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| 1 | NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens显示文摘像点头的受体(NLR ) 是对微生物引起的感染在天生的免疫起关键作用的细胞内部的蛋白质的一个家庭。NLRC5, NLR 家庭的最大的成员,最近吸引了许多注意。然而,在 vitro,研究在主人防卫并且在调整有免疫力的发信号的小径关于 NLRC5 的角色报导了不一致的结果。在里面 NLRC5 的 vivo 功能仍然保持未知。这里,我们报导 NLRC5 是对在 vivo 的细胞内部的病原体的主人防卫的一个批评管理者。NLRC5 明确地为涉及 MHC 一级抗原表示的基因的表示被要求。NLRC5 缺乏的老鼠显示了在 MHC 一级基因和伴随物失败的表示的一个深刻缺点激活 L。monocytogenes 特定的 CD8 + T 房间回答,包括的激活,增长和 cytotoxicity,和变异的老鼠更产生病原体感染。调停 NLRP3 的 inflammasome 激活部分也在 NLRC5 缺乏的老鼠被损害。然而, NLRC5 为 NF-κ 的导致病原体的表示是非必需的; B 依赖的支持 inflammatory 基因以及类型我干扰素基因。因此, NLRC5 极其调整 MHC 一级抗原表示控制细胞内部的病原体感染。 | Yikun Yao Yalong Wang Fuxiang Chen Yin Huang Shu Zhu Qibin Leng Hongyan Wang Yufang Shi Youcun Qian | 2012 | Cell Research2012，22，5： | 13 |
| 2 | Expression regulation and function of NLRC5显示文摘The NOD like receptors(NLRs),a class of intracellular receptors that respond to pathogen attack or cellular stress,have gained increasing attention.NLRC5,the largest member of the NLR protein family,has recently been identified as a critical regulator of immune responses.While NLRC5 is constitutively and widely expressed,it can be dramatically induced by interferons during pathogen infections.Both in vitro and in vivo studies have demonstrated that NLRC5 is a specifi c and master regulator of major mistocompatibility complex(MHC)class I genes as well as related genes involved in MHC class I antigen presentation.The expression of MHC class I genes is regulated by NLRC5 in coordination with the RFX components through an enhanceosome-dependent manner.And the involvement of NLRC5 in MHC class I mediated CD8^(+)T cell activation,proliferation and cytotoxicity is proved to be critical for host defense against intracellular bacterial infections.Nevertheless,the role of NLRC5 in innate immunity remains to be further explored.Here,we review the research advances on the structure,expression regulation and function of NLRC5. | Yikun Yao Youcun Qian | 2013 | Protein & Cell2013，4，3： | 5 |
| 3 | PIF3 Is Involved in the Primary Root Growth Inhibition of Arabidopsis Induced by Nitric Oxide in the Light显示文摘PHYTOCHROME 交往 FACTOR3 (PIF3 ) 是在表明小径的 phytochrome 的一个重要部件并且调停植物 responsesto 各种各样的环境条件。我们发现 PIF3 涉及氮的氧化物导致的 Arabidopsis thaliana 幼苗的根生长的抑制(没有) 在光。PIF3 的 Overexpression 部分减轻了禁止的效果不在根生长上,而 pif3-1 异种显示了提高的敏感到不以根生长。在 phytochrome 发信号期间,光敏电阻器 PHYBmediates PIF3 的降级。我们发现 phyB-9 异种而且以应答有类似的显型到 PIF3ox 的到号码,没有处理支持了 PHYB 的累积,并且因此进一步减少了 PIF3 content.Our 结果证明 PIF3 的活动被 DELLA 蛋白质 RGL3 调整[象 3 一样的 RGA ( ga1-3 的抑压者)]。因此,我们推测那 PIF3 PHYB 和 RGL3 下游地躺,并且在禁止的效果起一个重要作用不在在 light.Key 词的 Arabidopsis 幼苗的根生长上: | Sulan Bai Tao Yao Miaomiao Li Xiaomin Guo Yaochuan Zhang Shengwei Zhu Yikun He | 2014 | Molecular Plant2014，7，4： | 3 |
| 4 | Multi-Objective Redundancy Optimization of Continuous-Point Robot Milling Path in Shipbuilding显示文摘The 6-DOF manipulator provides a new option for traditional shipbuilding for its advantages of vast working space,low power consumption,and excellent flexibility.However,the rotation of the end effector along the tool axis is functionally redundant when using a robotic arm for five-axis machining.In the process of ship construction,the performance of the parts’protective coating needs to bemachined tomeet the Performance Standard of Protective Coatings(PSPC).The arbitrary redundancy configuration in path planning will result in drastic fluctuations in the robot joint angle,greatly reducing machining quality and efficiency.There have been some studies on singleobjective optimization of redundant variables,However,the quality and efficiency of milling are not affected by a single factor,it is usually influenced by several factors,such as the manipulator stiffness,the joint motion smoothness,and the energy consumption.To solve this problem,this paper proposed a new path optimization method for the industrial robot when it is used for five-axis machining.The path smoothness performance index and the energy consumption index are established based on the joint acceleration and the joint velocity,respectively.The path planning issue is formulated as a constrained multi-objective optimization problem by taking into account the constraints of joint limits and singularity avoidance.Then,the path is split into multiple segments for optimization to avoid the slow convergence rate caused by the high dimension.An algorithm combining the non-dominated sorting genetic algorithm(NSGA-II)and the differential evolution(DE)algorithm is employed to solve the above optimization problem.The simulations validate the effectiveness of the algorithm,showing the improvement of smoothness and the reduction of energy consumption. | Jianjun Yao Chen Qian Yikun Zhang Geyang Yu | 2023 | Computer Modeling in Engineering & Sciences2023，，2： | 0 |
