF expression and inhibit growth of nasopharyngeal carcinoma xenograft in a mouse model显示文摘Vascular endothelial growth factor (VEGF) is up-regulated in the vast majority of human tumors. The up-regulation of VEGF not only plays important roles in tumor angiogenesis, but also provides a target for tumor treatment with small interfering RNA (siRNA) that targets VEGF; however, it is unclear whether a quite high up-regulation of VEGF will affect the efficiency of RNA interference strategies targeting VEGF. A high level expression of VEGF was found in CNE cells from a nasopharyngeal carcinoma cell line. In this study, we investigate whether VEGF-specific siRNAs can effectively suppress VEGF expression in CNE cells, and study the methods for the use of VEGF-specific siRNAs as potential therapeutic agents. CNE cells with high VEGF expression induced by hypoxia were transfected with VEGF-specific siRNAs. The expression of VEGF was effectively suppressed by VEGF-specific siRNAs, measured by ELISA, Western blot analysis and RT-PCR. Furthermore, experiments in nude mice bearing nasopharyngeal carcinoma xenograft were initiated 5 d after injection of CNE cells. VEGF-specific siRNAs were modified with 2′-deoxy, then injected into the tumors, and a liposome-mediated siRNA transfection system and ultrasound exposure were used to help delivery of the siRNAs. Tumor growth was reduced significantly after 3 weeks' treatment. These studies suggest that VEGF-specific siRNAs still can effectively suppress VEGF expression even in tumor cell lines with a relatively high level of VEGF expression, such as CNE, and VEGF-specific siRNAs modified with 2′-deoxy can be used as potential agents for tumor therapy. | CHEN ShanYi1, GAO GuoFeng1, CHEN Wei1, Lü Qing2, TANG Shen2, HUA Zhong2, YE WenBin2, GU DaYong2, WANG ShaYan1 & ZHANG YaOu2 1 Shenzhen People’s Hospital, Clinical Medical College of Jinan University, Shenzhen 518020, China 2 Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China | 2008 | Science China(Life Sciences)2008，51，2： | 6 |
| 12 | TWO-DIMENSIONAL SEDIMENT MATHEMATICAL MODEL FORUNSTEADY FLOW IN THE LOWER YELLOW RIVER显示文摘The theoretical frame of a new two-dimensional sediment mathematical model is established on the basis of the resent research achievements about the sediment transport law of the Yellow River. The formulas of sediment carrying capacity of flow and river roughness, which reflect the features of the Yellow River, are applied to it. The finite element scheme is employed to deduce the discretized equations of the model. The pre-estimated-verified substitution is used to solve them. Verifications of the model are carried out with the flood occurring on Jinan reach of the Yellow River during the flood season in 1976. The calculation results with the model are in good agreement with the measured data. | ZHANG Hongwu LI Dongfeng XU Yuxin ZHANG Junhua (1 Project (No. 39890200) Supported by the National Nature Science Foundation Commission and the Ministry of Water Conservancy 2 Yellow River Institute of Hydraulic Research, Zhengzhou 450003, China 3 Ye | 1999 | International Journal of Sediment Research1999，14，2： | 5 |
| 13 | Hydrothermal Synthesis and Characterization of a Novel Supramolecular Network Compound [Co(IN)_2(H_2O)_4](IN=Isonicotinate)显示文摘A novel supramolecular compound, [Co(IN)2(H2O)4](1), was synthesized by means of the hydrothermal method and its structure was characterized with elemental analysis, FT-IR spectrum, TGA and X-ray diffraction. Though the unit cell structure of the title compound is only monomeric, all these units as building blocks are assembled into a novel three-dimensional supramolecular network via the widely hydrogen-bonding and π-π stacking interactions. | JIA Hong-bin 1,3, YU Jie-hui 1, DING Hong 1, XU Ji-qing 1**, YE Ling 2, JING Wei-jie 1WANG Tie-gang 1, XU Jia-ning 1, QU Xue-jian 1 and LI Zeng-chun 1,31. College of Chemistry and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130023, P. R. China 2. Key Laboratory of Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130023, P. R. China 3. Department of Chemistry, Inner Mongolia University for Nationalities, Tongliao 028000, P. R. China | 2002 | Chemical Research in Chinese Universities2002，18，4： | 5 |
