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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Spinal and extracranial metastatic dissemination of malignant glioma显示文摘 | Ng WH Yeo n Kaye AH | 2005 | J Clin Neurosci2005，12，4： | 1 |
| 3 | Prevalence of invasive fungal disease in hematological patients at a tertiary university hospital in Singapore显示文摘 | Lee SY Yeo CL Lee WH Kwa AL.Koh LP.Hsu LY | | 0，，： | 1 |
| 4 | Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs显示文摘 | Kim WH Yeo M Kim MS | 2000 | Int J Colorectal Dis2000，15，2： | 1 |
| 5 | High carriage rate of TTV virus in the cervices of pregnant women显示文摘 | Tam WH Yeo W | 2001 | Clin Infect Dis2001，32，9： | 1 |
| 6 | Role of Caspase 3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs显示文摘 | Kim WH Yeo M Kim MS | 2000 | Int J ColorectDis2000，15，： | 1 |
| 7 | Nitric oxide and subarachnoid hemorrhage:elevated level in cerebrospinal fluid and their implications显示文摘 | Ng WH Moochhala S Yeo TT | 2001 | Nurosurgery2001，49，3： | 1 |
| 8 | A randomised controlled trial of prophylactic levonorgcst r el intrauterine system in tarnoxifen?treated women显示文摘 | Chan SS Tam WH Yeo W | 2007 | BJOG2007，114，12： | 1 |
| 9 | Docetaxel-loaded thermo- sensitive liquid suppository: optimization of theological properties 显示文摘 | Yeo WH Ramasamy T Kim DW | 2013 | Arch Pharm Res2013，36，12： | 1 |
| 10 | Docetaxel-loaded thermosensitive and bioadhesive nanomicelles as a recta/drug delivery system for en- hanced chemotherapeutic effect 显示文摘 | Seo YG Kim DW Yeo WH | 2013 | Pharm Res2013，30，7： | 1 |
| 11 | A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women显示文摘 | Chan SS Tam WH Yeo W | 2007 | BJOG2007，114，12： | 1 |
| 12 | Epidemiology of anemia in heart failure显示文摘 | Tang WH Yeo PS | 2010 | Heart Fail Clin2010，6，： | 1 |
| 13 | ER stress is implicated in mi- tochondrial dysfunction-induced apoptosis of pancreatic beta cells显示文摘 | Lee JW Kim WH Yeo J Jung MH | 2010 | Mol Ce//s2010，30，6： | 1 |
| 14 | Nitric oxide and subarachnoidhemorrhage:elevated level in cerebrospinal fluidand their implications显示文摘 | Ng WH Moochhala S Yeo TT | 2001 | Neurosurgery2001，49，3： | 1 |
| 15 | Spinal and extracranial metastatie dissemination of malignant 显示文摘 | Ng WH Yeo TT Kaye AH | 2005 | J Clin Neurosci2005，12，4： | 1 |
| 16 | Prevalence of invasive fungal disease in hematological patients at a tertiary university hos- pital in Singapore显示文摘 | Lee SY Yeo CL Lee WH | 2011 | BMC Res Notes2011，4，： | 1 |
| 17 | Role of caspase-3 in apoptosisof colon cancer cells induced by nonsteroidal anti-inflammatorydrugs显示文摘 | KIM WH YEO M KIM MS f | 2000 | Int J Colorectal Dw2000，15，2： | 1 |
| 18 | Non -traumatic spontaneous acute epidural haematoma - report of two cases and review of the literature 显示文摘 | Ng WH Yeo TT Seow WT | 2004 | J Clin Neurosci2004，11，7： | 1 |
| 19 | Multifunctional epidermal elec- tronics printed directly onto the skin显示文摘 | Yeo WH Kim YS Lee J | 2013 | Adv Mater2013，25，20： | 1 |
| 20 | A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen- treated women 显示文摘 | Chan SS Tam WH Yeo W | 2007 | BJOG2007，114，12： | 1 |
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