| 5 | Targeting the ECM component HA:a new route for mCRC treatment显示文摘Colorectal cancer(CRC)is a complex and heterogeneous disease that is the second-leading cause of cancer-related deaths worldwide.Mesenchymal colorectal cancer(m CRC)accounts for about one-third of all CRC.Despite significant advances in understanding the molecular mechanisms underlying m CRC,effective treatments for patients with advanced disease remain limited,particularly for the aggressive mesenchymal subtype of CRC(Rawla et al.,2019). | Wanjing Shang Simone Gottlieb Yikun Yao | 2023 | Science China(Life Sciences)2023，66，8： | 0 |
| 6 | Death receptor 5 rises to the occasion显示文摘Death receptors(DRs),mediate death and inflammation in many cell types,especially in the immune system.In a study published in Cell Research,Du et al.present new structures of lipid membrane-anchored DR5 ectodomains(ECDs)leading to a new model of self-associated DR5 ECDs lying horizontal to the membrane prior to ligand engagement,termed pre-ligand self-association.The mechanisms of death receptor(DR)signaling have been extensively studied in past decades,yielding a wealth of information on how DRs transmit proinflammatory and programmed cell death(PCD)signals.1,2 DR5 belongs to the DR subfamily of tumor necrosis factor receptor superfamily(TNFRSF),which includes FAS/CD95,TNFR1,DR3,DR4,and DR6.Each of these is a type-I transmembrane protein composed of an extracellular portion with 3 or 4 cysteine-rich domains(CRDs),a transmembrane domain and an eponymous intracellular death domain(DD). | Lixin Zheng Yikun Yao Michael J.Lenardo | 2023 | Cell Research2023，33，3： | 0 |
| 7 | Fast design of catalyst layer with optimal electrical-thermal-water performance for proton exchange membrane fuel cells显示文摘The catalyst layer(CL)is the core component in determining the electrical-thermal-water performance and cost of proton exchange membrane fuel cell(PEMFC).Systemic analysis and rapid prediction tools are required to improve the design efficiency of CL.In this study,a 3D multi-phase model integrated with the multi-level agglomerate model for CL is developed to describe the heat and mass transfer processes inside PEMFC.Moreover,a research framework combining the response surface method(RSM)and artificial neural network(ANN)model is proposed to conduct a quantitative analysis,and further a rapid and accurate prediction.With the help of this research framework,the effects of CL composition on the electrical-thermal-water performance of PEMFC are investigated.The results show that the mass of platinum,the mass of carbon,and the volume fraction of dry ionomer has a significant impact on the electrical-thermal-water performance.At the selected points,the sensitivity of the decision variables is ranked:volume fraction of dry ionomer>mass of platinum>mass of carbon>agglomerate radius.In particular,the sensitivity of the volume fraction of dry ionomer is over 50%at these points.Besides,the comparison results show that the ANN model could implement a more rapid and accurate prediction than the RSM model based on the same sample set.This in-depth study is beneficial to provide feasible guidance for high-performance CL design. | Jing Yao Yuchen Yang Xiongpo Hou Yikun Yang Fusheng Yang Zhen Wu Zaoxiao Zhang | 2023 | Journal of Energy Chemistry2023，，6： | 0 |
| 8 | Real-Time Visual Tracking with Compact Shape and Color Feature显示文摘The colour feature is often used in the object tracking.The tracking methods extract the colour features of the object and the background,and distinguish them by a classifier.However,these existing methods simply use the colour information of the target pixels and do not consider the shape feature of the target,so that the description capability of the feature is weak.Moreover,incorporating shape information often leads to large feature dimension,which is not conducive to real-time object tracking.Recently,the emergence of visual tracking methods based on deep learning has also greatly increased the demand for computing resources of the algorithm.In this paper,we propose a real-time visual tracking method with compact shape and colour feature,which forms low dimensional compact shape and colour feature by fusing the shape and colour characteristics of the candidate object region,and reduces the dimensionality of the combined feature through the Hash function.The structural classification function is trained and updated online with dynamic data flow for adapting to the new frames.Further,the classification and prediction of the object are carried out with structured classification function.The experimental results demonstrate that the proposed tracker performs superiorly against several state-of-the-art algorithms on the challenging benchmark dataset OTB-100 and OTB-13. | Zhenguo Gao Shixiong Xia Yikun Zhang Rui Yao Jiaqi Zhao Qiang Niu Haifeng Jiang | 2018 | Computers, Materials & Continua2018，，6： | 0 |
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