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| 1 | Using big data to track marine oil transportation along the 21st-century Maritime Silk Road显示文摘China's designation of the '21 st-century Maritime Silk Road'(MSR) region is of extraordinary significance to its maritime rights, transportation security, and socio-economic development. We developed a technical framework allowing the use of 'big data' derived from the Automatic Identification System(AIS, an automatic ship-tracking network) for two purposes: the accurate mapping of oil tanker trajectories and the creation of heat maps showing the relative use of oil tanker routes and marine shipping chokepoints. We then applied these methods to 1.5 billion AIS records collected within the MSR in 2014 to statistically identify and analyze busy routes, areas, and chokepoints in this strategic region. Our results demonstrate that the proposed framework can provide an effective analysis of oil movements based on large-scale AIS datasets, helping researchers and policy makers better understand the footprint and strategic implications of maritime oil transportation in the MSR region. | CHENG Liang YAN ZhaoJin XIAO YiJia CHEN YanMing ZHANG FangLi LI ManChun | 2019 | Science China(Technological Sciences)2019，62，4： | 3 |
| 2 | Antimicrobial Chlorinated Carbazole Alkaloids from the Sponge-Associated Actinomycete Streptomyces diacarni LHW51701显示文摘Four new chlorinated carbazole alkaloids,chlocarbazomycins(CCBs)A-D,were isolated from sponge associated bacterium Streptomyces diacarni LHW51701.Their structures were elucidated via spectroscopic techniques(including HRESIMS,ID&2D NMR),and X-ray crystallographic analysis.Structurally,the 4-chloro coupled with 3-methoxyl substituents in the tricycle nucleus of CCBs A-D and the A/-methoxyl group of CCB-D are rare in naturally occurred tricyclic carbazole alkaloids.Moreover,CCBs A-D do not bear the typical Cl poro-alkyl and C2 meto-methyl side chains of bacterial tricycle carbazoles,suggesting a novel mechanism of aromatic ring formation in biosynthesis.The biological evaluation showed that CCB-C possessed inhibitory activities against pathogenic microorganisms including methicillin-resistant Staphylococcus aureus(MRSA),Mycobacterium smegmatis,Bacillus mycoides,and Candida albicans. | Yijia Cheng Nannan Chen Jing Li Jun-Cheng Su Jingya Yang Cui-Xian Zhang Hou-Wen Lin Yongjun Zhou | 2021 | Chinese Journal of Chemistry2021，39，5： | 3 |
| 3 | Investigation of carbonyl amidation and O-methylation during biosynthesis of the pharmacophore pyridyl of antitumor piericidins显示文摘Piericidins are a large family of bacterialα-pyridone antibiotics with antitumor activities such as their anti-renal carcinoma activity exhibited recently in nude mice.The backbones of piericidins are derived fromβ,δ-diketo carboxylic acids,which are offloaded from a modular polyketide synthase(PKS)and putatively undergo a carbonyl amidation beforeα-pyridone ring formation.The tailoring modifications to theα-pyridone structure mainly include the verified hydroxylation and O-methylation of the C-4′position and an unidentified C-5′O-methylation.Here,we describe a piericidin producer,terrestrial Streptomyces conglobatus,which contains a piericidin biosynthetic gene cluster in two different loci.Deletion of the amidotransferase gene pieD resulted in the accumulation of two fatty acids that should be degraded from the nascent carboxylic acid released by the PKS,supporting the carbonyl amidation function of PieD duringα-pyridone ring formation.Deletion of the O-methyltransferase gene pieB1 led to the production of three piericidin analogues lacking C-5′O-methylation,therefore confirming that PieB1 specifically catalyses the tailoring modification.Moreover,bioactivity analysis of the mutant-derived products provided clues regarding the structure-function relationship for antitumor activity.The work addresses two previously unidentified steps involved in pyridyl pharmacophore formation during piericidin biosynthesis,facilitating the rational bioengineering of the biosynthetic pathway towards valuable antitumor agents. | Wanlu Li Wenyu Zhang Yijia Cheng Yaoyao Shen Jianzhao Qi Hou-Wen Lin Yongjun Zhou | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 2 |
| 4 | A novel DMTL capacitive switch with electrostatic actuation MAM capaci- tors 显示文摘 | Deng Cheng Bao Jingfu Du Yijia | 2012 | Microsystem Technologies2012，18，5： | 1 |
