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| 1 | Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats显示文摘AIM To explore the kinetic changes in plasma D (-)lactate and lipopolysaccharide ( LPS ) levels, and investigate whether D (-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/reperfusion, burn, and acute necrotizing pancreatitis (ANP).METHODS Three models were developed in rats:gut ischemia/reperfusion obtained by one hour of superior severe burn injury created by 30% of total body surface induced by continuous inverse infusion of sodium taurocholate and trypsin into main pancreatic duct.Plasma levels of D( - )-lactate in systemic circulation and LPS in portal circulation were measured by enzymaticspectrophotometric method and limulus amebocyte lysate (LAL) test kit, respectively. Tissue samples of intestine were taken for histological analysis.RESULTS One hour gut ischemia followed by reperfusion injuries resulted in a significant elevation in plasma D( - )lactate and LPS levels, and there was a significant correlation between the plasma D( - )-lactate and LPS (r =0.719, P<0.05). The plasma concentrations of D(-)lactate and LPS increased significantly at 6 h postburn,and there was also a remarkable correlation between them (r = 0.877, P < 0.01). D ( - )-lactate and LPS levels elevated significantly at 2 h after ANP, with a similar significant correlation between the two levels (r-0.798,P < 0.01 ). The desquamation of intestine villi and infiltration of inflammatory cells in the lamina propria were observed in all groups.CONCLUSION The changes of plasma D( - )-lactate levels in systemic blood paralleled with LPS levels in the portal vein blood. The measurement of plasma D (-)-lactate level may be a useful marker to assess the intestinal injury and to monitor an increase of intestinal permeability and endotoxemia following severe injuries in early stage. | Xiao-Qing Sun Xiao-Bing Fu Rong-Zhan Yi Lü Qun Deng Xiao-Guo Jian Zhi-Yong Sheng Bum Institute, 304~(th)Hospital,Beijing 100037,China Department of General Surgery,Chinese PLA 304 Hospital,Beijing 100037,China | 2001 | World Journal of Gastroenterology2001，7，4： | 56 |
| 2 | Stem cell and pe- ripheral nerve injury and repair 显示文摘 | Dong MM Yi TH | 2010 | Facial Plast Surg2010，26，： | 1 |
| 3 | Tissue-engineered nipple recons-truction显示文摘 | Cao YI Lach E Kim TH | 1998 | Plast Reconstr Surg1998，102，7： | 1 |
| 4 | Post-exposure treatment with ginsenoside compound kameliorates auditory functional injury associated with noise-induced hearing loss in mice显示文摘 | Hong BN Kim SY Yi TH | 2011 | Neurosci Lett2011，487，2： | 1 |
| 5 | Two variants of MutS homolog hMSH5:Prevalence in humans and effects on protein interaction显示文摘 | Yi W Wu X Lee TH | | 0，，02： | 1 |
| 6 | Benign pulmonary metastasizing leiomvomatosis: case report and a review of the literature显示文摘 | Kwon YI Kim TH Sohn JW | 2006 | Korean J Intern Med2006，21，3： | 1 |
| 7 | Methylated DNA immuno-precipitation and microarray-based analysis:detection ofDNA methylation in breast cancer cell lines显示文摘 | Weng YI Huang TH Yan PS | 2009 | MethodsMol Biol2009，590，1： | 1 |
| 8 | Benign pulmonary metastasizing leiomvomatosis: case report and a review of the literature显示文摘 | Kwon YI Kim TH Sohn JW | 2006 | Korean J Intern Med2006，21，3： | 1 |
| 9 | Benign Pulmonary Metastasizing Leiomyomatosis:Case Report and a Review of the Literature显示文摘 | Kwon YI Kim TH Sohn JW | 2006 | Korean J Intern Med2006，21，3： | 1 |
| 10 | Alteration of epithelial-mesenchymal transition markers in human normal ovaries and neoplastic ovarian cancers显示文摘 | Yi BR Kim TH Kim YS | 2015 | Int J Oncol2015，46，1： | 1 |
| 11 | Exposure to Bisphenol A Affects Lipid Metabolism in Drosophila melanogaster显示文摘 | Michael J. Williams Yi Wang Anica Klockars P. Monica Lind Robert Fredriksson Helgi B. Schi?th | 2014 | Basic Clin Pharmacol Toxicol2014，，5： | 1 |
| 12 | Three-dimensional conformal radiotherapy of unresectable hepatocellular carcinoma patients for whom transcatheter arterial chemoembolization was ineffective or unsuitable 显示文摘 | Kim TH Kim DY Park JW Kim YI | 2006 | Am J Clin Oncol2006，29，6： | 1 |
| 13 | Association between oxielative stress and changes of trace elements in patients with breast Cancer显示文摘 | Shen JY Lin TH | 1999 | Clin Biochan1999，32，2： | 1 |
| 14 | Alteration of epitheliaLmes- enchymal transition markers in human normal ovaries and neo- plastic ovarian cancers显示文摘 | YI BR KIM TH KIM YS | 2015 | Int J Oncol2015，46，1： | 1 |
| 15 | Stem cell and peripheral nerve injury and repair显示文摘 | Dong MM Yi TH | 2010 | Facial Plast Surg2010，26，5： | 1 |
| 16 | Relationship between Epstein- Barr virus-encoded RNA expression, apoptosis and lymphocytic infiltration in gastric carcinoma with lymphoid-rich stroma 显示文摘 | Cho MY Kim TH Yi SY | 2004 | Med Princ Pract2004，13，： | 1 |
| 17 | Stem Cel and Peripheral Nerve Injury and Repair显示文摘 | Dong MM Yi TH | | 0，，05： | 1 |
| 18 | Characterzation of dental follicle cells in developing mouse molar显示文摘 | Cheing ML Yi JC | 1999 | Arch Oral Biol1999，44，9： | 1 |
| 19 | Coffee improves auditory neuropathy in diabetic mice显示文摘 | Hong BN Yi TH Park R | 2008 | Neurosci Lett2008，441，3： | 1 |
| 20 | Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats显示文摘 | Ming KT Yun LL Yi TH | 2010 | Toxicology and Applied Pharmacology2010，242，2： | 1 |
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