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| 1 | Gastric precancerous lesions are associated with gene variants in Helicobacter pylori -susceptible ethnic Malays显示文摘AIM: To identify genes associated with gastric pre-cancerous lesions in Helicobacter pylori (H. pylori )susceptible ethnic Malays. METHODS: Twenty-three Malay subjects with H. pylori infection and gastric precancerous lesions identified during endoscopy were included as 'cases'. Thirtyseven Malay subjects who were H. pylori negative and had no precancerous lesions were included as 'controls'. Venous blood was collected for genotyping with Affymetrix 50K Xba1 kit. Genotypes with call rates < 90% for autosomal single nucleotide polymorphisms (SNPs) were excluded. For each precancerous lesion, associated SNPs were identified from Manhattan plots, and only SNPs with a χ2 P value < 0.05 and Hardy Weinberg Equilibrium P value > 0.5 was considered as significant markers. RESULTS: Of the 23 H. pylori -positive subjects recruited, one sample was excluded from further analysis due to a low genotyping call rate. Of the 22 H. pylori positive samples, atrophic gastritis only was present in 50.0%, complete intestinal metaplasia was present in 18.25%, both incomplete intestinal metaplasia and dysplasia was present in 22.7%, and dysplasia only was present in 9.1%. SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively. Allele frequencies in 'cases' vs 'controls' for rs9315542, rs6878265, rs1042194 and rs10505799 were 0.4 vs 0.06, 0.6 vs 0.01, 0.6 vs 0.01 and 0.5 vs 0.02, respectively. CONCLUSION: Genetic variants possibly related to gastric precancerous lesions in ethnic Malays susceptible to H. pylori infection were identified for testing in subsequent trials. | Sathiya Maran Yeong Yeh Lee Shuhua Xu Nur-Shafawati Rajab Norhazrini Hasan Syed Hassan Syed Abdul Aziz Noorizan Abdul Majid Bin Alwi Zilfalil | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 2 | Improvement in quality of life measures and stimulation of weight gain after treatment with megestrol acetate oral suspension in geriatric cachexia : results of a double - blind, placebo controlled study显示文摘 | Yeh SS Wu SY Lee TP | 2004 | J AM Geriatr Soc2004，48，5： | 1 |
| 3 | Related Articles, Links A clinical study of endodontic flare- ups 显示文摘 | Yeh SJ Lin YT Lu SY | 1994 | Changgeng Yi Xue Za Zhi1994，17，2： | 1 |
| 4 | Resonance frequency assessment of dental implant stability with various bone qualities:a numerical approach显示文摘 | Huang HM Lee SY Yeh CY | 2002 | Clin Oral Implants Res2002，13，1： | 1 |
| 5 | Related Articles, links A clinical study of endodontic flare - ups 显示文摘 | Yeh S J Lin YT Lu SY | 1994 | Changgeng yi Xue Za Zhi1994，17，2： | 1 |
| 6 | Improvement in quality-of-life meas- ures and stimulation of weight gain after treatment with megestrol ace- tate oral suspension in geriatric eachexia: results of a double-lind pla- cebo controlled study显示文摘 | Yeh SS Wu SY Lee TP | 2000 | J Am Geriatr Soc2000，48，5： | 1 |
| 7 | A close-form solution for a confined inflow into a tunnel during progressive drilling in a multi-layer groundwater flow system显示文摘 | Yang SY Yeh HD | | 0，，07： | 1 |
| 8 | Hyalinizing clear cell carcinoma of hard palate显示文摘 | Tsai CC Yeh SY | 2004 | J Laryngol Otol2004，118，： | 1 |
| 9 | OBDD-based network reliability calculation显示文摘 | FU MIN YEH SY YEN KUO | 1997 | Electronics Letters1997，33，9： | 1 |
| 10 | Determining terminal-pair network reliability based on edge expansion diagrams using OBDD 显示文摘 | SY YEN KUO SHYUE KUNG LU FU MIN YEH | 1999 | IEEE Trans- actions on Reliability1999，48，3： | 1 |
| 11 | Tamoxifen inhibits hepatoma cells growth through an estrogen receptor inde- pendent mechanism显示文摘 | Jiang SY Shyu RY Yeh MY | 1995 | J Hepatol1995，23，6： | 1 |
| 12 | Resonance frequency assessment of dental implant stability with various bone qualities: a numerical approach 显示文摘 | Huang HM Lee SY Yeh CY | 2002 | Clin Oral Implants Res2002，13，1： | 1 |
| 13 | OBDD-based evaluation of k-terminal network reliability 显示文摘 | FU MIN YEH SHYUE KUNG LU SY YEN KUO | 2002 | IEEE Transactions on Reliability2002，51，4： | 1 |
| 14 | Single-molecule detection and probe strategies for rapid and ultrasensitive genomic detection显示文摘 | Yeh HC Chao SY Ho YP | 2005 | Curr Pharm Biotechnol2005，6，6： | 1 |
| 15 | Dual-energy computed tomo- graphy in pulmonary embolism 显示文摘 | Lu GM Wu SY Yeh BM | 2010 | Brit J Radiol2010，83，992： | 1 |
| 16 | Glucosyltransferases of viridans streptococci are modulins of interleukin-6 induction in infective endocarditis 显示文摘 | Shun CT Lu SY Yeh CY | 2005 | Infect Immun2005，73，6： | 1 |
| 17 | Genetic alterations of p16INK4a and p14ARF genes in human bladder cancer显示文摘 | Chang LL Yeh WT Yang SY | 2003 | J Urol2003，170，21： | 1 |
| 18 | Chen WT- Promoter CpG methylation of tumorsuppressor genes in colorectal cancer and its relationship to clinicalfeatures显示文摘 | Lin SY’ Yeh KT | 2004 | Oncol Rep2004，11，2： | 1 |
| 19 | Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001-11 显示文摘 | Raghu G Chen SY Yeh WS | 2014 | Lancet Respir Med2014，2，7： | 1 |
| 20 | Frontal function, disabil- ity and caregiver burden in elderly patients with major de- pressive disorder显示文摘 | Chen HM Hou SY Yeh YC | 2010 | Kaohsiung Journal of Medical Sciences2010，26，： | 1 |
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