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| 1 | Multi-sensor Hybrid Fusion Algorithm Based on Adaptive Square-root Cubature Kalman Filter显示文摘处于正常操作条件,一个常规方形根的求容积法 Kalman 过滤器(SRCKF ) 给足够地好的评价结果。然而,如果大小不是可靠的, SRCKF 可以给不精密的结果并且到时间分叉。这研究与过滤器获得修正介绍一个适应 SRCKF 算法因为测量的盒子失灵。由建议一个切换的标准,一个最佳的过滤器根据测量质量从适应、常规的 SRCKF 被选择。一个分系统软差错察觉算法与过滤器剩余被造。利用一个清楚的分系统差错系数,有缺点的分系统由于系统重建被孤立。以便改进多传感器系统的性能,一个混合熔化算法基于适应 SRCKF 被介绍。状态和错误协变性矩阵被 priori 熔化估计也预言,并且被分系统的预言并且估计的信息更新。建议算法被用于容器动态放系统模拟。他们与正常 SRCKF 和本地评价相比是加权的熔化算法。模拟结果证明介绍适应 SRCKF 改进分系统过滤的坚韧性,并且混合熔化算法有更好的表演。模拟验证建议算法的有效性。 | Xiaogong Lin Shusheng Xu Yehai Xie | 2013 | Journal of Marine Science and Application2013，12，1： | 6 |
| 2 | Tumor necrosis factor a accelerates Hep-2 cells proliferation by suppressing TRPP2 expression显示文摘TRPP2, a Ca^(2+)-permeable non-selective cation channel, has been shown to negatively regulate cell cycle, but the mechanism underlying this regulation is unknown. Tumor necrosis factor a(TNF-α) is a proinflammatory cytokine extensively involved in immune system regulation, cell proliferation and cell survival. However, the effects and mechanisms for the role of TNF-αin laryngeal cancer remain unclear. Here, we demonstrated using western blot analyses and intracellular Ca^(2+) concentration measurements that TNF-α treatment suppressed both TRPP2 expression and ATP-induced Ca^(2+) release in a laryngeal cancer cell line(Hep-2). Knockdown of TRPP2 by a specific siRNA significantly decreased ATP-induced Ca^(2+) release and abolished the effect of TNF-α on the ATP-induced Ca^(2+) release. TNF-α treatment also enhanced Hep-2 cell proliferation and growth, as determined using cell counting and flow cytometry cell cycle assays. Moreover, TNF-α treatment down-regulated phosphorylated protein kinase R-like endoplasmic reticulum kinase(p-PERK) and phosphorylated eukaryotic translation initiation factor(p-eIF2α)expression levels, without affecting PERK and eIF2 a expression levels in Hep-2 cells. We concluded that suppressing TRPP2 expression and TRPP2-mediated Ca^(2+) signaling may be one mechanism underlying TNF-α-enhanced Hep-2 cell proliferation.These results offer new insights into the mechanisms of TNF-α-mediated laryngeal cancer cell proliferation, and provide evidences showing a potential role of TNF-α in the development of laryngeal cancer. | Jing Wu Jizheng Guo Yunyun Yang Feifei Jiang Shuo Chen Kaile Wu Bing Shen Yehai Liu Juan Du | 2017 | Science China(Life Sciences)2017，60，11： | 2 |
| 3 | Photocatalytic oxidative desulfurization of dibenzothiophene catalyzed by amorphous TiOz in ionic liquid 显示文摘 | Zhu Wenshuai Xu Yehai Li Huaming | 2014 | Korean J Chem Eng2014，31，2： | 1 |
| 4 | A novel uniplanar compact photonic bandgappower plane with ultra-broadband suppression ofground bounce noise显示文摘 | WANG Xiaohua WANG Bingzhong BI Yehai etal | 2006 | IEEE Microwave and Wire-less Components Letters*2006，16，5： | 1 |
| 5 | Rheological, thermal, and mechanical characterizations of polystyrene/single-walled carbon nanotube composites显示文摘 | Yehai Yan Jinfang Zhang Jian Cui Junmei Cheng Jiwen Liu | 2012 | Colloid and Polymer Science2012，，： | 1 |
| 6 | Fabrication of large SU-8 mold with high aspect ratio microchannels by UV exposure dose reduction显示文摘 | Zhang Jun Yan Yehai | 2004 | Sensors and Actuators B2004，101，： | 1 |
| 7 | Ace- tyl-capped paraformaldehyde as crosslinking agent for BMI- modified novolac resin for resin transfer molding 显示文摘 | YAN Yehai ZHI Linjie WANG Hongsheng | 2002 | J Appl Polym Sci2002，86，5： | 1 |
| 8 | Thermoset- ting resin system based on novolak and bismaleimide for res- in-transfer molding 显示文摘 | YAN Yehai SHI Xianming LIU Jinge | 2002 | J Appl Polym Sci2002，83，8： | 1 |
| 9 | Grafting of aldehyde struc- tures to single - walled carbon nanntubes for application in phenolic resin -based composites显示文摘 | Yehai Yah Shuai Zhao Jian Cui et at | 2009 | Journal of polymer science part A: Poly- mer Chemistry2009，47，22： | 1 |
