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| 1 | Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth显示文摘 | Yi Yang Chia-Wei Li Li-Chuan Chan Yongkun Wei Jung-Mao Hsu Weiya Xia Jong-Ho Cha Junwei Hou Jennifer L. Hsu Linlin Sun Mien-Chie Hung | 2018 | Cell Research2018，28，8： | 35 |
| 2 | Palmitoylation stabilizes PD-L1 to promote breast tumor growth显示文摘Dear Editor,PD-L1 is a well-known transmembrane protein, which is highly expressed on many types of cancer cells. By binding to its receptor PD-1 on T cells, PD-L1 significantly inhibits T cells activation and activity, and thus plays a pivotal role in driving the escape of tumor cells from immune surveillance.^1. | Yi Yang Jung-Mao Hsu Linlin Sun Li-Chuan Chan Chia-Wei Li Jennifer L. Hsu Yongkun Wei Weiya Xia Junwei Hou Yufan Qiu Mien-Chie Hung | 2019 | Cell Research2019，29，1： | 14 |
| 3 | Methylprednisolone Inhibits the Expression of Glial Fibrillary Acidic Protein and Chondroitin Sulfate Proteoglycans in Reactivated Astrocytes显示文摘创伤后的神经胶质增生导致硫酸软骨素蛋白聚糖(CSPG)的显著表达,从而抑制轴突生长和再生。甲基强地松龙(MP),一种合成的糖皮质激素,在急性脊髓损伤(SCI)的治疗中有神经保护作用和抗炎效应。但是,MP对于CSPG在活性胶质细胞中的表达的作用尚不清楚。本文用a-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯(AM-PA)诱导星形胶质细胞再活化,用环噻嗪模拟SCI的兴奋性中毒刺激。AMPA治疗后,星形胶质细胞再活化的标志物-胶质纤维酸性蛋白(GFAP)、CSPG神经聚糖和磷酸盐的表达都显著上调。AMPA治疗星形胶质细胞的条件培养液强烈抑制大鼠背根神经节中神经元的轴突生长,但这种作用能被MP的预处理所逆转。此外,MP下调成年SCI大鼠中GFAP和CSPG的表达,对抗RU486的糖皮质激素受体(GR)和GR si RNA能逆转MP对GFAP和神经聚糖表达的抑制作用。这些结果提示,MP能在兴奋性中毒损伤后通过GR介导的星形胶质细胞再活化下调和GSPG表达抑制来改善神经修复,促进轴突生长。 | WEI-LIN LIU YI-HSUAN LEE SHIH-YING TSAI CHUNG YI HSU YU-YO SUN LIANG-YO YANG SHING-HAN TSAI AND WEI-CHUNG VIVIAN YANG | 2008 | 神经损伤与功能重建2008，3，5： | 9 |
| 4 | Damage detection of a thin plate using modal curvature via macrostrain measurement显示文摘Plate structures are employed as important structural components in many engineering applications. Hence, assessing the structural conditions of in-service plate structures is critical to monitoring global structural health. Modal curvature-based damage detection techniques have recently garnered considerable attention from the research community, and have become a promising vibration-based structural health monitoring solution. However, computing errors arise when calculating modal curvatures from lateral mode shapes, which result from unavoidable measurement errors in the mode shapes as identified from lateral vibration signals; this makes curvature-based algorithms that use a lateral measurement only theoretically feasible, but practically infeasible. Therefore, in this study, long-gauge fiber Bragg grating strain sensors are employed to obtain a modal curvature without a numerical differentiation procedure in order to circumvent the computing errors. Several damage indices based on modal curvatures that were developed to locate beam damage are employed. Both numerical and experimental studies are performed to validate the proposed approach. However, although previous studies have reported relative success with the application of these damage indices on a simple beam, only one damage index demonstrated the capability to locate damage when the stiffness of the local region changed near the sensor. | Ting Yu Hsu Yi Cheng Shih Quang-Vinh Pham | 2019 | Earthquake Engineering and Engineering Vibration2019，18，2： | 7 |
| 5 | Engineering the surface of LiCoO2 electrodes using atomic layer deposition for stable high-voltage lithium ion batteries显示文摘 | Jin Xie Jie Zhao Yayuan Liu Haotian Wang Chong Liu Tong Wu Po-Chun Hsu Dingchang Lin Yang Jin Yi Cui | 2017 | Nano Research2017，10，11： | 6 |
