3篇
您的检索式：作者名="Yigan Zhang"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | NAT 10 promotes gastric cancer metastasis via N4-acetylated COL5A1显示文摘Dear Editor,Gastric cancer(GC)is among the most prevalent gastrointestinal malignancies.The occurrence of local deep infiltration or distant metastasis in GC is commonly associated with weak treatment and poor prognosis.1 Although,N4-Acetylcytidine(ac4C)represents one of the extensive chemical modifications in mRNAs that plays a pivotal role in modulating mRNA stability and the mRNA translation process(Fig.1b). | Yigan Zhang Yuanxue Jinq Yinxue Wanq Jianming Tang Xiaoran Zhu Wei-Lin Jin Yiqing Wang Wenzhen Yuan Xiangkai Li Xun Li | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 1 |
| 2 | ADAR1:a mast regulator of aging and immunity显示文摘Recently,Nature and Nature Cell Biology published five papers on the function and molecular mechanism of ADAR1(adenosine deaminases acting on RNA)in aging,cancer,and autoimmune diseases.1,2,3,4,5 Among them,four papers published in Nature revealed that ADAR1 regulates autoimmune disease and cancer immunotherapy through canonical adenosine-to-inosine(A-to-I)RNA editing. | Yigan Zhang Jinyue Zhang Yuanchao Xue | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 3 | Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets显示文摘Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease progression.As an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease development.Extensive research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue concentration.This has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer progression.Zinc transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc intake.Additionally,the storage of this essential element is predominantly mediated by metallothioneins(MTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on cancer.We also compile a summary of clinical trials involving zinc ions.Given the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration. | Bonan Chen Peiyao Yu Wai Nok Chan Fuda Xie Yigan Zhang Li Liang Kam Tong Leung Kwok Wai Lo Jun Yu Gary MKTse Wei Kang Ka Fai To | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员