| 14 | Important progress on the use of isotope techniques and methods in catchment hydrology显示文摘The use of isotope techniques and methods in catchment hydrology in the last 50 years has generated two major types of progress: (1) Assessment of the temporal variations of the major stocks and flows of water in catchments, from which the estimation of wa-ter residence times is introduced in this paper. (2) Assessment of catchment hydrologic processes, in which the interactions be-tween different waters, hydrographical separation, and bio-geochemical process are described by using isotopes tracers. Future progress on isotope techniques and methods in hydrology is toward the understanding of the hydrological process in large river basins. Much potential also waits realization in terms of how isotope information may be used to calibrate and test distributed rainfall-runoff models and regarding aid in the quantification of sustainable water resources management. | JinKui Wu 1,2, YongJian Ding 1, BaiSheng Ye 1, QiYue Yang 3, Zhi Wei 1 1. Key Laboratory of Ecological Hydrology and Basin Sciences in Cold and Arid Regions Environmental and Engineering Re-search Institute, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China. 2. Institute for Landscape Ecology and Resources Management, Justus-Liebig-University Giessen, Giessen 35392, Germany. 3. College of Earth and Environmental Science, Lanzhou University, Lanzhou, Gansu 730000, China. | 2009 | Research in Cold and Arid Regions2009，1，3： | 4 |
| 15 | An evaluation of mercury emissions from the chlor-alkali industry in China显示文摘The present status and the history of chlor alkali industry using mercury as cathode in China has been studied. Quantitative mercury emission has been estimated. At present, 17.5%—20% of the consumed mercury is released into water, 49.1%—53.3% of the Hg is discharged to the brine system outside the plants. 10%—14% of the Hg is emitted directly to the atmosphere, 5 3%—6 7% enters waste materials. The chlor alkali industry in China discharged about 17 tons every year. The total amount of mercury released by the chlor alkali industry in China is estimated to be 1400—2700 tons since 50’s. With the result of improved technology and more strict environmental regulations started in late 1970’s, chlorine plants reduced their mercury loss factor from 0 5? ? 4 kg/t NaOH before 1977 to 0.16—0.18 kg/t NaOH in 1997. The number of mercury cells in alkali plants was also reduced. In 1998, China is planning to finish the history of producing chlorine and caustic soda using the mercury cell process in the near future. How to deal with the emitted mercury will remain a main problem. | QI Xiao\|fan 1, LIN Yu\|huan\+1, CHEN Jian\|hua\+1, YE You\|zhong 2 (1. Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China 2. China National Chemical Information Center, Beijing 100029, China) | 2000 | Journal of Environmental Sciences2000，12，S1： | 4 |
| 16 | Changes of lipid metabolism in plasma,liver and bile during cholesterol gallstone formation in rabbit model显示文摘Changesoflipidmetabolisminplasma,liverandbileduringcholesterolgalstoneformationinrabbitmodelZHAOJiChunXIAOLuJia1,ZHUHong2,... | ZHAO JiChun1, XIAO LuJia1, ZHU Hong2, SHU Ye1 and CHENG NanSheng1Keywords cholelithiasis lipids/metabolism cholesterol/metabolism apolipoproteins/metabolism triglycerides/metabolism rabbits diseases models, animal | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 17 | Bayesian networks precipitation model based on hidden Markov analysis and its application显示文摘Surface precipitation estimation is very important in hydrologic forecast. To account for the influence of the neighbors on the precipitation of an arbitrary grid in the network, Bayesian networks and Markov random field were adopted to estimate surface precipitation. Spherical coordinates and the expectation-maximization (EM) algorithm were used for region interpolation, and for estimation of the precipitation of arbitrary point in the region. Surface precipitation estimation of seven precipitation stations in Qinghai Lake region was performed. By comparing with other surface precipitation methods such as Thiessen polygon method, distance weighted mean method and arithmetic mean method, it is shown that the proposed method can judge the relationship of precipitation among different points in the area under complicated circumstances and the simulation results are more accurate and rational. | WANG HongRui1, YE LeTian2, XU XinYi1, FENG QiLei3, JIANG Yan1, LIU Qiong1 & TANG Qi1 1 College of Water Sciences, Key Laboratory for Water and Sediment Sciences of Ministry of Education, Beijing Normal University, Beijing 100875, China 2 School of Mathematical Sciences, Peking University, Beijing 100871, China 3 School of Science, Beijing Institute of Education, Beijing 100011, China | 2010 | Science China(Technological Sciences)2010，53，2： | 4 |
