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| 1 | Chronic intermittent hypoxia induces cardiac inflammation and dysfunction in a rat obstructive sleep apnea model显示文摘Chronic intermittent hypoxia is considered to play an important role in cardiovascular pathogenesis during the development of obstructive sleep apnea(OSA).We used a well-described OSA rat model induced with simultaneous intermittent hypoxia.Male Sprague Dawley rats were individually placed into plexiglass chambers with air pressure and components were electronically controlled.The rats were exposed to intermittent hypoxia 8 hours daily for 5weeks.The changes of cardiac structure and function were examined by ultrasound.The cardiac pathology,apoptosis,and fibrosis were analyzed by H&E staining,TUNNEL assay,and picosirius staining,respectively.The expression of inflammation and fibrosis marker genes was analyzed by quantitative real-time PCR and Western blot.Chronic intermittent hypoxia/low pressure resulted in significant increase of left ventricular internal diameters(LVIDs),endsystolic volume(ESV),end-diastolic volume(EDV),and blood lactate level and marked reduction in ejection fraction and fractional shortening.Chronic intermittent hypoxia increased TUNNEL-positive myocytes,disrupted normal arrangement of cardiac fibers,and increased Sirius stained collagen fibers.The expression levels of hypoxia induced factor(HIF)-l α,NF-κB,IL-6,and matrix metallopeptidase 2(MMP-2) were significantly increased in the heart of rats exposed to chronic intermittent hypoxia.In conclusion,the left ventricular function was adversely affected by chronic intermittent hypoxia,which is associated with increased expression of HIF-lα and NF-κB signaling molecules and development of cardiac inflammation,apoptosis and fibrosis. | Qin Wei Yeping Bian Fuchao Yu Qiang Zhang Guanghao Zhang Yang Li Songsong Song Xiaomei Ren Jiayi Tong | 2016 | The Journal of Biomedical Research2016，30，6： | 15 |
| 2 | A secure and rapid response architecture for virtual machine migration from an untrusted hypervisor to a trusted one显示文摘 | Tao WU Qiusong YANG Yeping HE | 2017 | Frontiers of Computer Science2017，11，5： | 1 |
| 3 | Bifurcations and chaotic thresholds for the spring-pendulum oscillator with irrational and fractional nonlinear restoring forces显示文摘 | Ruilan Tian Qiliang Wu Yeping Xiong Xinwei Yang Wenjie Feng | 2014 | The European Physical Journal Plus2014，，5： | 1 |
| 4 | Organ-specific alterations in circadian genes by vertical sleeve gastrectomy in an obese diabetic mouse model显示文摘Current therapies for obesity and related complications have been shown to have limited benefits,including unsatisfactory weight loss and poor metabolic improvement.With recent developments in bariatric surgery,promising advancements have been made in clinical and scientific research,particularly in the management of obesity and diabetes.Vertical sleeve gastrectomy(VSG)has become increasingly popular due to its safety,simplicity, | Qiwei Shen Yeping Yang Wenjuan Liu Meng Wang Yikai Shao Bo Xu Xiaolong Zhao Jinxing Zhu Rong Hua Wanzhu Jin Zhiyu Hu Jae Bum Kim Qinghua Wang Yiming Li Mengwei Zang Qiyuan Yao Zhaoyun Zhang | 2017 | Science Bulletin2017，62，7： | 0 |
| 5 | Preventive Effect of Xiangsha Yangwei Pills on the Novel Coronavirus Pneumonia from'Genuine Qi Exists,Illness Never'显示文摘The preventive effect of traditional Chinese medicine on the novel coronavirus(COVID-19)pneumonia is embodied in the'prevention before disease onset'of'treatment of disease'theory of thought,and it is considered that the key to the success or failure of prevention is whether the healthy qi is abundant or not.This article discusses and understands the'genuine qi'from the The Medical Classic of the Yellow Emperor,and describes its meaning comprehensively and systematically,combining with the expansion and supplement of many doctors in later generations.The'genuine qi'includes healthy qi,pulse qi,congenital qi,personal qi,Jing qi primordial qi and food energy,all of which are closely related to spleen-stomach.The function of spleen-stomach is normal,water and grain are transported properly,and the rise and fall of qi is appropriate,then the human body's qi is abundant,the anti-evil force is strong,and people are not easy to cause disease;even if the disease,the prognosis is better.This the novel coronavirus pneumonia comprehensive analysis,belongs to the traditional Chinese medicine science'damp-toxin epidemic',therefore the prevention should pay more attention to strengthen spleen and stomach,eliminate dampness,and Xiangsha Yangwei Pills is the appropriate choice. | Rong LI Yongqiang KANG Yuxin JIA Maosheng RAN Xiujuan ZHAO Yeping YANG Caiyun MI | 2021 | Medicinal Plant2021，12，2： | 0 |
| 6 | Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits显示文摘Temporal lobe epilepsy(TLE),one common type of medically refractory epilepsy,is accompanied with altered adult-born dentate granule cells(abDGCs).However,the causal role of abDGCs in recurrent seizures of TLE is not fully understood.Here,taking advantage of optogenetic and chemogenetic tools to selectively manipulate abDGCs in a reversible manner. | Liying Chen Yingwei Xu Heming Cheng Zhongxia Li Nanxi Lai Menghan Li Yeping Ruan Yang Zheng Fan Fei Cenglin Xu Jiao Ma Shuang Wang Yan Gu Feng Han Zhong Chen Yi Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 0 |
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