| 5 | Ice-volume and insolation influences on hydroclimate changes in central eastern China during the antepenultimate glacial period显示文摘The rainfall changes in East Asian summer monsoon(EASM)regions on the orbital timescale remain controversial due to the lack of reliable rainfall records.Here,we present new multiproxy records(δ^(18)O,δ^(13)C,Sr/Ca and Mg/Ca)of a230Thdated stalagmite from Hulu Cave in central eastern China.Multiproxy records reconstruct a regional hydroclimate history from 340 to 261 kyr BP(thousand years before present),approximately covering the antepenultimate glacial period.Theδ^(18)O record is dominated by the precessional cycles,suggesting that EASM responds to changes in Northern Hemisphere summer insolation(NHSI)on the orbital timescale.Significant correlations amongst theδ^(13)C,Sr/Ca and Mg/Ca suggest that a common factor,i.e.,the local hydrological cycle,controlled their variability,and their leading principal component can be used as a proxy linked to regional rainfall.This composite record bears a good similarity to those from the Chinese Loess Plateau,showing a gradually decreasing rainfall during the antepenultimate glacial period,consistent with changes in global ice volume.Superimposed on the long-term trend,three relative wetter intervals were responding to the higher NHSI periods,suggesting that EASM rainfall variability was induced by integrated effects of global ice volume and NHSI.The increased ice sheets and lower NHSI resulted in an increased meridional temperature gradient and southward shift of the westerlies,which shortened the duration of Meiyu and midsummer rainfall.The differences between the rainfall record and the stalagmiteδ^(18)O record indicate that the latter represents the overall EASM intensity linked to monsoon circulation,but does not directly reflect the rainfall changes at the cave sites. | Quan WANG Shayue YUAN Yijia LIANG Kan ZHAO Qingfeng SHAO Zhenqiu ZHANG Junji ZHU Xinggong KONG Yongjin WANG Jianghu LAN Hai CHENG Chengwei XIA Yi LI | 2023 | Science China Earth Sciences2023，66，1： | 0 |
| 6 | Pilomatrixoma causing irreversible peripheral eyebrow shedding:A case report显示文摘Pilomatrixomas are benign tumors derived from hair stromal cells;however,their exact etiology is unknown.A 31-year-old woman presented with a subcutaneous mass located precisely above the left eyebrow,with shedding of eyebrow hair around the mass,and the shedding area gradually expanded.Surgical removal of the mass failed to prevent eyebrow loss,and the entire left eyebrow shed 6 months postoperatively.Pathology and histology of the biopsy specimen revealed a pilomatrixoma comprising basaloid cells and ghost cells,with basaloid cells expressing high bcl-2 levels.Instead of apoptosis,the emergence and growth of pilomatrixoma-induced microinflammation around the hair follicles of the eyebrow may lead to eyebrow loss. | Zeren Shen Fei Cheng Yanqin Dai Yijia Yu Lulu Ye Jinghong Xu | 2023 | Chinese Journal Of Plastic and Reconstructive Surgery2023，5，1： | 0 |
| 7 | A bi-functional strategy involving surface coating and subsurface gradient co-doping for enhanced cycle stability of LiCoO_(2) at 4.6 V显示文摘Layered LiCoO_(2)(LCO)acts as a dominant cathode material for lithium-ion batteries(LIBs)in 3C products because of its high compacted density and volumetric energy density.Although improving the high cutoff voltage is an effective strategy to increase its capacity,such behavior would trigger rapid capacity decay due to the surface or/and structure degradation.Herein,we propose a bi-functional surface strategy involving constructing a robust spinel-like phase coating layer with great integrity and compatibility to LiCoO_(2) and modulating crystal lattice by anion and cation gradient co-doping at the subsurface.As a result,the modified LiCoO_(2)(AFM-LCO)shows a capacity retention of 80.9%after 500 cycles between 3.0and 4.6 V.The Al,F,Mg enriched spinel-like phase coating layer serves as a robust physical barrier to effectively inhibit the undesired side reactions between the electrolyte and the cathode.Meanwhile,the Al,F,Mg gradient co-doping significantly enhances the surficial structure stability,suppresses Co dissolution and oxygen release,providing a stable path for Li-ions mobility all through the long-term cycles.Thus,the surface bi-functional strategy is an effective method to synergistically improve the electrochemical performances of LCO at a high cut-off voltage of 4.6 V. | Yun He Xiaoliang Ding Tao Cheng Hongyu Cheng Meng Liu Zhijie Feng Yijia Huang Menghan Ge Yingchun Lyu Bingkun Guo | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 8 | Flow-induced voltage generation in graphene network显示文摘我们基于一个 graphene 网络(GN ) 报导一个电压发电机。响应在 GN 脱衣上的离子的答案的微滴的运动,几百毫伏特的电压在周围的条件下面被观察。在电压产生过程, GN 的唯一的结构在改进电子转移的率起一个重要作用。给他们的优秀机械性质, GN 可以为在象被暴露下雨的雨衣,伞,窗口,和另外的表面那样的各种各样的地方收获震动的精力发现应用。 | Junchao Lao Yijia He Xiao Li FuzhangWu Tingting Yang Miao Zhu Yangyang Zhang Pengzhan Sun Zhen Zhen Baochang Cheng Hongwei Zhu | 2015 | Nano Research2015，8，8： | 0 |
