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| 1 | Epidemiological features of four human plague cases in the Inner Mongolia Autonomous Region, China in 2019显示文摘This study aims to investigate cases of human plague in the Inner Mongolia Autonomous Region (IMAR), China, and to inform the development of plague prevention and control strategies. On 12th of November 2019, two herdsmen from Sunitezuo Banner, Xilingol League were diagnosed with pneumonic plague in Beijing, China. On November 16th, one resident of Xianghuang Banner, Xilingol League was diagnosed with bubonic plague in Huade County Hospital, Ulanqab, China. On 27th of November, one resident of Siziwang Banner was diagnosed with bubonic plague. In total, 78 close contacts were monitored over a period, but none of them developed symptoms. Plague outbreaks in animals had been reported in Sunitezuo Banner, Xianghuang Banner, and Siziwang Banner in 2019. Two of the four cases were related (husband and wife), but not the other two. All the cases may be associated with contact with rodents (hare) or infected fleas. The cases highlight the importance of early identification of plague cases in humans in order to stop further infection. This demonstrates the value of monitoring and ongoing vigilance on endemic diseases, the importance of updating medical training and raising public awareness about infectious diseases that even have not been observed over decades. | Feng Yilan Fan Mengguang Gao Yulong Li Jianyun Zhang Dayu Wang Shuyi Wang Wenrui | 2020 | Biosafety and Health2020，2，1： | 2 |
| 2 | Origin of Excellent Charge Storage Properties of Defective Tin Disulphide in Magnesium/Lithium-Ion Hybrid Batteries显示文摘Lithium-ion batteries(LIBs)are excellent electrochemical energy sources,albeit with existing challenges,including high costs and safety concerns.Magnesium-ion batteries(MIBs)are one of the potential alternatives.However,the performance of MIBs is poor due to their sluggish solid-state Mg^(2+) diffusion kinetics and severe electrode polarizability.Rechargeable magnesium-ion/lithium-ion(Mg^(2+)/Li^(+))hybrid batteries(MLHBs)with Mg^(2+) and Li+as the charge carriers create a synergy between LIBs and MIBs with significantly improved charge transport kinetics and reliable safety features.However,MLHBs are yet to reach a reasonable electrochemical performance as expected.This work reports a composite electrode material with highly defective two-dimensional(2D)tin sulphide nanosheets(SnS_(x))encapsulated in three-dimensional(3D)holey graphene foams(HGF)(SnS_(x)/HGF),which exhibits a specific capacity as high as 600 mAh g^(−1) at 50 mA g^(−1) and a compelling specific energy density of~330 Wh kg^(−1).The excellent electrochemical performance surpasses previously reported hybrid battery systems based on intercalation-type cathode materials under comparable conditions.The role played by the defects in the SnS_(x)/HGF composite is studied to understand the origin of the observed excellent electrochemical performance.It is found that it is closely related to the defect structure in SnS_(x),which offers percolation pathways for efficient ion transport and increased internal surface area assessable to the charge carriers.The defective sites also absorb structural stress caused by Mg^(2+) and Li+insertion.This work is an important step towards realizing high-capacity cathode materials with fast charge transport kinetics for hybrid batteries. | Xin Fan Mike Tebyetekerwa Yilan Wu Rohit Ranganathan Gaddam Xiu Song Zhao | 2022 | Nano-Micro Letters2022，14，11： | 0 |
| 3 | Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals显示文摘Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA,adenoviral vector and inactivated vaccines fail to induce.Here,we describe a candidate live attenuated vaccine strain of SARS-CoV-2 in which the NSP16 gene,which encodes 2′-O-methyltransferase,is catalytically disrupted by a point mutation.This virus,designated d16,was severely attenuated in hamsters and transgenic mice,causing only asymptomatic and nonpathogenic infection.A single dose of d16 administered intranasally resulted in sterilizing immunity in both the upper and lower respiratory tracts of hamsters,thus preventing viral spread in a contact-based transmission model.It also robustly stimulated humoral and cell-mediated immune responses,thus conferring full protection against lethal challenge with SARS-CoV-2 in a transgenic mouse model.The neutralizing antibodies elicited by d16 effectively cross-reacted with several SARS-CoV-2 variants.Secretory immunoglobulin A was detected in the blood and nasal wash of vaccinated mice.Our work provides proof-of-principle evidence for harnessing NSP16-deficient SARS-CoV-2 for the development of live attenuated vaccines and paves the way for further preclinical studies of d16 as a prototypic vaccine strain,to which new features might be introduced to improve safety,transmissibility,immunogenicity and efficacy. | Zi-Wei Ye Chon Phin Ong Kaiming Tang Yilan Fan Cuiting Luo Runhong Zhou Peng Luo Yun Cheng Victor Sebastien Gray Pui Wang Hin Chu Jasper Fuk-Woo Chan Kelvin Kai-Wang To Honglin Chen Zhiwei Chen Kwok-Yung Yuen Guang Sheng Ling Shuofeng Yuan Dong-Yan Jin | 2022 | Cellular & Molecular Immunology2022，19，5： | 0 |
| 4 | Magnesium/Lithium Hybrid Batteries Based on SnS_(2)-MoS_(2) with Reversible Conversion Reactions显示文摘The magnesium/lithium hybrid batteries(MLHBs)featuring dendrite-less deposition with Mg anode and Li-storage cathode are a promising alternative to Li-ion batteries for large-scale energy storage.However,their limited energy density limits their practical implementation.To improve this,beyond the commonly proposed intercalation compounds,high-capacity conversion-type cathodes based on heterostructures of tin sulphide-molybdenum disulphide(SnS_(2)-MoS_(2))are proposed in this work.Individual SnS_(2) is already a promising high-capacity electrode material for multivalent batteries and undergoes conversion reactions during the ion storage process.The introduction of S-deficient MoS_(2) enhances the reversibility of SnS_(2) in the conversion reaction via strong polysulfide anchoring and catalytic effect.Our results show that the SnS_(2)-MoS_(2) electrode achieves a high charge capacity of~600 mAhg^(-1) at 50mAg^(-1) and an excellent rate capability of 240mAhg^(-1) at 1000mAhg^(-1) with a negligible capacity fading rate of 0.063%per cycle across 1000 cycles.The results highlight a new direction toward designing 2D heterostructures as high-capacity cathodes beyond intercalation-type cathodes for multivalent-ion batteries. | Xin Fan Mike Tebyetekerwa Yilan Wu Rohit Ranganathan Gaddam Xiu Song Zhao | 2022 | Energy Material Advances2022，，1： | 0 |
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