| 6 | Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity显示文摘 | F. Ann Ran Patrick D. Hsu Chie-Yu Lin Jonathan S. Gootenberg Silvana Konermann Alexandro E. Trevino David A. Scott Azusa Inoue Shogo Matoba Yi Zhang Feng Zhang | 2013 | Cell2013，，2： | 4 |
| 7 | Low effect‐site concentration of propofol target‐controlled infusion reduces the risk of hypotension during endoscopy in a T aiwanese population显示文摘 | Wen‐Hung Hsu Sophie SW Wang Hsiang‐Yao Shih Meng‐Chieh Wu Yi‐Yu Chen Fu‐Chen Kuo Hui‐Ying Yang Shun‐Li Chiu Koung‐Shing Chu Kuang‐I Cheng Deng‐Chyang Wu I‐Cheng Lu | 2013 | Journal of Digestive Diseases2013，，3： | 3 |
| 8 | Levofloxacin-Amoxicillin/Clavulanate-Rabeprazole versus a Standard Seven-Day Triple Therapy for Eradication of Helicobacter pylori Infection显示文摘 | Ming-Cheh Chen Wei-Yi Lei Jen-Shung Lin Chih-Hsun Yi Deng-Chyang Wu Chi-Tan Hu Pin-I Hsu | 2014 | BioMed Research International2014，，： | 3 |
| 9 | Adult metaplastic hutch diverticulum with robotic-assisted diverticulectomy and reconstruction:A case report显示文摘BACKGROUND Hutch diverticulum arises from the compromised muscular development at the ureteral orifice.It is a congenital disease and extremely rare in adult,only accounting for about 3%occurrence worldwide.It can be either symptomatic or asymptomatic,and relies on image tools for diagnosis and preoperative planning.Indications for surgery are dependent on the complications from the diverticulum.Metaplasia is about 10%among those with hutch diverticulum,and it still has chances turning into malignancy,especially urothelial cell carcinoma.CASE SUMMARY A 27-year-old man was presented with frequently recurrent urinary tract infection for one year,and had suffered from intermittent right flank pain for 3 mo.No past medical histories were recorded before.No obvious abnormalities on laboratory data and urine examination were found.Under ultrasound,right hydronephrosis was seen and an anatomical abnormality was observed on intravenous pyelography.Further computed tomography urogram showed one diverticulum seated at superolateral side of right ureteral orifice.Cystoscopy was done and biopsy results showed focal metaplasia.After discussing with him,roboticassisted diverticulectomy with reconstruction was performed.Right hydronephrosis was greatly improved after surgery.He has completed his 1.5-year follow-ups,and no malignancies were seen from urine cytology and image of intravenous pyelography.CONCLUSION Robotic-assisted diverticulectomy and reconstruction to hutch diverticulum is a safe and efficient operation,providing several advantages over open and laparoscopic ones. | Che H Yang Yi S Lin Yen C Ou Wei C Weng Li H Huang Chin H Lu Chao Y Hsu Min C Tung | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 10 | Determinants of delayed diagnosis and treatment of tuberculosis in Cambodia:a mixed-methods study显示文摘Background:Cambodia is among the 30 countries in the world with the highest burden of tuberculosis(TB),and it is estimated that 40%of people with TB remain undiagnosed.In this study,we aimed to investigate the determinants of delayed diagnosis and treatment of TB in Cambodia.Methods:This mixed-method explanatory sequential study was conducted between February and September 2019 in 12 operational districts in Cambodia.It comprised of a retrospective cohort study of 721 people with TB,followed by a series of in-depth interviews.We assessed factors associated with time to TB diagnosis and treatment initiation using Cox proportional hazards model.Subsequently,we