| 9 | A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer显示文摘Modulating Tankyrases(TNKS),interactions with USP25 to promote TNKS degradation,rather than inhibiting their enzymatic activities,is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway.Here,we identified UAT-B,a novel neoantimycin analog isolated from Streptomyces conglobatus,as a small-molecule inhibitor of TNKS-USP25 protein-protein interaction(PPI)to overcome multi-drug resistance in colorectal cancer(CRC).The disruption of TNKS-USP25 complex formation by UAT-B led to a significant decrease in TNKS levels,triggering cell apoptosis through modulation of the Wnt/β-catenin pathway.Importantly,UAT-B successfully inhibited the CRC cells growth that harbored high TNKS levels,as demonstrated in various in vitro and in vivo studies utilizing cell line-based and patient-derived xenografts,as well as APC^(min/+)spontaneous CRC models.Collectively,these findings suggest that targeting the TNKS-USP25 PPI using a small-molecule inhibitor represents a compelling therapeutic strategy for CRC treatment,and UAT-B emerges as a promising candidate for further preclinical and clinical investigations. | Hongrui Zhu Yamin Gao Liyun Liu Mengyu Tao Xiao Lin Yijia Cheng Yaoyao Shen Haitao Xue Li Guan Huimin Zhao Li Liu Shuping Wang Fan Yang Yongjun Zhou Hongze Liao Fan Sun Houwen Lin | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 10 | Enhanced wide-angle third-harmonic generation in flat-band-engineered quasi-BIC metagratings显示文摘Nonlinear metasurfaces and photonic crystals provide a significant way to generate and manipulate nonlinear signals owing to the resonance-and symmetry-based light-matter interactions supported by the artificial structures.However,the nonlinear conversion efficiency is generally limited by the angular dispersion of optical resonances especially in nonparaxial photonics.Here,we propose a metagrating realizing a quasi-bound-state in the continuum in a flat band to dramatically improve the third harmonic generation(THG)efficiency.A superior operating angular range is achieved based on the interlayer and intralayer couplings,which are introduced by breaking the mirror symmetry of the metagrating.We demonstrate the relation of angular dispersion between the nonlinear and linear responses at different incident angles.We also elucidate the mechanism of these offaxis flat-band-based nonlinear conversions through different mode decomposition.Our scheme provides a robust and analytical way for nonparaxial nonlinear generation and paves the way for further applications such as wide-angle nonlinear information transmission and enhanced nonlinear generation under tight focusing. | Yijia Zang Ruoheng Chai Wenwei Liu Zhancheng Li Hua Cheng Jianguo Tian Shuqi Chen | 2024 | Science China(Physics,Mechanics & Astronomy)2024，67，4： | 0 |
| 11 | Synergistic effect of fluorinated solvent and Mg^(2+)enabling 4.6 V LiCoO_(2)performances显示文摘Increasing the charging cut-off potential of lithium cobalt oxide(LiCoO_(2),LCO)can effectively improve the energy density of the lithium-ion batteries,which are the mainstream energy storage devices used in 3C electronic products.However,the continuous decomposition of the electrolyte and dissolution of Co from the electrode will occur at high-potential operation,which deteriorate the performances of LCO.Here,a cathode-electrolyte interface(CEI)layer containing Mg F_(2)is constructed to enhance the electrochemical stability of LCO at 4.6 V(vs.Li^(+)/Li).The Mg^(2+)added to the cathode gradually releases into the electrolyte during cycling,which forms a stable Mg F_(2)-rich protective layer.In addition,1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropylether(TTE)is added to the electrolyte acting as a F source to increase the content of Mg F_(2)in the CEI layer.The Mg F_(2)-rich CEI layer effectively suppresses the decomposition of electrolyte components and the dissolution of Co of LCO,which makes the Li||LiCoO_(2)(Li||LCO)cell cycled stably at 3~4.6 V(vs.Li^(+)/Li)in 200 cycles with a retention of 83.9%. | Yijia Huang Yidan Zhu Hongyu Cheng Meng Liu Yingying Song Xiaoliang Ding Kaiyun Xu Yinping Qin Yang Liu Bingkun Guo | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
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