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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Dosefinding study for the use of long acting gonadotro phin-releasing hormone analogues prior to ovarian stimulation for IVF 显示文摘 | Yin SF Lok IH Cheung LP | 2007 | Hum Reprod2007，16，3： | 1 |
| 3 | A Pilot Study on Three-Dimensional Visualization of Perforator Flaps by Using Angiography in Cadavers 显示文摘 | Tang M Yin Z Morris SF | 2008 | Plast Reconstr Surg2008，122，2： | 1 |
| 4 | A pilot study on three-dimensional visualization of perforator flaps by using angiography in cadavers显示文摘 | Tang M Yin Z Morris SF | | 0，，02： | 1 |
| 5 | Olivocochlear innervationmaintains the normal modiolar-pillar and habenular-cuticulargradients in cochlear synaptic morphology 显示文摘 | Yin Y Liberman LD Maison SF | 2014 | J Assoc ResOtolaryngol2014，15，4： | 1 |
| 6 | Involvement of oxidative stress- activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells 显示文摘 | Wang SF Yen JC Yin PH | 2008 | Toxicology2008，246，2： | 1 |
| 7 | Involvement of oxidative stress?activatedJNK signaling in the methamphetamine-induced cell death of human SH-SY5 Y cells显示文摘 | Wang SF YenJe Yin PH | 2008 | Toxicology2008，246，23： | 1 |
| 8 | Involvement of oxidative stress-activated JNK signaling in the methamphetamine- induced cell death of human SH-SY5Y cells显示文摘 | Wang SF Yen JC Yin PH | 2008 | Toxicology2008，246，： | 1 |
| 9 | Metabolic and inflammatory response after laparoscopic and abdominal hesterctomy显示文摘 | Yuen PM Mak TW Yin SF | 1998 | Am J Obstet Gynecol1998，179，1： | 1 |
| 10 | Dosefinding study for the use of long acting gonadotrophin - releasing hormone analogues prior to ovarian stimulation for IVF显示文摘 | Yin SF Lok IH Cheung LP | 2001 | Hum Reprod2001，16，3： | 1 |
| 11 | A Pilot Study on Three-Dimensional Visualization of Perforator Flaps by Using Angiography in Cadavers 显示文摘 | Tang M Yin Z Morris SF | 2008 | Plast Reconstr Surg2008，122，2： | 1 |
| 12 | China’s oil pollution in coastal waters situation and control measures显示文摘 | CAI CX JIAO SF YIN YZ | 2012 | Chemical technol- ogy and development2012，41，8： | 1 |
| 13 | A pilot study on three-dimensional visualization of perforator flaps by using angiography in cadavers显示文摘 | Tang M Yin Z Morris SF | 2008 | Plast Reconstr Surg2008，122，2： | 1 |
| 14 | Surface integrity and removal mechanism in simulated dental finishing of a feldspathic porcelain显示文摘 | Yin L Song XF Qu SF | | J Biomed Mater Res Part B0，，： | 1 |
| 15 | Carbon nanotubes-supported Ru catalyst for the generation of COx-free hydrogen from ammonia显示文摘 | Yin SF Xu BQ Zhu WX | 2004 | Catalysis Today2004，9395，： | 1 |
| 16 | A Pilot Study on Three-Dimensional Visualization of Perforator Flaps by Using Angiography in Cadavers显示文摘 | Tang M Yin Z Morris SF | 2008 | Plast Reconstr Surg2008，122，2： | 1 |
| 17 | A pilot study on three-dimensional visualization of perforator flaps by using angiography in cadavers 显示文摘 | Tang M Yin Z Morris SF | 2008 | Plast Reconstr Surg2008，122，2： | 1 |
| 18 | A pilot study on three-dimensional vsualization of perforator flaps by using angiography in cadavers显示文摘 | Tang M Yin Z Morris SF | 2008 | Plast Reconstr Surg2008，122，2： | 1 |
| 19 | Peptidase allergen Der p 1 initiates apoptosis of epithelial cells independently of tight junction proteolysis显示文摘 | Baker SF Yin Y Runswick SK | 2003 | Mol Membr Biol2003，20，1： | 1 |
| 20 | Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells显示文摘 | Wang SF Yen JC Yin PH | 2008 | Toxicology2008，246，23： | 1 |
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