| 10 | Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma显示文摘Objective: Ferroptosis is a novel cell death process which displays a promising role in cancer treatment.However, clinically available drugs targeting ferroptosis are rarely used, and yet there are no studies reporting on inducing ferroptosis via Chinese herbal extracts. Here we explored the tumor inhibition effects of Ganoderma lucidum(G. lucidum) on oral squamous cell carcinoma(OSCC). Specifically, we aimed to clarify the biological mechanism of components in the dietary, aqueous-soluble sporoderm-removed G. lucidum spore powder(A-GSP).Methods: Preliminary transcriptome analysis revealed the significant enrichment of the ferroptosis pathway.Cellular Fe2+, glutathione(GSH), malondialdehyde(MDA), reactive oxygen species(ROS) and lipid peroxide levels were measured to identify ferroptosis occurrence. Western blotting was used to measure ferroptosis-related proteins. Changes in mitochondria morphology and function were observed with transmission electron microscopy(TEM) and ATP detection assays. Ferroptosis inhibitor ferrostatin-1 was then used to verify the anti-tumor effects of A-GSP. Finally, nude mice xenograft models of oral cancer confirmed that A-GSP inhibited tumor growth.Results: A-GSP promoted ferroptosis in oral cancer cells by inducing Fe2+influx, GSH depletion, as well as lipid peroxide and ROS accumulation. Ferroptosis-related proteins exhibited corresponding changes, particularly Acylco A synthetase long chain family member 4(ACSL4) increase and glutathione peroxidase 4(GPX4) decrease. A-GSP considerably lowered mitochondrial volume and ridge number, while significantly decreasing ATP production. Ferrostatin-1 reversed all of these A-GSP-induced changes. In vivo, A-GSP exerted a ferroptosismediated tumor-suppressing effect without observable adverse reactions.Conclusions: Our findings demonstrate the therapeutic potential of A-GSP for treating patients with OSCC by targeting ferroptosis. | Xiangping Wu Qingnan Wu Yan Wang Yehai Liu Zhenhao Li Qingchuan Liu Zhengming Huang Mingyan Li Bin Zhang Qimin Zhan | 2023 | Chinese Journal of Cancer Research2023，35，2： | 0 |
| 11 | Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of most common and deadliest malignancies.Celastrol(Cel),a natural product derived from the Tripterygium wilfordii plant,has been extensively researched for its potential effectiveness in fighting cancer.However,its clinical application has been hindered by the unclear mechanism of action.Here,we used chemical proteomics to identify the direct targets of Cel and enhanced its targetability and antitumor capacity by developing a Cel-based liposomes in HCC.We demonstrated that Cel selectively targets the voltage-dependent anion channel 2(VDAC2).Cel directly binds to the cysteine residues of VDAC2,and induces cytochrome C release via dysregulating VDAC2-mediated mitochondrial permeability transition pore(mPTP)function.We further found that Cel induces ROS-mediated ferroptosis and apoptosis in HCC cells.Moreover,coencapsulation of Cel into alkyl glucoside-modified liposomes(AGCL)improved its antitumor efficacy and minimized its side effects.AGCL has been shown to effectively suppress the proliferation of tumor cells.In a xenograft nude mice experiment,AGCL significantly inhibited tumor growth and promoted apoptosis.Our findings reveal that Cel directly targets VDAC2 to induce mitochondria-dependent cell death,while the Cel liposomes enhance its targetability and reduces side effects.Overall,Cel shows promise as a therapeutic agent for HCC. | Piao Luo Qian Zhang Shuo Shen Yehai An Lixia Yuan Yin-Kwan Wong Sizhe Huang Shaohui Huang Jingnan Huang Guangqing Cheng Jiahang Tian Yu Chena Xiaoyong Zhang Weiguang Li Songqi He Jigang Wang Qingfeng Du | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，6： | 0 |
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