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| 1 | DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress显示文摘DL3-n-Butylphthalide(DLNBP),a small molecular compound extracted from the seeds of Ap/um graveo/ens Linn(Chinese celery),has been shown to exert neuroprotective effects due to its anti-inflammatory,anti-oxidative and anti-apoptotic activities.DL-NBP not only protects against ischemic cerebral injury,but also ameliorates vascular cognitive impairment in dementia patients including AD and PD.In the current study,we investigated whether and how DL-NBP exerted a neuroprotective effect against diabetes-associated cognitive decline(DACD)in db/db mice,a model of type-2 diabetes,db/db mice were orally administered DL-NBP(20,60,120 mg·kg^(-1)·d^(-1))for 8 weeks.Then the mice were subjected to behavioral test,their brain tissue was collected for morphological and biochemical analyses.We showed that oral administration of DL-NBP significantly ameliorated the cognitive decline with improved learning and memory function in Morris water maze testing.Furthermore,DL-NBP administration attenuated diabetes-induced morphological alterations and increased neuronal survival and restored the levels of synaptic protein PSD95,synaptophysin and synapsin-1 as well as dendritic density in the hippocampus,especially at a dose of 60 mg/kg.Moreover,we revealed that DL-NBP administration suppressed oxidative stress by upregulating Nrf2/HO-1 signaling,and increased brain-derived neurotrophic factor(BDNF)expression by activating PI3K/Akt/CREB signaling in the hippocampus.These beneficial effects of DL-NBP were observed in high glucose-treated PC12 cells.Our results suggest that DL-NBP may be a potential pharmacologic agent for the treatment of DACD. | Bei-ni Wang Cheng-biao Wu Zi-miao Chen Pei-pei Zheng Ya-qian Liu Jun Xiong Jing-yu Xu Pei-feng Li Abdullah Al Mamun Li-bing Ye Zhi-long Zheng Yan-qing Wu Jian Xiao Jian Wang | 2021 | Acta Pharmacologica Sinica2021，42，3： | 11 |
| 2 | Review of hybrid electric powered aircraft,its conceptual design and energy management methodologies显示文摘The paper overviews the state-of-art of aircraft powered by hybrid electric propulsion systems.The research status of the design and energy management of hybrid aircraft and hybrid propulsion systems are further reviewed.The first contribution of the review is to demonstrate that,in the context of relatively underdeveloped electrical storage technologies,the study of mid-scale hybrid aircraft can contribute the most to both theoretical and practical knowledge.Meanwhile,the profits and potential drawbacks of applying hybrid propulsion to mid-scale hybrid airplanes have not been thoroughly illustrated.Secondly,as summed in the overview of design methodologies,the multi-objective optimization transcends the single-objective one.The potential of the hybrid propulsion system can be thoroughly evaluated in only one optimization run,if several objectives optimized simultaneously.Yet there are few researches covering the conceptual design of hybrid aircraft using multi-objective optimization.The review of the most popular energy management strategies discloses the third research gap—current methodologies favoured in hybrid ground vehicles do not consider the aircraft safety.Additionally,both non-causal and causal energy management are needed for performing a complicated flight mission with several sub-tasks. | Ye XIE Al SAVVARISAL Antonios TSOURDOS Dan ZHANG Jason GU | 2021 | Chinese Journal of Aeronautics2021，34，4： | 5 |
| 3 | MicroRNA Regulation of Intestinal Epithelial Tight Junction Permeability显示文摘 | Dongmei Ye Shuhong Guo Rana Al–Sadi Thomas Y. Ma | 2011 | Gastroenterology2011，，4： | 3 |
