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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 2 | Proteome analysis of hepatocellular carcinoma by laser capture microdissection显示文摘 | Ai J Tan Y Ying W Hong Y Liu S Wu M Qian X Wang H | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 3 | Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells显示文摘AIM:To investigate effects of iron on oxidative stress, heme oxygenase-1(HMOX1)and hepatitis C viral(HCV) expression in human hepatoma cells stably expressing HCV proteins. METHODS:Effects of iron on oxidative stress,HMOX1, and HCV expression were assessed in CON1 cells. Measurements included mRNA by quantitative reverse transcription-polymerase chain reaction,and protein levels by Western blots. RESULTS:Iron,in the form of ferric nitrilotriacetate,increased oxidative stress and up-regulated HMOX1 gene expression.Iron did not affect mRNA or protein levels of Bach1,a repressor of HMOX1.Silencing the up-regulation of HMOX1 nuclear factor-erythroid 2-related factor 2(Nrf2)by Nrf2-siRNA decreased FeNTA-mediated up-regulation of HMOX1 mRNA levels.These iron effects were completely blocked by deferoxamine(DFO).Iron also significantly decreased levels of HCV core mRNA and protein by 80%-90%, nonstructural 5A mRNA by 90%and protein by about 50%in the Con1 full length HCV replicon cells, whereas DFO increased them. CONCLUSION:Excess iron up-regulates HMOX1 and down-regulates HCV gene expression in hepatoma cells.This probably mitigates liver injury caused by combined iron overload and HCV infection. | Wei-Hong Hou Lisa Rossi Ying Shan Jian-Yu Zheng Richard W Lambrecht Herbert L Bonkovsky | 2009 | World Journal of Gastroenterology2009，15，36： | 5 |
| 4 | Could saline irrigation clear all residual common bile duct stones after lithotripsy?A self-controlled prospective cohort study显示文摘BACKGROUND A previous study showed that irrigation with 100 mL saline reduced residual common bile duct(CBD)stones,which potentially cause recurrent stones after endoscopic retrograde cholangiopancreatography.AIM To determine whether saline irrigation can improve CBD clearance after lithotripsy.METHODS This prospective self-controlled study enrolled patients receiving mechanical lithotripsy for large(>1.2 cm)CBD stones.After occlusion cholangiography confirmed CBD stone clearance,peroral cholangioscopy(POC)was performed to determine clearance scores based on the number of residual stones.The amounts of residual stones spotted via POC were graded on a 5-point scale(score 1,worst;score 5,best).Scores were documented after only stone removal(control)and after irrigation with 50 mL and 100 mL saline,respectively.The stone composition was analyzed using infrared spectroscopy.RESULTS Between October 2018 and January 2020,47 patients had CBD clearance scores of 2.4±1.1 without saline irrigation,3.5±0.7 with 50 mL irrigation,and 4.6±0.6 with 100 mL irrigation(P<0.001).Multivariate analysis showed that CBD diameter>15 mm[odds ratio(OR)=0.08,95%confidence interval(CI):0.01-0.49;P=0.007]and periampullary diverticula(PAD)(OR=6.51,95%CI:1.08-39.21;P=0.041)were independent risk factors for residual stones.Bilirubin pigment stones constituted the main residual stones found in patients with PAD(P=0.004).CONCLUSION Irrigation with 100 mL of saline may not clear all residual CBD stones after lithotripsy,especially in patients with PAD and/or a dilated(>15 mm)CBD.Pigment residual stones are soft and commonly found in patients with PAD.Additional saline irrigation may be required to remove retained stones. | Yan-Yan Lin Yu-Dong Wang Ping Yue Xian-Zhuo Zhang Joseph W Leung Pan-Pan Jiao Man Yang Hai-Ping Wang Bing Bai Ying Liu Jin-Duo Zhang Hong-Bo Chen Wen-Bo Meng Xun Li | 2021 | World Journal of Gastroenterology2021，27，4： | 4 |
| 5 | Hierarchical attributed graph representation and recognition of handwritten Chinese characters显示文摘 | LU S W YING R SUEN C Y | 1991 | Pattern Recognition1991，24，18： | 1 |
| 6 | Effect of valsartan and captopril in rabbit carotid injury:possible involvement of bradykinin in the anti-proliferative action of the reninangiotensin blockade显示文摘 | Tong C F Ying W Y Hua R Y | 2001 | JRAAS2001，2，1： | 1 |
| 7 | Functional and surface-active membranes from poly(vinylidene fluoride)-graft-poly(acrylic acid) prepared via RAFT-mediated graft copolymerization显示文摘 | Ying L Yu W H Kang E T | 2004 | Langmuir2004，20，： | 1 |
| 8 | Possible use of ail and foxA polymorphisms fordetecting pathogenic Yersinia enterocolitica 显示文摘 | Ying H Xin W Cui Z | 2010 | BMC Microbiol2010，10，： | 1 |
| 9 | Optimal nonlinear feedback control strategy for randomly excited struc- tural systems显示文摘 | Zhu W Q Ying Z G Soong T T | 2001 | Nonlinear Dynamics2001，24，4： | 1 |
| 10 | Erectile function restoration after repair of resected cavernous nerves by adipose - derived stem cells combined with autologous vein graft in rats 显示文摘 | Ying C Hu W Cheng B | 2014 | Cell Mel Neurebio12014，34，3： | 1 |
| 11 | Barriers to Accessing Tb Diagnosisfor Rural-to-urban Migrants with Chronic Cough in Chongqing, China:a Mixed Methods Study显示文摘 | QIAN L YING L YANG W | 2008 | BMC Health Serv Res2008，8，6： | 1 |
| 12 | Studies on rechargeable Ni/MH batteries显示文摘 | YING T GAO X HU W | 2006 | Int J Hydrogen Energy2006，31，： | 1 |
| 13 | Cervical corpectomy with preserved posterior vertebral wall for cervical spondylotic myelopathy: a randomized control clinical study显示文摘 | Ying Z Xinwei W Jing Z | 2007 | Spine2007，32，14： | 1 |
| 14 | Fuzzy Control Theory: A Nonlinear Case显示文摘 | Ying H Siler W Buckley J J | 1990 | Automatica1990，26，3： | 1 |
| 15 | Proteomic characterization of early-stage differentiation of mouse embryonic stem cells into neural cells induced by all -trans retinoic acid in vitro显示文摘 | Guo X Ying W Wan J | 2001 | Electrophoresis2001，22，14： | 1 |
| 16 | Design and implementation of dependable CAN-based distributed systems显示文摘 | Ying X W | 2001 | PALBUS Task Technical Report2001，，1： | 1 |
| 17 | Nitro- gen-doped graphene and its application in electrochemical biosensing显示文摘 | WANG YING SHAOYUYAN MATSON DEAN W | 2010 | ACS Nano2010，4，4： | 1 |
| 18 | Novel application of four- dimensional sonography with B-flow imaging and spatiotemporal image correlation in the assessment of fetal congenital heart de- fects显示文摘 | Hongmei W Ying Z Ailu C | 2012 | Echocardiography2012，29，5： | 1 |
| 19 | The p300/CBP associated fac-tor: is frequently downregulated in intestinal-type gastric carcinoma andconstitutes a biomarker for clinical outcome显示文摘 | Ying M ZtWang J J Li D W | 2010 | Cancer Biol Ther2010，9，4： | 1 |
| 20 | Preparation, structure, and electrochemical properties of reduced graphene sheet films显示文摘 | Longhua T Ying W | 2009 | Advanced Functional Materials2009，19，17： | 1 |
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