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| 1 | Inhibitory effect of agmatine on proliferation of tumor cells by modulation of polyamine metabolism显示文摘Aim: To assess the inhibitory effect of agmatine on tumor growth in vivo and tumor cell proliferation in vitro. Methods: The transplanted animal model,[^3H]thymidine incorporation assay, 3-[4,5-dimethythiazol-2-yl]-2,5-diphenyltetrazolium assay, and lactate dehydrogenase (LDH) release assay were performed.Results: Agmatine, at doses of 5-40mg/kg, suppressed the S180 sarcoma tumor growth dose-dependently in mice in vivo and the highest inhibitory ratio reached 31.3% in Kunming mice and 50.0% in Balb/c mice, respectively. Similar results were obtained in the transplanted B16 melanoma tumor model. Agmatine (1-1000μmol/L) was able to attenuate the proliferation of cultured MCF-7 human breast cancer cells in vitro in a concentration-dependent manner and the highest inhibitory ratio reached 50.3% in the [^3H]thymidine incorporation assay.Additionally, in the LDH release assay, spermine (20μmol/L) and spermidine (20μmol/L) increased the LDH release significantly, but agmatine (1-1000μmol/L) did not, indicating that the inhibitory effect of agmatine on the proliferation of MCF was not related to cellular toxicity. In the [^3H]thymidine incorporation assay,putrescine (12.5-100.0μmol/L) could reverse the inhibitory effect of agmatine on the proliferation of MCF concentration-dependently, suggesting that the inhibitory effect of agmatine on the proliferation of MCF might be associated with a decreased level of the intracellular polyamines pool. Conclusion: Agmatine had significant inhibitory effect on transplanted tumor growth in vivo and proliferation of tumor cells in vitro, and the mechanism might be a result of inducing decrease of intracellular polyamine contents. | Ji-fangWANG Rui-binSU NingWU BoXU Xin-qiangLU YinLIU JinLI | 2005 | Acta Pharmacologica Sinica2005，26，5： | 3 |
| 2 | Surgical management in metastatic gastrointestinal stromal tumor (GIST) patients after imatinib mesylate treatment显示文摘 | Chun‐NanYeh Tsung‐WenChen Jeng‐HweiTseng Yu‐YinLiu Shang‐YuWang Chun‐YiTsai Kun‐ChunChiang Tsann‐LongHwang Yi‐YinJan Miin‐FuChen | 2010 | J Surg Oncol2010，，6： | 1 |
| 3 | A Performance Analysis Tool for PVM Parallel Programs显示文摘In this paper,we introduce the design and implementation of ParaVT,which is a visual performance analysis and parallel debugging tool.In ParaVT,we propose an automated instrumentation mechanism.Based on this mechanism,ParaVT automatically analyzes the performance bottleneck of parallel applications and provides a visual user interface to monitor and analyze the performance of parallel programs.In addition,it also supports certain extensions. | ChenWang YinLiu ChangjunJiang ZhaoqingZhang | 2004 | 计算机工程与应用2004，40，29： | 1 |
| 4 | Anticonvulsive effect of agmatine in mice显示文摘AIM: The present study was designed to examine the effect of agmatine, the decarboxylated product of L-arginine by L- arginine decarboxylase, on convulsion in the mouse maximal electroshock (MES) test and mouse glutamate-induced convulsion test. METHODS: MES convulsion and glutamate convulsion were respectively induced by an electrical | Xin-QiangLu Rui-BinSu Xiao-LiWei YinLiu JinLi | 2004 | 中国药理通讯2004，21，2： | 0 |
| 5 | 氮添加抑制温带草甸草原凋落物的长期分解显示文摘植物凋落物分解是陆地生态系统碳平衡和养分周转的关键,对持续的人为氮输入增加十分敏感。氮素增加影响凋落物分解的研究大多依赖于短期实验,这可能掩盖氮素增加对凋落物分解的真实影响。因此,长期实验对于全面评价凋落物分解对氮素增加的响应是非常必要的。本研究基于氮添加实验(0-50 g N m^(-2) yr^(-1)),对羊草(Leymus chinensis)凋落物分解进行了长达4年的研究,探讨了影响凋落物分解的非生物和生物因子。研究结果表明,随着氮添加速率的增加,凋落物分解速率呈持续下降趋势,为氮添加抑制凋落物分解提供了可靠的证据。氮添加条件下土壤环境(酸化和养分化学计量学)、微生物活性(微生物生物量和酶活性)、凋落物质量(残余木质素和养分含量)和植物群落(地上生产力和物种丰富度)的变化共同导致了凋落物分解速率的降低。在分解过程中,凋落物质量的变化,包括木质素的积累和养分的残留,主要受土壤环境和微生物活性的影响。该研究有助于阐明不同氮添加速率对凋落物分解的长期影响,并有助于理解生态系统氮素增加与碳循环之间的关系及相关机理。 | Pei Zheng Ruonan Zhao Liangchao Jiang Guojiao Yang Yinliu Wang Ruzhen Wang Xingguo Han Qiushi Ning | 2023 | Journal of Plant Ecology2023，16，3： | 0 |
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