conducted in-depth interviews with 31 people with TB purposively selected based on the time taken to reach TB diagnosis,sex,and residence.Transcripts were coded,and thematic analyses were performed.Results:The median time from the onset of symptoms to TB diagnosis was 49 days(Interquartile range[IQR]:21–112).We found that longer time to diagnosis was significantly associated with living in rural area(Adjusted hazards ratio[aHR]=1.25;95%confidence interval[CI]:1.06–1.48);TB symptoms-cough(aHR:1.52;95%CI:1.18–1.94),hemoptysis(aHR 1.32;95%CI:1.07–1.63),and night sweats(aHR:1.24;95%CI:1.05–1.46);seeking private health care/self-medication(aHR:1.23;95%CI:1.04–1.45);and higher self-stigma(aHR:1.02;95%CI:1.01–1.03).Participants who received education level above the primary level were inversely associated with longer time to diagnosis(aHR:0.78;95%CI:0.62–0.97).The median time from TB diagnosis to the initiation of treatment was two days(IQR:1–3).The use of smear microscopy for TB diagnosis(aHR:1.50;95%CI:1.16–1.95)was associated with longer time to treatment initiation.Seeking private health care and self-medication before TB diagnosis,lack of perceived risk,threat,susceptibility,and stigma derived qualitatively further explained the quantitative findings.Conclusions:TB diagnostic delay was substantial.Increasing public awareness about TB and consciousness regarding stigma,engaging the private healthcare providers,and tailoring approaches targeting the rural areas could further improve early detection of TB and narrowing the gap of missing cases in Cambodia. | Alvin Kuo Jing Teo Chetra Ork Sothearith Eng Ngovlyly Sok Sovannary Tuot Li Yang Hsu Siyan Yi | 2020 | Infectious Diseases of Poverty2020，9，3： | 2 |
| 11 | MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis显示文摘 | Tsai Wei-Chih Hsu Sheng-Da Hsu Chu-Sui Lai Tsung-Ching Chen Shu-Jen Shen Roger Huang Yi Chen Hua-Chien Lee Chien-Hsin Tsai Ting-Fen Hsu Ming-Ta Wu Jaw-Ching Huang Hsien-Da Shiao Ming-Shi Hsiao Michael Tsou Ann-Ping | 2012 | EN2012，，8： | 2 |
| 12 | Dimension and frequency of bar formation in a braided river显示文摘This paper presents flume and field observations of a bank-confined braided river.Morphological features,including plan form configuration,channel width,and main channel migration,were examined by a series of experiments.Repeated measurements of channel morphology,provided a basis to estimate the relationship between noncumulative frequency of bars and bar area.Additional results from the Dajia River,located in Central Western Taiwan,were presented to provide a reference data set for comparing the laboratory and field data.The results indicate that the relationship between bar length and width can be predicted by a simple best-fit power function relating to self-similarity characteristics.The Hurst index by Walsh and Hicks(2002) provides acceptable predictions of the bar length and width observed in the experiments and confirmed by the field investigations.Eexperimental and field results both show that large river width yields a uniform distribution of bar areas with the similar discharge,leading to a large value of exponent(ft) in the model.The river width is confirmed to be a critical parameter in the main channel shift.A small increase in channel width likely increased rapidly the shift cycle. | Hsuan-pei AN Su-chin CHEN Hsun-chuan CHAN Yi HSU | 2013 | International Journal of Sediment Research2013，28，3： | 2 |