| 4 | Determination of metformin in diabetic rat plasma by an improved ion-pair high- performance liquid chromatography: application to a pharma- cokineticstudy显示文摘 | Chen Ye Li HanQing Xu JiaoJiao et aL | 2012 | J ChinPharmSci2012，21，3： | 1 |
| 5 | Laparoscopic splenectomy and azygoportal disconnection for bleeding varices with hypersplenism 显示文摘 | Wang Y D Ye H Ye Z Y el al | 2008 | J Laparoendosc Adv Surg Tech A2008，18，： | 1 |
| 6 | FHL family members suppress vascu-lar endothelial growth factor expression through blockade 显示文摘 | Lin J Qin X Ye Q ei al | 2012 | IUBMB Life2012，64，11： | 1 |
| 7 | Pscudoephedrine/ephed- rine shows potent anti - inflammatory activity against TNF - ct - media- ted acute liver failure induced by lipopolysaccharide/D - galactosamine 显示文摘 | Zhongping Wu Jin Ye Tong Zhang ct al | 2014 | European journal of pharmacology2014，，： | 1 |
| 8 | Qiliqiangxin inhibits the developmentof cardiac hypertrophy, remodeling,and dysfunction during 4weeks of pressure overload in mice显示文摘 | Zou Y Lin L Ye Y ef al | 2012 | J Cardiovasc Pharma-col2012，59，3： | 1 |
| 9 | MALT lymphoma with t( 14 ;18) ( q32 ; q21 )/IGH-MALTl is characterized by strong cytoplas-mic MALT1 and BCL10 expression显示文摘 | Ye H T Gong L P Liu H X al | 2005 | J Pathol2005，205，3： | 1 |
| 10 | Interleukin-12 inhibits eotaxin secretion of cultured primary lung cells and allevitaes airway inflammation in vivo显示文摘 | Ye YL Huang WC Lee YL el al | 2002 | Cytokine2002，19，2： | 1 |
| 11 | Spatial analysis for spring bloomand nutrient limitation in Xiangxi Bay of Three Gorges Reservoir显示文摘 | Ye L Han X Q Xu Y Y ef al | 2007 | Environmental Monitoring and Assessment2007，127，13： | 1 |
| 12 | JWA as a functional molecule to regulate cancer cell migration via MAPK cascades and F actin cytoskeleton显示文摘 | Chen H Bai J Ye J ct al | 2007 | Cell Signal2007，19，6： | 1 |
| 13 | Antimicrobial susceptibility of Myco and molecular analysis of macrolide-resistant strains from Shanghai, China 显示文摘 | Liu Y Ye X Zhang H et plasma pneumoniae isolates al | 2009 | Antimicrob Agents Chemother2009，53，： | 1 |
| 14 | Evaluation of low-cost cathodecatalysts for high yield biohydrogen production in microbial electrol-ysis cell显示文摘 | Wang L Y’Chen Y W Ye Y J e( al | 2011 | Water Science and Technology2011，63，3： | 1 |
| 15 | Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner显示文摘 | Ferri AL Lin W Mavromatakis YE | 2007 | Development2007，134，15： | 1 |
| 16 | Engineering the provitamin a betacarotene biosynthetic pathway into carotenoid-free rice endosperm显示文摘 | Ye X Al Babili S Kloeti A | 2000 | Science2000，5451，287： | 1 |
| 17 | Pneumonei infection显示文摘 | Ye P Garvey P Huang D et aL IL-17 increases lung immunity and improves lung host defense against K | 1999 | Am J Respir Crit Care Med1999，1，： | 1 |
| 18 | Factors influencing the subjec-tive well being(SWB) in a sample of older adults in an economical-ly depressed area of China 显示文摘 | Zhang JP Huang HS Ye al | 2008 | Arch Gerontol Geriatr2008，46，3： | 1 |
| 19 | Simultaneous quantification of five major bioactive flavonoids in Rhizoma Smilacis Glahrae hy high performance liquid chromatography 显示文摘 | CHEN Liang YIN Ye Y1 Hongwei el al | 2002 | J Pharmaceut Biomed Anal2002，43，17： | 1 |
| 20 | Biochemical显示文摘 | YU JQ YE SF ZHANG MF et aL Effects of root exudates and aqueous root extracts of cucumber ( Cucumis sativus) and allelo- chemicals on photosynthesis and antioxidant enzymes in cucum- ber | 2003 | Systematics and Ecology2003，31，： | 1 |
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