| 3 | Cell models with inducible oncogenic translocations allow to evaluate the potential of drugs to favor secondary translocations显示文摘Dear Editor,Chromosomal translocations result from the interchange of geneticmaterial between non-homologous chromosomes.Chromosomal translocations are formed by erroneous repair of double-stranded breaks(DSBs)via non-homologous end joining(NHEJ)[1].Some genotoxic drugs produce DSBs and thus present a major risk factor for the development of oncogenic chromosomal translocations.The risk factors that interfere with translocationprone DSB repair,once DSBs are already formed,are obscure,and potential effects of drugs on translocation formation during this step have never been explored. | Anna Shmakova Nikolai Lomov Vladimir Viushkov Tatyana Tsfasman Yana Kozhevnikova Darina Sokolova Vadim Pokrovsky Marina Syrkina Diego Germini Mikhail Rubtsov Yegor Vassetzky | 2023 | Cancer Communications2023，43，1： | 0 |
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