| 13 | Nitrite Anion Provides Potent Cytoprotective and Antiapoptotic Effects as Adjunctive Therapy to Reperfusion for Acute Myocardial Infarction显示文摘 | Felix M. Gonzalez Sruti Shiva Pamela S. Vincent Lorna A. Ringwood Li-Yueh Hsu Yuen Yi Hon Anthony H. Aletras Richard O. Cannon Mark T. Gladwin Andrew E. Arai | 2008 | Circulation2008，，23： | 2 |
| 14 | Morphology and property investigation of primary particulate matter particles from different sources显示文摘 | Rufan Zhang Chong Liu Guangmin Zhou Jie Sun Nian Liu Po-Chun Hsu Haotian Wang Yongcai Qiu Jie Zhao Tong Wu Wenting Zhao Yi Cui | 2018 | Nano Research2018，11，6： | 2 |
| 15 | Blood neutrophil‐to‐lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer显示文摘 | Chien‐Liang Liu Jie‐Jen Lee Tsang‐Pai Liu Yuan‐Ching Chang Yi‐Chiung Hsu Shih‐Ping Cheng | 2012 | J. Surg. Oncol2012，，5： | 2 |
| 16 | The Efficacy of Second‐Line Anti‐ Helicobacter pylori Therapy Using an Extended 14‐Day Levofloxacin/Amoxicillin/Proton‐Pump Inhibitor Treatment – A Pilot Study显示文摘 | Seng‐Kee Chuah Wei‐Chen Tai Pin‐I Hsu Deng‐Chyang Wu Keng‐Liang Wu Chung‐Mou Kuo Yi‐Chun Chiu Ming‐Luen Hu Yeh‐Pin Chou Yuan‐Hung Kuo Chih‐Ming Liang King‐Wah Chiu Tsung‐Hui Hu | 2012 | Helicobacter2012，，5： | 2 |
| 17 | Residual Daily Urine Volume Association with Inflammation and Nutrition Status in Maintenance Hemodialysis Patients显示文摘 | Po Yi YangJa Liang Lin Dan Tzu Lin Tan Ching Wei Hsu | 2009 | Renal Failure2009，31，6： | 1 |
| 18 | Performance evaluation of efficient and reliable routing protocols for fixed-power sensor networks显示文摘 | PETER K K L HSU W J YI P | | 0，，05： | 1 |
| 19 | Eight-year follow-up of locally advanced lymphoepithelioma-like carcinoma at upper urinary tract: A case report显示文摘BACKGROUND Urinary tract lymphoepithelioma-like carcinoma is rarely seen.Although it is termed after lymphoepithelioma at the nasopharynx,it behaves more like high grade urothelial carcinoma by immunohistochemical features.Most published literatures focused on its rarity but few discussed results of long-term follow-ups.As no available guidelines are applicable,we postulated that principles should be similar to that of urothelial carcinoma at urinary tract.As of now,this work features the longest follow-up of this cancer at the upper urinary tract.CASE SUMMARY A 63-year-old female had a chief complaint of intermittent left flank pain for 2 mo,along with accompanying symptoms including vomiting and body weight loss,about 7 kg over 2 mo.Laboratory data showed normocytic anemia,mildly poor renal function,and hyperparathyroidism.Urine analysis showed mild hematuria.Computed tomography showed a 4.2-cm-width irregular mass over left renal pelvic and enlarged lymph node at the left renal hilum.Whole-body bone scan was negative of active bone lesions.Biopsy from ureteroscopy showed urothelial carcinoma.Specimen from laparoscopic nephroureterectomy with bladder cuff resection showed lymphoepithelioma-like carcinoma with muscular invasion(pT3).She took adjuvant chemotherapies of 2 cycles and full courses of radiation therapy.No recurrence was observed with designed investigative programs.CONCLUSION Locally advanced urinary tract lymphoepithelioma-like carcinoma could benefit from nephroureterectomy and bladder cuff excision in terms of recurrence-free survival. | Che H Yang Wei C Weng Yi S Lin Li H Huang Chin H Lu Chao Y Hsu Yen C Ou Min C Tung | 2020 | World Journal of Clinical Cases2020，8，19： | 1 |
| 20 | Cadmium toxicity is reduced by nitric in rice leaves显示文摘 | Yi Ting Hsu Ching Huei Kao | 2004 | Plant Growth Regulation2004，42，： | 1 |
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