| 18 | The influence of interface exchange coupling on the demagnetization process for perpendicularly oriented FePt/α-Fe/FePt trilayers显示文摘The influence of the interface exchange coupling on the magnetization reversal process for a FePt/α-Fe/FePt tri-layer structure has been studied through a micromagnetic approach.The analytical formula of the nucleation field has been derived.It is found that the nucleation field increases as the interface coupling constant rises.Especially when the thickness of the soft layer is small,the influence of the exchange coupling on the nucleation field is significant.The angular distributions of the magnetization for various exchange coupling constants have been obtained by numerical calculation.It is found that the angular distribution of the magnetization is discontinuous at the interface of the hard and soft layers.In the meantime,the pinning field decreases with the increase of the thickness of the soft layer and the exchange coupling constant. | BO Niao1,ZHAO GuoPing1,2*,YE LinNing3,XU JinSong1 & DENG Ya1 1 College of Physics and Electronic Engineering,Sichuan Normal University,Chengdu 610068,China 2 State Key Laboratory of Electronic Thin Films and Integrated Devices,University of Electronic Science and Technology of China,Chengdu 610054,China 3 School of Economic Information Engineering,Southwestern University of Finance and Economics,Chengdu 610074,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，10： | 4 |
| 19 | Analysis of the cause of crack in cold rolling of QSn6.5-0.1 strip显示文摘In order to know the cause of cracks in cold rolling of QSn6.5 0.1 copper alloy strip, a lot of experiments and analysis were done. The microstructure changes of QSn6.5 0.1 were investigated by means of metallurgical microscope. The morphology of cracks and surface defects were examined using scanning electron microscope. Macroscopic residual stresses produced in every process during manufacturing in the QSn6.5 0.1 strip were measured by X ray diffraction method and hole drilling method. The results show that the cracks in the QSn6.5 0.1 cold rolling strip were caused due to the derivation of metallurgical defects, such as SnO 2, S, fine looses,the inverse segregation unable to clear up when milling, and the accumulation of all kinds of resi dual stresses. When the accumulation of the residual stress reaches the material′s breaking strength, the cracks will be generated. Several measures to avoid the development of these kinds of cracks were put forward, such as: controlling the casting technology, improving homogenization annealing procedure (680 ℃/7 h) and milling quality(using the second milling when necessary), working out a more reasonable rolling technology to ensure intermediate annealing in time. | ZHANG Sheng hua 1,QIN Ye xia 1,LOU Hua fen 2,LU Jun pan 2,ZHONG Wei jia 2 (1 Department of Materials Science and Engineering, Central South University, Changsha 410083, China 2.Luoyang Copper Processing Company, Luoyang 471000, China) | 2001 | Journal of Central South University of Technology2001，8，2： | 3 |
| 20 | The antibody preparation and expression of human Pescadillo显示文摘To explore the biological roles of human Pescadillo and investigate its potential effect on tumorigene- sis, the cDNA of Pescadillo was fused with that of GST. After purification and elution, the purified GST-Pescadillo fusion protein was obtained, and the antibody against the fusion protein was generated. Endogenous Pescadillo protein was observed to be remarkably induced by estrogen. It was mainly distributed in the tissues such as breast, ovary and intestine, all of which contain proliferating cells, and was also detected in many cell lines of human cancer: renal carcinoma, hepatoma, ovarian cancer, colon carcinoma, and breast cancer. The expression level of Pescadillo was increased significantly in breast cancer tissues compared with their paired margin tissues. Taken together, these data suggest that Pescadillo may play important roles in the initiation and development of cancer and may be a po- tential target in cancer diagnosis and therapy. | ZHANG Hao1, LI JiePing1, WANG XiaoHui1, SUN Yan1, YUAN Bin1, YANG ZhiHong1, JIANG YanChao1, ZENG Min1, DING LiHua1, NING Kang1, ZHU JianHua2, LI JieZhi1, HUANG CuiFen1, LIU AiJun3 & YE QiNong1 1 Beijing Institute of Biotechnology, Beijing 100850, China 2 Cancer Division, First Affiliated Hospital of the General Hospital of PLA, Beijing 100373, China 3 Pathology Division, General Hospital of PLA, Beijing 100373, China | 2007 | Science China(Life Sciences)2007，50，3： | 3 |
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